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Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

著者

Paola Monti

Alessandra Bisio

Yari Ciribilli

Paola Menichini

Debora Russo

Michael A Resnick

Alberto Inga

Chiara Perfumo

Gilberto Fronza

この作品が含まれる作品: Molecular Cancer Research

出版日: 2011-02-22

Cites articles 36

Date

タイトル

著者

2009-08-10

Ultraslow oligomerization equilibria of p53 and its implications

Alan Fersht, Nina Morgner, キャロル・V・ロビンソン
2008-08-06

Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome

Uri Tabori, David Malkin, Stephen W. Scherer, Lars Feuk
2008-05-01

Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells

Lukas Vrba
2008-06-13

Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer

Nur Mohammad Monsur Hassan, Rahena Akhter
2007-07-18

p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells

董培新, 櫻木範明
2007-07-01

Transcriptional functionality of germ line p53 mutants influences cancer phenotype

Paola Monti, Yari Ciribilli, Paola Menichini, Lucio Luzzatto
2007-06

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

Pierre Hainaut, Ewy Mathé
2007-05-01

Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage

Tyler Jacks
2006-09

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

Ada Sacchi, Marcella Mottolese
2006-07-21

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

Hua Qian
2006-02-21

The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families

Maria Isabel Achatz, Ademar Lopes, Mauro Rossi, Edenir Inêz Palmero, Pierre Hainaut, Patricia Ashton-Prolla, Roberto Giugliani
2006-01-01

Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
2006-06-05

Germline TP53 R337H mutation is not sufficient to establish Li-Fraumeni or Li-Fraumeni-like syndrome.
2005-09-01

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development

Kenneth P Olive, David Tuveson, Tyler Jacks
2004-05-01

Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair

Paola Campomenosi
2003-08-08

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity
2003-06-25

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
2002-01-22

Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect
2002-12-01

Low rate of TP53 germline mutations in breast cancer/sarcoma families not fulfilling classical criteria for Li-Fraumeni syndrome

Gareth Evans
2002-05-31

Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent

Paola Monti, Yari Ciribilli, Paola Menichini
2002-03-01

Tumour p53 mutations exhibit promoter selective dominance over wild type p53.
2001-01-01

Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing
2001-06-01

p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements

Paola Campomenosi, Paola Monti, Michael A Resnick
2000-03-01

p53 mutations experimentally induced by 8-methoxypsoralen plus UVA (PUVA) differ from those found in human skin cancers in PUVA-treated patients
1999-10-01

Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme
1999-02-01

N-(2-chloroethyl)-N-nitrosourea tethered to lexitropsin induces minor groove lesions at the p53 cDNA that are more cytotoxic than mutagenic
1999-12-01

5-methylcytosine at HpaII sites in p53 is not hypermutable after UVC irradiation

Paola Monti, Paola Campomenosi, Paola Menichini
1999-06-01

Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent

Paola Monti
1998-08-01

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

Otto Hannes Vogel
1998-08-01

Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members.
1997-03-01

Determining mutational fingerprints at the human p53 locus with a yeast functional assay: a new tool for molecular epidemiology

Paola Monti, Francesco Molina
1997-10-01

Simple identification of dominant p53 mutants by a yeast functional assay

Sara Cresta, Paola Monti

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