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mTOR is a key modulator of ageing and age-related disease

author

Matt Kaeberlein

1971 -

published in: Nature

date of publication: 2013-01-17

language: English

main subject: MTOR, aging-associated disease, human ageing

Cites articles 100

Date

Title

Authors

2012-05-04

Short-term calorie restriction enhances skeletal muscle stem cell function

Lydia Finley, Marcia C. Haigis
2012-04-13

mTOR signaling in growth control and disease

David M. Sabatini
2012-03-01

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

Dudley W Lamming, Pekka Katajisto, Marcus D Goncalves, David M. Sabatini, Joseph A. Baur
2012-05-01

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, David M. Sabatini
2012-08-29

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
2012-07-01

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival

Dao-Fu Dai, Peter S. Rabinovitch, Brian K Kennedy
2012-08-01

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

Court Hull, Mustafa Sahin
2012-06-28

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
2012-06-01

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Pekka Katajisto, Dudley W Lamming, David M. Sabatini, Ömer H Yilmaz, Mari Mino-Kenudson, Kıvanç Birsoy
2012-06-12

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

Michael J Steinbaugh, Andrzej Bartke, Richard A Miller
2012-06-04

Rapamycin slows aging in mice

Susan Brooks, Maria Woodward
2012-05-02

A unifying model for mTORC1-mediated regulation of mRNA translation

Timothy C Wang, David M. Sabatini, Nathanael Gray
2012-08-01

Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy
2012-04-11

Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications
2012-01-05

Timing of onset of cognitive decline: results from Whitehall II prospective cohort study

Archana Singh-Manoux, Mika Kivimäki, Claudine Berr, Klaus P. Ebmeier, Aline Dugravot, Jane E. Ferrie, M. Maria Glymour
2012-02-01

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

Arlan G. Richardson
2012-08-01

Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
2012-07-23

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice

Bart Everts
2012-01-01

Rapamycin-induced enhancement of vaccine efficacy in mice
2012-06-27

Ageing: A healthy diet for stem cells.

Matt Kaeberlein
2012-06-07

Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats

Nataliya Kolosova, Natalia Muraleva, Mikhail Blagosklonny
2012-10-04

Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice.
2012-08-23

Preventive and therapeutic effects of rapamycin, a mammalian target of rapamycin inhibitor, on food allergy in mice
2011-02

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Joseph A. Baur, David Sinclair, Rafael de Cabo, Richard A Miller
2011-10-31

Rapamycin passes the torch: a new generation of mTOR inhibitors
2011-11-01

Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis

Roberto Rosales-Reyes, Benjamin T Kopp, Miguel A. Valvano
2011-09-28

Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

Arlan G. Richardson
2011-12-01

mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases

Elena Ortona
2011-07-14

Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish

Margaret M Redfield, Stephen C Ekker
2011-07-01

Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans

Gawain McColl, Gordon J. Lithgow
2011-06-01

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells

Francis Collins
2011-06-01

Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling

Article - wd:Q24610741

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