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mTOR: from growth signal integration to cancer, diabetes and ageing

auteur·ice

Alejo Efeyan

David M. Sabatini

1968 -

publié dans: Nature Reviews Molecular Cell Biology

date de publication: 2010-12-15

langue: anglais

sujet principal: biologie cellulaire

Articles cités 200

Trop d'entités demandées (207). Seules 200 entitées sont affichées.

Date

Titre

Auteur·ices

2010-04-01

Extending healthy life span--from yeast to humans

Linda Partridge, Luigi Fontana, Valter Longo
2010-04-16

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Roberto Zoncu, David M. Sabatini
2010-06-06

Termination of autophagy and reformation of lysosomes regulated by mTOR

Viola Oorschot, Judith Klumperman, Christina K McPhee
2010-06-01

Structure of the human mTOR complex I and its implications for rapamycin inhibition

David M. Sabatini
2010-05-01

A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration
2010-03-01

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
2010-01-01

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

Linda Partridge, Ivana Bjedov, Fiona Kerr, Janne M. Toivonen, Cathy Slack
2010-01-13

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

Marina Konopleva
2010-03-01

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR

Darren J. Burgess, Greg M. Findlay
2010-05-01

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

Nahum Sonenberg, George Thomas, Ola Larsson, Ivan Topisirovic
2010-07-01

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
2010-08-04

Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor

Patrick Frost, Joseph Gera
2009-12-02

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

Linda Partridge, Richard C Grandison, Matthew D Piper
2009-08

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
2009-10

Atg101, a novel mammalian autophagy protein interacting with Atg13

Noboru Mizushima
2009-07-16

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Richard A Miller
2009-05-14

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

David M. Sabatini, Nathanael Gray
2009-04

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

Mondira Kundu, Do-Hyung Kim
2009-04

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

Noboru Mizushima
2009-02-10

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Robbie Loewith, Zachary Knight
2009-02-01

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

Mark Magnuson, David M. Sabatini
2009-09-11

The Vam6 GEF controls TORC1 by activating the EGO complex

Claudio De Virgilio, Robbie Loewith
2009-01-14

TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain
2009-04

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

James Rochon, James Bain, Cris A Slentz, Christopher B Newgard, William Yancy, Olga R Ilkayeva, Brett R Wenner, Michael Muehlbauer, Lillian F Lien, Andrea Haqq, Svati H Shah, Michelle Arlotto, Dianne Gallup, Laura Svetkey
2009

Regulation mechanisms and signaling pathways of autophagy
2009-04-01

Autophagy regulates lipid metabolism

Ana María Cuervo, Masaaki Komatsu
2009-10-02

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

Janet Thornton, Klaus Okkenhaug
2009-05

Molecular mechanisms of mTOR-mediated translational control
2009-03-20

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
2009-12-10

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
2009-11-27

mTOR and cancer: many loops in one pathway

Alejo Efeyan, David M. Sabatini
2009-11-24

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

Article - wd:Q24633662

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