Frédéric Checler

1957 -

educated at: Délégation Provence et Corse

occupation: researcher

award received: Prize Jaffé

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Articles 179

Date

Title

Authors

2021-01-04

Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

Mikael Marttinen, Philippe Amouyel, Jean-Charles Lambert, Julien Chapuis, Sébastien S. Hébert, Benjamin Grenier-Boley, Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anaїs-Camille Vreulx, Amandine Flaig, Xavier Hanoulle, Florie Demiautte, Mari Takalo, Shruti Desai, Ian Pike, Frédéric Checler, Mélissa Farinelli, Charlotte Delay, Nicolas Malmanche, Devrim Kilinc
2020-11-03

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

Mikael Marttinen, Philippe Amouyel, Jean-Charles Lambert, Julien Chapuis, Sébastien S. Hébert, Benjamin Grenier-Boley, Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anaїs-Camille Vreulx, Amandine Flaig, Xavier Hanoulle, Florie Demiautte, Mari Takalo, Shruti Desai, Ian Pike, Frédéric Checler, Mélissa Farinelli, Charlotte Delay, Nicolas Malmanche, Devrim Kilinc
2020-11-17

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology

Cristine Alves da Costa, Frédéric Checler
2020-12-01

Alterations of the Endoplasmic Reticulum (ER) Calcium Signaling Molecular Components in Alzheimer's Disease

Mounia Chami, Frédéric Checler
2020-08-28

Pyk2 overexpression in postsynaptic neurons blocks amyloid β<sub>1-42</sub>-induced synaptotoxicity in microfluidic co-cultures

Devrim Kilinc, Frédéric Checler, Jean-Charles Lambert
2019-02-21

The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again

Paul Hofman, Pascal Barbry, Frédéric Checler, Gael Cristofari, Marius Ilié, Bernard Mari, Charles Marquette, Pierre Saintigny, Ellen Van Obberghen-Schilling
2019-01-01

Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?

Frédéric Checler
2018-01-19

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.

Eric Duplan, Frédéric Checler, Cristine Alves da Costa
2018-08-24

Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease?

Frédéric Checler
2018-10-17

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking

Frédéric Checler
2018-10-19

Chronic fornix deep brain stimulation in a transgenic Alzheimer's rat model reduces amyloid burden, inflammation, and neuronal loss

Lydia Kerkerian-Le Goff, Frédéric Checler
2018-05-11

Nuclear TP53: An unraveled function as transcriptional repressor of PINK1

Frédéric Checler, Cristine Alves da Costa
2018-01-01

The Transcription Factor Function of Parkin: Breaking the Dogma

Cristine Alves da Costa, Frédéric Checler
2018-07-12

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice

Frédéric Checler, Raphaëlle Pardossi-Piquard
2018-08-29

Neurolysin: From Initial Detection to Latest Advances

Frédéric Checler, Emer S Ferro
2017-09-15

Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases.

Frédéric Checler, Cristine Alves da Costa
2017-05-05

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor

Renaud Bussiere, Alain Lacampagne, Frédéric Checler, Mounia Chami, Steven R. Reiken
2017-01-20

The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities

Frédéric Checler
2017-01-01

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

Bénédicte Oulès, Renaud Bussiere, Mariusz R Wieckowski, Frédéric Checler, Mounia Chami
2017-06-19

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits

Frédéric Checler, Fabrice Duprat, Albano C Meli, Mounia Chami, Nathalie Saint, Alain Lacampagne, Ottavio Arancio, Steven R. Reiken
2017-05-03

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

Frédéric Checler, Eric Duplan, Mounia Chami, Nicolas Sergeant, Cristine Alves da Costa, Vuk Stambolic
2017-01-04

The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease

Frédéric Checler
2016-12-30

α-synuclein and p53 functional interplay in physiopathological contexts.

Cristine Alves da Costa, Frédéric Checler
2016-04-04

Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice

Frédéric Checler
2016-04-08

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

Frédéric Checler
2016-02-02

Direct α-synuclein promoter transactivation by the tumor suppressor p53.

Eric Duplan, Frédéric Checler, Cristine Alves da Costa
2016-04-30

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

Frédéric Checler, William L. Klein
2016-06-02

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Jean-Charles Lambert, Kris Gevaert, Jean-Jacques Hauw, Marie Lesaffre, Florent Letronne, Linda Chami, Pierre Dourlen, David Hot, Marc Dhenain, David Tulasne, Benoit Deprez, Frédéric Checler, Philippe Amouyel, Anne-Sophie Hérard, Florence Pasquier, Charlotte Delay, Fanny Eysert, Amandine Flaig, Florie Demiautte, Nicolas Malmanche, Yoann Sottejeau, Elisabeth Werkmeister, Anne-Marie Ayral, Florence Leroux, Julien Chapuis
2016-09-20

The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model

Eric Duplan, Frédéric Checler
2016-11-17

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1.

Frédéric Checler
2015-11-17

Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells

Frédéric Checler, Weihong Song, Htut Htut Htoo, Hisashi Iizasa
2015-12-01

Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations

Eric Duplan, Frédéric Checler

Human - wd:Q38321085

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