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PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model

published in: PLOS One

date of publication: 2012

language: English

main subject: breast carcinoma

Cites articles 48

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2011-05

Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase

Israel Vlodavsky
2011

Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
2011

M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis
2011-08-07

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

Toni Celià-Terrassa, Guohong Hu, Toni Ibrahim, Hani Goodarzi, Laura Mercatali, Francesca M. Buffa, Adrian Harris, Yibin Kang
2011-05-31

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

Katrien De Bock, Massimiliano Mazzone, Peter Carmeliet
2011-05-31

Mutual enhancement between heparanase and vascular endothelial growth factor: a novel mechanism for melanoma progression
2011-04-19

Rethinking the metastatic cascade as a therapeutic target
2011-03-01

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis

John M Ebos
2011-04-20

Preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin
2011-02-01

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

Maree Smith
2011-01-25

MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase
2011-01-21

SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis
2011-01-06

In the end what matters most? A review of clinical endpoints in advanced breast cancer

John R. Mackey
2010-10-23

Heparin/heparan sulphate-based drugs
2010-08-31

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis
2010-01-01

Chemical Tumor Biology of Heparan Sulfate Proteoglycans
2010-05-01

Guidelines for the welfare and use of animals in cancer research

Eric O Aboagye, Ian J Stratford
2010-03-20

Cancer metastasis as a therapeutic target

Jonathan P. Sleeman, Patricia Steeg
2010-02-09

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
2009-03-03

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

Oriol Casanovas, Gabriele Bergers
2009-03-03

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
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An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis

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2009-08-11

Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy

John M Ebos
2009-06-22

Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in heparanase over-expressing CHO-K1 cells
2009-05-24

An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse

Bob van de Water
2009-04-09

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy
2009-02-15

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage

Chun-Jen Liu, Ming-Chih Ho, Rey-heng Hu, Chen Pei-jer
2008-06-01

Metastatic breast cancer: the treatment challenge
2008-04-01

Assessing the measure of a new drug: is survival the only thing that matters?

Daniel J. Sargent
2007-10-05

Heparanase induces Akt phosphorylation via a lipid raft receptor

Israel Vlodavsky
2007-06-01

Heparanase expression in circulating lymphocytes of breast cancer patients depends on the presence of the primary tumor and/or systemic metastasis
2007-03-05

Heparanase: a target for drug discovery in cancer and inflammation

Article - wd:Q27327191

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