L. Mario Amzel

1942 - 2021

award received: Fellow of the American Association for the Advancement of Science

León Mario Amzel (1942–2021) was an Argentine chemist, biophysicist, professor and former director of the Department of Biophysics and Biophysical Chemistry at the Johns Hopkins School of Medicine. He was known for his work in biophysics; structural biology; and assisting with the development of the first high-resolution images of how antibody-antigen recognition occurs. Source: Wikipedia (en)

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Articles 154

Date

Title

Authors

2018

Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase

Sandra B. Gabelli, Elizabeth A. Eipper, Richard Mains, L. Mario Amzel, Katarzyna Rudzka, Ninian J Blackburn, Sweta Maheshwari
2017-07-04

Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition.

L. Mario Amzel, Sandra B. Gabelli, Michelle S Miller, Sweta Maheshwari
2016-03-03

Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights

L. Mario Amzel, Mauricio Urquiza, Mario A Bianchet
2016-09-28

Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis

Sandra B. Gabelli, J Alfonso Leyva, L. Mario Amzel, Lin-Woo Kang, Suzanne F O'Handley
2016-08-25

Na+ coordination at the Na2 site of the Na+/I- symporter

L. Mario Amzel
2015-07-28

Calmodulin and Ca(2+) control of voltage gated Na(+) channels

Sandra B. Gabelli, L. Mario Amzel, Jesse Yoder, Gordon F Tomaselli
2015-06-01

Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters

L. Mario Amzel
2015-01-07

Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cations

L. Mario Amzel, Man-Kyo Chung
2015-04-17

A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development

L. Mario Amzel, Thanh H Pham, Andres H de la Peña, Sandra B. Gabelli
2015-11-02

Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus

L. Mario Amzel, Andres H de la Peña, Krisna C Duong-Ly, Sandra B. Gabelli, Andrew J Schoeffield
2015-06-30

Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.

L. Mario Amzel, Sandra B. Gabelli
2015-07-23

Sodium/Iodide Symporter Mutant V270E Causes Stunted Growth but No Cognitive Deficiency

L. Mario Amzel
2014-03-01

Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects

L. Mario Amzel, Krisna C Duong-Ly, Daniele Chaves-Moreira, Sandra B. Gabelli, Bert Vogelstein
2014-06-03

Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter

L. Mario Amzel
2014-03

Structural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonates

L. Mario Amzel, Sandra B. Gabelli, Dolores Gonzalez-Pacanowska, Marcel Kaiser, Eric Oldfield, Srinivas Aripirala
2014-07-01

Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Bert Vogelstein, Michelle S Miller, Kenneth W Kinzler, Philip E. Thompson, L. Mario Amzel, Sandra B. Gabelli, Oleg Schmidt-Kittler
2014-11-05

Regulation of the NaV1.5 cytoplasmic domain by calmodulin

L. Mario Amzel, Victoria Halperin Kuhns, Sandra B. Gabelli, Mario A Bianchet, Agedi N Boto, Jean Jakoncic, Srinivas Aripirala, Jesse Yoder, Gordon F Tomaselli
2013-03-06

Structural and thermodynamic insights into the recognition of native proteins by anti-peptide antibodies

L. Mario Amzel
2013-02

Coordination of peroxide to the CuM center of peptidylglycine α-hydroxylating monooxygenase (PHM): structural and computational study

L. Mario Amzel, Diego M Moreno, Darío A. Estrin, Elizabeth A. Eipper, Richard Mains, Katarzyna Rudzka
2013-05-01

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

L. Mario Amzel, Sandra B. Gabelli, Shridhar Bhat, Xiaochun Chen
2013-05-23

Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

L. Mario Amzel, Sandra B. Gabelli, Joong Sup Shim, Michelle S Miller, Shridhar Bhat, Xiaochun Chen, Phillip O. Crews
2013

A UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan Biosynthesis

L. Mario Amzel, Krisna C Duong-Ly, Sandra B. Gabelli, Maurice J Bessman
2013-07-09

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

L. Mario Amzel, Sandra B. Gabelli, Becky Tu-Sekine, Daniel Raben
2013-05-06

Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS).

L. Mario Amzel
2012-08-30

Estimation of free-energy differences from computed work distributions: an application of Jarzynski's equality.

L. Mario Amzel, Ignacia Echeverria
2012-12-05

Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2

L. Mario Amzel, Gyanu Lamichhane, Mario A Bianchet, William Bishai
2012-07-26

Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

L. Mario Amzel, Roberto Docampo, Sergio Hernán Szajnman, Sandra B. Gabelli, Juan B. Rodríguez, Jean Jakoncic, Srinivas Aripirala
2011-02-01

Direct activation of Epac by sulfonylurea is isoform selective

L. Mario Amzel
2011-08

Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition

L. Mario Amzel, Sandra B. Gabelli, Maurice J Bessman, Agedi N Boto, Jean Jakoncic
2011-04-13

The Hypoxic Regulator of Sterol Synthesis Nro1 Is a Nuclear Import Adaptor

L. Mario Amzel, Mario A Bianchet
2011-07

The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities

L. Mario Amzel, Krisna C Duong-Ly, Sandra B. Gabelli, Andrew J Schoeffield, Maurice J Bessman
2011-10-19

Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)

L. Mario Amzel, Orsolya Dohan, Antonia Follenzi

Human - wd:Q28031687

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