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Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice

author

James Murphy

Carolyn A de Graaf

Nicos A. Nicola

Benjamin T. Kile

Donald Metcalf

Maria Kauppi

Doug Hilton

Craig D Hyland

Adrienne A Hilton

Kylie T. Greig

published in: Blood

date of publication: 2008-08-06

language: English

main subject: Myeloblastosis oncogene, E1A binding protein p300, Myeloproliferative leukemia virus oncogene, thrombocytopenia

Cites articles 15

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Title

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2005-02-01

c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
2005-01-21

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.

Nicos A. Nicola, Marina R. Carpinelli, Doug Hilton, Donald Metcalf, Craig D Hyland, Sandra L Mifsud
2004-04-07

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

Marina R. Carpinelli, Andrew W. Roberts, Nicos A. Nicola, Robert G. Ramsay, Doug Hilton, Donald Metcalf, Ladina Di Rago, Tracy A Willson, Craig D Hyland, Adrienne A Hilton, Jennifer L Antonchuk, Sandra L Mifsud
2002-10-01

A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis

Fayçal Boussouar, Paul Brindle, Jan M van Deursen
2001-06-29

FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties

Tom Blundell
2001-08-01

Thrombocytopenic c-mpl(-/-) mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response
1999-08-01

Role of secondary structure in discrimination between constitutive and inducible activators
1998-05-01

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
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Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation

Lewis C. Cantley
1997-12-01

Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions

H. Jane Dyson, Peter Wright
1996-03-01

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
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Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
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Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity
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Thrombocytopenia in c-mpl-deficient mice
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A genetic map of the mouse suitable for typing intraspecific crosses

Article - wd:Q28593767

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