Gunnar Schulte

1972 -

educated at: Karolinska Institutet, Freie Universität Berlin

occupation: researcher

official website: ki.se/en/people/gunsch

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Articles 77

Date

Title

Authors

2021-09-01

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

Yitian Zhou, Ainoleena Turku, Souren Mkrtchian, Kristi Krebs, Yi Wang, Barbora Svobodová, Lili Milani, Gunnar Schulte, Jan Korábečný, Stefano Gastaldello, Volker M. Lauschke
2021-11-10

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

Hannes Schihada, Ainoleena Turku, Thomas Huber, Thomas P Sakmar, Gunnar Schulte
2021-06-24

Residue 6.43 defines receptor function in class F GPCRs

Ainoleena Turku, Paweł Kozielewicz, Carl-Fredrik Bowin, Gunnar Schulte
2021-10

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Debbie Hay, Adriaan P IJzerman, Duuamene Nyimanu, Chengcan Yao, Simon D Harding, Jane F. Armstrong, Emma L. Veale, Charles Kennedy, Paweł Kozielewicz, Bice Chini, Cyril Goudet, Pascal Dournaud, Celine Valant, Marta Fumagalli, Stefania Ceruti, Gunnar Schulte, Alistair Mathie, Jérôme Leprince, Nan Chiang, Eric R Prossnitz, Anthony P Davenport, Justo P. Castaño, Trent M. Woodruff, Arthur Christopoulos, Raul Gainetdinov, Daniel Hoyer, Leigh A Stoddart, Patrick Vanderheyden, Adam J Pawson, Khuraijam Dhanachandra Singh
2020-01-21

Structural insight into small molecule action on Frizzleds

Paweł Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, Julian Petersen, Maria Consuelo Alonso Cañizal, Gunnar Schulte
2020-05-07

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

Paweł Kozielewicz, Hannes Schihada, Pradhipa Karuna M, Julia Christina Gross, Michael Boutros, Gunnar Schulte, Gary Davidson
2019-02-08

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Shane C Wright, Paweł Kozielewicz, Carl-Fredrik Bowin, Maria Marti-Solano, Mohan Madan Babu, Nevin A Lambert, Gunnar Schulte
2019-10-07

Molecular Pharmacology of Class F Receptor Activation

Paweł Kozielewicz, Ainoleena Turku, Gunnar Schulte
2019-11-01

Wnt-3a Induces Cytokine Release in Human Mast Cells

Gunnar Schulte, Gunnar Nilsson, Elin Rönnberg
2019-11-09

A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine

Paweł Kozielewicz, Carl-Fredrik Bowin, Ainoleena Turku, Gunnar Schulte
2019-03-29

Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?

Gunnar Schulte, Paweł Kozielewicz
2019-06-24

WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins

Carl-Fredrik Bowin, Gunnar Schulte
2018-10-11

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization

Ondrej Bernatik, Zbyněk Zdráhal, Vítězslav Bryja, Gunnar Schulte, Ranjani Sri Ganji, Jana Valnohova, Jakub Harnos
2018-12-04

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs

Shane C Wright, Maria Consuelo Alonso Cañizal, Tobias Benkel, Christian LeGouill, Pierre Matricon, Yoon Namkung, Viktoriya Lukasheva, Stéphane A Laporte, Evi Kostenis, Michel Bouvier, Gunnar Schulte, Carsten Hoffmann, Gabriele M. König
2018-07-23

Frizzleds as GPCRs - More Conventional Than We Thought!

Gunnar Schulte, Shane C Wright
2018-09-20

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment

Gunnar Schulte
2017-08-09

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

Gunnar Schulte, Julian Petersen, Jens Carlsson, Shane C Wright
2017-01-24

FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis

Gunnar Schulte, Mathias Uhlén, Jan Mulder
2017-12-01

WNT signalling: mechanisms and therapeutic opportunities

Gunnar Schulte
2017-06-29

The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled

Ernest Arenas, Jens Carlsson, Gunnar Schulte, Ondrej Bernatik, Vítězslav Bryja, Elisa Arthofer
2016-08-02

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins

Ondrej Bernatik, Katerina Hanakova, Stephane Angers, Gunnar Schulte, Ales Hampl, Vítězslav Bryja, Igor Cervenka, Jana Valnohova, Jakub Harnos
2016-07-25

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

Julian Petersen, J. Silvio Gutkind, Gunnar Schulte, Elisa Arthofer
2015-01-28

Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway

Julian Petersen, Gunnar Schulte, Marketa Kaucka, Jean-Paul Borg, Vítězslav Bryja, Tomasz Radaszkiewicz, Pavlína Janovská, Lucie Smyčková
2015-01-20

Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs

Jacomijn Petronella Dijksterhuis, Gunnar Schulte
2015-05-20

Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics

Gunnar Schulte
2015-12-02

CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle

Gunnar Schulte, Karl Olsson, Eric Rullman, Thomas Gustafsson
2015-06-12

WNT signaling in microglia and the glioma microenvironment

Gunnar Schulte
2015-10-25

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes

Gunnar Schulte, Mathias Uhlén, Jan Mulder
2014-03-01

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

Jacomijn Petronella Dijksterhuis, Julian Petersen, Gunnar Schulte
2014-02-05

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

Julian Petersen, Gunnar Schulte, Kjetil Wessel Andressen, Jens Schuster, Vítězslav Bryja, Ranjani Sri Ganji, Michaela B C Kilander
2014-05-27

Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity.

Gunnar Schulte
2013-07-23

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene

Gunnar Schulte

Human - wd:Q37830462

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