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Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

published in: Acta Neuropathologica

date of publication: 2016-12-08

main subject: Alzheimer's disease, risk factor

Cites articles 27

Date

Title

Authors

2016-06-02

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Jean-Charles Lambert, Kris Gevaert, Jean-Jacques Hauw, Marie Lesaffre, Florent Letronne, Linda Chami, Pierre Dourlen, David Hot, Marc Dhenain, David Tulasne, Benoit Deprez, Frédéric Checler, Philippe Amouyel, Anne-Sophie Hérard, Florence Pasquier, Charlotte Delay, Fanny Eysert, Amandine Flaig, Florie Demiautte, Nicolas Malmanche, Yoann Sottejeau, Elisabeth Werkmeister, Anne-Marie Ayral, Florence Leroux, Julien Chapuis
2016-05-24

miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's disease

Jean-Charles Lambert, Julie Dumont, Philippe Amouyel, Charlotte Delay, Benjamin Grenier-Boley
2016-04-26

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology

Jean-Charles Lambert, Pierre Dourlen, Francisco J Fernandez-Gomez, Céline Bellenguez, Marie-Christine Galas, Philippe Amouyel, Nicolas Sergeant, Luc Buée, Benjamin Grenier-Boley
2016-01-27

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

Emanuel Rognoni, Reinhard Fässler
2015-11-09

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

Zhentao Zhang, Jianping Jia
2015-08-31

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Helene Marie, Marc Aurel Busche, Lewis D B Evans, Steven Moore, Dietmar R. Thal, Felix Meissner, Jochen Herms, Lars Lannfelt, Vilmantas Giedraitis
2015-07-23

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

Stefan F Lichtenthaler, Frédéric Checler
2015-02-27

Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing

Xiaohua Douglas Zhang, Paolo Uva, William J. Ray, Kenji Mizuguchi
2014-09-18

Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit
2013-12

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert, Carla Ibrahim-Verbaas, Denise Harold, Céline Bellenguez, Joshua C Bis, Vincent Chouraki, Chiao-Feng Lin, M. Arfan Ikram, Agustín Ruíz, Florence Pasquier, Najaf Amin, Claudine Berr, Vincent Deramecourt, Simon Lovestone, Luc Letenneur, M. Ilyas Kamboh, Stephen Todd, Peter Henry St George-Hyslop, Antony Bayer, Debby W Tsuang, Magda N. Tsolaki, Paola Bossù, Sandro Sorbi, Florentino Sanchez-Garcia, Nick C. Fox, Carol Brayne, Fiona E. Matthews, Patrizia Mecocci, Francesco Panza, Paolo Caffarra, Benedetta Nacmias, Cristina Razquin, Pau Pastor, Michael C O'Donovan, Clive Holmes, Alexis Brice, Karen Ritchie, Kathryn L. Lunetta, Christophe Tzourio, Markus M Nöthen, Caroline Graff, Peter Holmans, Lindsay A. Farrer, Sudha Seshadri, Philippe Amouyel, Albert Hofman, Jerome I Rotter, Albert V. Smith, Carlos Cruchaga, Ian W. Craig, Alison Goate, Anthony R Green, Richard H Myers, Jordi Clarimón, Janet T. Powell, Bruce M. Psaty, Christine Van Broeckhoven, John Anthony Hardy, Werner Maier, Richard Mayeux, Mark Lathrop, Cornelia M. van Duijn, Benjamin Grenier-Boley, Kara L Hamilton-Nelson, European Alzheimer's Disease Initiative (EADI), Pascale Barberger-Gateau, Lorna M. Lopez, Amanda J Bennett, Maria Candida Deniz Naranjo, Peter B. Jones, Alan J. Thomas, Jean-François Dartigues
2013-09-25

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

Norbert Perrimon, Mel B. Feany, Nicholas H Brown, Philip L De Jager
2013-01-01

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system
2013-07-29

Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism

Katarzyna Białkowska, Elzbieta Pluskota, Dorota Szpak
2013-05-14

Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance
2013-04-04

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease

Margaret A. Pericak-Vance, Matthew Bailey, Celeste M Karch, Bruno A Benitez, Denise Harold, Carlos Cruchaga, Alison Goate, Lindsay A. Farrer, John Q. Trojanowski, David M. Holtzman, Sheng Chih Jin, Richard Mayeux, Alzheimer's Disease Neuroimaging Initiative, David A Bennett, John C. Morris, Anne M Fagan, Jonathan L Haines, Philip L De Jager, Leslie M. Shaw, John S. K. Kauwe, Joshua M Shulman, D Galasko, Oscar Harari, Yefei Cai, David S Carrell, Sarah Bertelsen, Lori B Chibnik, Vivianna M Van Deerlin, Elaine Peskind, Alzheimer Disease Genetic Consortium (ADGC), Gerard D Schellenberg, Amy Gerrish, Tara Skorupa, GERAD Consortium, Virginia Man-Yee Lee, Amanda T Jeng
2012-07-11

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Kári Stefánsson, Augustine Kong, Hreinn Stefansson, Unnur Þorsteinsdóttir, Aarno Palotie, Patrick Sulem, Tushar Bhangale, Gyda Bjornsdottir, Daníel F. Guðbjartsson, Erik G Jönsson, Ole A. Andreassen, Stacy Steinberg, Jon Snaedal, Johanna Huttenlocher, Thorlakur Jonsson
2012-02-01

Physiological functions of APP family proteins
2011-08-08

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

Sebastian Munck, Giampietro Schiavo, Bart De Strooper
2011-03-01

Genetics of Alzheimer's disease: new evidences for an old hypothesis?

Jean-Charles Lambert, Philippe Amouyel
2011-02-28

Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein

Philippe Marambaud, Valérie Vingtdeux, Fabien Campagne, Peter Davies, Julien Chapuis
2009-12-01

Integrins: masters and slaves of endocytic transport

Patrick T Caswell, Jim C Norman
2009-03-22

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

Jim C Norman, Jonathan C Welti, Stephen Douglas Robinson, Vassiliki Kostourou, Kairbaan Hodivala-Dilke
2008-11-27

Abnormal cleavage of APP impairs its functions in cell adhesion and migration
2008-06-23

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

Dennis J. Selkoe, Tracy L Young-Pearse
2006-03-01

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

William E. Klunk, David M. Holtzman, Anne M Fagan, Steven T. DeKosky, John C. Morris, Mark A. Mintun, Robert H Mach, Michael A Spinner
2000-08-01

Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.

David M. Holtzman, Anne M Fagan, John C. Morris
1995-10-01

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

Article - wd:Q33665842

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