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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

author

Stephen Pasternak

published in: Journal of Biological Chemistry

date of publication: 2003-07-18

language: English

main subject: cell biology, biochemistry

Cites articles 81

Date

Title

Authors

2003-01-01

Nicastrin is a resident lysosomal membrane protein
2002-04-01

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Peter Henry St George-Hyslop
2002-07-01

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

Javier Apfeld
2002-08-26

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

Stefan Prokop, Christian Haass, Dieter Edbauer
2002-11-22

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
2002-07-15

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

Peter Henry St George-Hyslop
2002-05-24

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin
2002-07-29

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

Christian Haass, Dieter Edbauer, Anja Capell
2002-05-24

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

Paul Mathews, Peter Henry St George-Hyslop
2002-01-01

Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules

Niels Borregaard
2002-04-01

Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles
2002-05-01

Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation

Jens Wiltfang, Johannes Kornhuber
2002-12-01

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

Peter Henry St George-Hyslop
2002-11-18

Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells

Jyoti K. Jaiswal, Sanford M Simon, Norma Andrews
2002-03-23

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells
2002-11-01

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

Paul Greengard, Gunnar K. Gouras, M. Flint Beal, Reisuke H Takahashi
2002-03-01

Cerebellar diffuse amyloid plaques are derived from dendritic Abeta42 accumulations in Purkinje cells
2001-07-01

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease

Vincenzo Carbone, R.M. Damian Holsinger, Marijke Sernee
2001-06-14

Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage
2001-08-13

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein
2001-04-01

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides
2001-03-01

Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide
2001-07-27

Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes
2001-07-03

Cellular membrane composition defines A beta-lipid interactions
2001-03-01

Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption
2001-11-01

Organelle-specific initiation of cell death pathways

Guido Kroemer
2001-02-01

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
2000-07-01

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
2000-11-01

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

Peter Henry St George-Hyslop, Ekaterina Rogaeva, Toshitaka Kawarai
2000-02-18

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

Joseph L. Goldstein
2000-09-01

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.
2000-10-01

Proteomics of rat liver Golgi complex: minor proteins are identified through sequential fractionation

Article - wd:Q28568133

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