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Polyglutamine neurodegeneration: expanded glutamines enhance native functions

লেখক

Harry T. Orr

1949 -

এতে প্রকাশিত: Current Opinion in Genetics & Development

তারিখে প্রকাশিত: 2012-06

ভাষা: ইংরেজি ভাষা

Cites articles 35

তারিখ

শিরোনাম

লেখকগণ

2011-11

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

Géraldine Liot, Fabrice P Cordelières, José R Pineda, Nathalie Spassky, Robert J Ferrante
2011-11-01

Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua

Chad Shaw, Harry T. Orr, Huda Zoghbi
2011-08-11

14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus

Shaojuan Lai, Harry T. Orr, Huda Zoghbi
2011-01-18

Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration

ক্রিস্টোফার এস ওয়ার্ড, Harry T. Orr, Huda Zoghbi
2010-12-01

A tissue-specific atlas of mouse protein phosphorylation and expression

Edward L Huttlin, Judit Villén, Steven P. Gygi, Sean A Beausoleil, Mark P Jedrychowski
2010-10-04

Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment

Douglas R Langbehn, Peggy C Nopoulos, Hans Johnson, Vincent A. Magnotta, Jane S. Paulsen, রজার এ বার্কার, Christopher A Ross, Ronald K Pierson, Leigh J Beglinger, PREDICT-HD Investigators and Coordinators of the Huntington Study Group
2010-09-01

Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
2010-09-01

SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.

Harry T. Orr, Huda Zoghbi, J. Michael Andresen
2010-09-01

PolyQ disease: too many Qs, too much function?
2010-07-01

Molecular mechanisms and potential therapeutical targets in Huntington's disease

Elena Cattaneo, Chiara Zuccato, Marta Valenza
2009-09-09

Secondary Structure of Huntingtin Amino-Terminal Region

Zbyszek Otwinowski
2009-12-23

Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors

Toby J. Gibson, Annalisa Pastore, Molly Strom
2008-02

Cerebellar development and disease

Kathleen J Millen
2008-04-10

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

Aaron B. Bowman, Harry T. Orr, Huda Zoghbi
2007-01-01

Trinucleotide repeat disorders

Huda Zoghbi, Harry T. Orr
2006-11-17

RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

Harry T. Orr, Huda Zoghbi, J. Michael Andresen
2006-01

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

Alexis Brice, Thierry Frébourg, Dominique Campion, Didier Hannequin, Annie Laquerrière
2006-12-01

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.

Aaron B. Bowman, Huda Zoghbi, Harry T. Orr
2005-10-01

Diseases of unstable repeat expansion: mechanisms and common principles

Jennifer R Gatchel, Huda Zoghbi
2004-01-30

The structure of the AXH domain of spinocerebellar ataxin-1

Dmitry B Veprintsev
2003-10-31

alpha-Synuclein locus triplication causes Parkinson's disease

Katrina Gwinn, Matthew J. Farrer, John Anthony Hardy, Andrew Singleton
2003-08

The hunt for huntingtin function: interaction partners tell many different stories
2003-05-01

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

Summer F. Acevedo, Harry T. Orr, Huda Zoghbi
2003-05-01

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

Harry T. Orr, Huda Zoghbi
2002-03-15

Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus

Nathaniel Heintz
2002-08-01

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

Hiromu Tanimoto
2002-08-01

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

Hiroaki Adachi, Gen Sobue
2002-09-01

Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women
1998-10-01

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

Pamela J. Skinner, Huda Zoghbi, Harry T. Orr
1997-12

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin
1995-11-23

A huntingtin-associated protein enriched in brain with implications for pathology

Solomon Halbert Snyder
1993-03

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Michael C O'Donovan

নিবন্ধ - wd:Q27026773

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