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The Mitochondrial Basis of Aging

author

Richard J. Youle

1952 -

published in: Molecular Cell

date of publication: 2016-03-01

Cites articles 141

Date

Title

Authors

2016-01-01

Mitochondrial Quality Control as a Therapeutic Target
2015-11-19

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

Lena F Pernas, Luca Scorrano
2015-11-04

Measuring In Vivo Mitophagy

Kira Holmström
2015-10-08

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

George L Sutphin, Anthony S Castanza, Zhongjun Zhou, Brian K Kennedy
2015-08-12

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Chunxin Wang, Michael Lazarou, Richard J. Youle, Jonathon L Burman, Lesley Kane, Danielle A Sliter, Adam I Fogel, Shireen A Sarraf
2015-07-20

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
2015-07-01

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Alicia M Pickrell, Alban Ordureau, Jeffrey W. Harper
2015-06-25

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Johan Auwerx, Keir Menzies
2015-05-28

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

Pekka Ellonen, Maija Lepistö, Michael P. Murphy
2015-05-15

The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications

Edward A. Fon
2015-05-11

Cachexia and sarcopenia: mechanisms and potential targets for intervention

Josep M. Argilés, Sílvia Busquets, Britta Stemmler, Francisco Javier López-Soriano
2015-05-13

New roles for mitochondrial proteases in health, ageing and disease

Carlos López Otín, Pedro M Quirós
2015-05-11

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity

Richard M Monaghan, Tereza Andreou, Gino Poulin, Alan J Whitmarsh
2015-04-20

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Nektarios Tavernarakis
2015-04-07

UPR(mt)-mediated cytoprotection and organismal aging
2015-04-02

Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Pekka Katajisto, Nalle Pentinmikko, Walter W Chen, David M. Sabatini
2015-03-01

Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
2015-03-12

Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)

Christopher J Fiorese
2015-02-26

Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter

Samuel A Hasson, Chunxin Wang, Richard J. Youle, Sabrina M Heman-Ackah, Adam I Fogel
2015-04-23

Mitochondrial DNA stress primes the antiviral innate immune response

A. Phillip West, Michal C Tal, James Smiley, Akiko Iwasaki
2015-01-01

The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease

Alicia M Pickrell
2015-12-02

LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

David A. Dougan, Kaye N Truscott, Erica J Brodie
2015-08-05

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.

Ulrike Topf, Andrzej Dziembowski, Bettina Warscheid, Piotr Chroscicki, Agnieszka Chacińska, Marta Koblowska, Seweryn Mroczek, Piotr Bragoszewski, Maciej Lirski
2015-06-01

ATP citrate lyase improves mitochondrial function in skeletal muscle
2014-12-18

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

Rommel A. Mathias, Yibin Kang
2014-12-01

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA

A. Phillip West, Saquib A. Lakhani, Zhijian J Chen, Richard Flavell, Akiko Iwasaki
2014-12-01

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

Kate McArthur, Michael J. White, Mark F van Delft, Sammy Bedoui, Matthew E Ritchie, Marco J Herold, Benjamin T. Kile, John Cambier, Donald Metcalf
2014-12-10

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

Justin R. Cross, Lydia Finley, Charles David Allis, Craig B. Thompson
2014-11-04

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

Aswin Mangerich, Morten Scheibye-Knudsen, Evandro F Fang, Linda H Bergersen, David Le Couteur, Rafael de Cabo, Mark Mattson, Vilhelm A. Bohr, Victoria Cogger, Alessandra Warren
2014-11-01

Stem cells and the impact of ROS signaling
2014-09-10

Mitochondrial involvement and impact in aging skeletal muscle

Russell T Hepple
2014-09-28

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

Natalia Kirienko, Christopher J Fiorese

Article - wd:Q36654160

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