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A unifying model for mTORC1-mediated regulation of mRNA translation.

author

Timothy C Wang

David M. Sabatini

1968 -

Nathanael Gray

2000 -

published in: Nature

date of publication: 2012-05-02

language: English

Cites articles 39

Date

Title

Authors

2011-01-01

Cap-assisted internal initiation of translation of histone H4

Franck Martin, Gilbert Eriani
2010-12-15

mTOR: from growth signal integration to cancer, diabetes and ageing

Alejo Efeyan, David M. Sabatini
2010-12-01

Aligning short sequencing reads with Bowtie
2010-10-14

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

Nathanael Gray, David M. Sabatini
2010-08-12

Mammalian microRNAs predominantly act to decrease target mRNA levels

Jonathan Weissman, David P. Bartel
2010-05-01

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

Nahum Sonenberg, George Thomas, Ola Larsson, Ivan Topisirovic
2009-11-01

Epithelial-mesenchymal transitions in development and disease

Hervé Acloque, M. Angela Nieto
2009-11-16

IRESite--a tool for the examination of viral and cellular internal ribosome entry sites

Martin Mokrejs, Tomas Masek, Václav Vopálenský, Martin Pospisek
2009-11-12

DBTSS provides a tissue specific dynamic view of Transcription Start Sites

Sumio Sugano, Yutaka Suzuki, Riu Yamashita, Hiroyuki Wakaguri, Kenta Nakai
2009-04-10

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

Jonathan Weissman
2009-02-10

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Robbie Loewith, Zachary A Knight
2009-03-20

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
2009

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Richard A. Lempicki
2009-01

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Richard A. Lempicki
2008-12-01

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner
2008-10-27

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
2008-05-30

Mapping and quantifying mammalian transcriptomes by RNA-Seq

Barbara J. Wold
2008-04-21

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy
2008-07-24

All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAs

Valentina Iadevaia
2007-07-23

Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
2007-06-11

Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner

David Stokoe
2006-09-06

p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins
2006-03-24

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

Eric Lander, William C Hahn, David E Root, David M. Sabatini
2006-03-16

mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin

Jeffrey Shabanowitz
2005

A second look at cellular mRNA sequences said to function as internal ribosome entry sites
2005-07-01

DINAMelt web server for nucleic acid melting prediction
2005-04-04

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site

David M. Sabatini
2005-01-04

Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.
2004-08-15

Upstream and downstream of mTOR

Nahum Sonenberg
2004-04-01

eIF-4E expression and its role in malignancies and metastases

Arrigo De Benedetti
2004-04

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

Virginie Mieulet, George Thomas
2003-10-23

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

Article - wd:Q35945036

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