Inventaire - dina vänner och gemenskaper är ditt bästa bibliotek

Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility

författare

Siew Lee Cheong

Stephanie Federico

Stefano Moro

Kenneth A. Jacobson

Zhan-Guo Gao

Silvia Paoletta

Giorgia Pastorin

Barbara Cacciari

Giampiero Spalluto

publicerad i: Journal of Medicinal Chemistry

utgivningsår: 2011-01-07

språk: engelska

Refererar artiklar 46

Datum

Titel

Författare

2010-02-25

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process

Stephanie Federico, Karl-Norbert Klotz, Stefano Moro, Kenneth A. Jacobson, Zhan-Guo Gao, Silvia Paoletta, Giorgia Pastorin, Barbara Cacciari, Giampiero Spalluto
2010-04-01

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relation

Karl-Norbert Klotz, Stefano Moro, Siew Lee Cheong, Stephanie Federico, Silvia Paoletta, Sonja Kachler, Barbara Cacciari, Giampiero Spalluto, Giorgia Pastorin, Anna V Dolzhenko, Anton V Dolzhenko
2009-01-01

Human A3 adenosine receptor as versatile G protein-coupled receptor example to validate the receptor homology modeling technology

Stephanie Federico, Stefano Moro
2009-12-01

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition

Stefano Moro, Silvia Paoletta
2009-01-01

Empirical scoring functions for advanced protein-ligand docking with PLANTS

Thomas Stützle
2008-11-21

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

Vadim Cherezov, Veli-Pekka Jaakola, Raymond C Stevens, Adriaan P IJzerman, Michael A Hanson, Ellen Y T Chien
2006-03-01

Progress in the pursuit of therapeutic adenosine receptor antagonists

Stefano Moro, Kenneth A. Jacobson, Zhan-Guo Gao, Giampiero Spalluto
2005-01-01

Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example

Stefano Moro, Kenneth A. Jacobson, Giampiero Spalluto
2005-11-01

Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists
2005-04-01

New adenosine A2A receptor antagonists: actions on Parkinson's disease models.

Annalisa Pinna
2005-03-01

Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists
2005-02-01

Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists
2004-03-25

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
2004-12-01

Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists
2004-10-01

Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists
2004-10-01

Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles
2003-11-01

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

Christa E Müller
2003-06-01

Adenosine receptors as targets for drug development
2003-09-01

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation

Stefano Moro
2002-12-01

Adenosine receptors in the nervous system: pathophysiological implications

Joaquim A. Ribeiro, Ana Sebastião, Alexandre de Mendonça
2002-08-01

Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist

Kenneth A. Jacobson, Stefano Moro, Zhan-Guo Gao, Giorgia Pastorin, Barbara Cacciari, Giampiero Spalluto, Katia Varani, Pier Andrea Borea, Pier Giovanni Baraldi
2002-01-01

Adenosine receptor ligands as potential therapeutics in asthma
2002-01-03

7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility
2002-02-01

Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists

Stefano Moro, Karl-Norbert Klotz, Barbara Cacciari, Giampiero Spalluto, Giorgia Pastorin
2001-12-01

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

Adriaan P IJzerman
2000-11-01

Structure and function of adenosine receptors and their genes

Linda Halldner, Björn Kull, Gunnar Schulte, Wyeth Wasserman
2000-12-01

Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen

Stefano Moro, Karl-Norbert Klotz
1999-11-01

Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors
1999-11-01

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists

Karl-Norbert Klotz
1998-01-01

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells

Martin Lohse, Karl-Norbert Klotz, Björn Kull
1998-06-01

Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists
1998-04-01

Adenosine A2B receptors: a novel therapeutic target in asthma?

Stephen T. Holgate

Artikel - wd:Q36626953

Välkommen till Inventaire

din gemenskap och vänners bibliotek

lär mer