Alan R. Brash

1949 -

country of citizenship: United States of America

educated at: University of Edinburgh, Strathallan School, Downing College, University of Cambridge

occupation: pharmacologist, researcher, professor

award received: Fellow of the American Association for the Advancement of Science

official website: medschool.mc.vanderbilt.edu/facultydata

Alan Richard Brash (born 1949) is a professor of pharmacology at Vanderbilt University. He is a leading authority on the biosynthesis of prostoglandins and eicosanoids. Source: Wikipedia (en)

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Articles 225

Date

Title

Authors

2021

Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions

Alan R. Brash
2021

Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes

Alan R. Brash
2020-02-01

SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

Tetsuya Hirabayashi, Yusuke Okuno, Hiroyuki Takama, Alan R. Brash
2020-10-01

Challenging the evidence for hepoxilin A3 being a mediator of neutrophil epithelial transmigration

Alan R. Brash
2020-12-17

Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function

Matthew L Edin, Alan R. Brash
2019-05-06

Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxyeicosadienoic acid

Valerie O'Donnell, Robert C Murphy, Varinder Aggarwal, Alan R. Brash
2018-11-10

Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function

Alan R. Brash
2018-02-19

Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function.

Alan R. Brash
2017-06-19

Oxidation of C18 Hydroxy-Polyunsaturated Fatty Acids to Epoxide or Ketone by Catalase-Related Hemoproteins Activated with Iodosylbenzene

Tarvi Teder, Alan R. Brash
2017-03-29

A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity

Tarvi Teder, Alan R. Brash, Claus Schneider
2017-03-01

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

Tetsuya Hirabayashi, Hiroyuki Takama, Alan R. Brash
2016-05-03

The discovery and early structural studies of arachidonic acid

Robert C. Murphy, Alan R. Brash
2016-05-05

The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE.

Christopher P. Thomas, Valerie O'Donnell, Alan R. Brash
2016-09-22

The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides

Alan R. Brash
2015-06-22

A Catalase-related Hemoprotein in Coral Is Specialized for Synthesis of Short-chain Aldehydes: DISCOVERY OF P450-TYPE HYDROPEROXIDE LYASE ACTIVITY IN A CATALASE

Tarvi Teder, Helike Lõhelaid, Alan R. Brash
2015-07-21

Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase: Comparison with COX-1 and COX-2.

Alan R. Brash
2014-07-30

Inhibitory effects of a novel Val to Thr mutation on the distal heme of human catalase

Alan R. Brash
2014-03

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier

Christopher P. Thomas, Alan R. Brash
2014-09-17

Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.

Alan R. Brash
2014-03-21

An ancient relative of cyclooxygenase in cyanobacteria is a linoleate 10S-dioxygenase that works in tandem with a catalase-related protein with specific 10S-hydroperoxide lyase activity

Alan R. Brash
2014-10-07

Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction

Tarvi Teder, Alan R. Brash
2013-01-23

Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis

Christopher P. Thomas, Valerie O'Donnell, Alan R. Brash
2013-05-23

Demonstration of HNE-related aldehyde formation via lipoxygenase-catalyzed synthesis of a bis-allylic dihydroperoxide intermediate

Alan R. Brash
2013-05-24

Isolation and characterization of two geometric allene oxide isomers synthesized from 9S-hydroperoxylinoleic acid by cytochrome P450 CYP74C3: stereochemical assignment of natural fatty acid allene oxides

Alan R. Brash, Claus Schneider
2012-05-24

Cytochrome P450-type hydroxylation and epoxidation in a tyrosine-liganded hemoprotein, catalase-related allene oxide synthase

Alan R. Brash
2012-12-13

Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration

Alan R. Brash
2011-09-22

Coordination modes of tyrosinate-ligated catalase-type heme enzymes: magnetic circular dichroism studies of Plexaura homomalla allene oxide synthase, Mycobacterium avium ssp. paratuberculosis protein-2744c, and bovine liver catalase in their ferric and ferrous states

John H. Dawson, Alan R. Brash
2011-07-08

Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope

Alan R. Brash
2011-01-14

The structure of human 5-lipoxygenase

Alan R. Brash
2011-01-01

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition

Alan R. Brash, Claus Schneider
2011-12-10

8R-Lipoxygenase-catalyzed synthesis of a prominent cis-epoxyalcohol from dihomo-γ-linolenic acid: a distinctive transformation compared with S-lipoxygenases

Alan R. Brash
2011-10-05

Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistry

Alan R. Brash, Claus Schneider

Human - wd:Q21934160

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