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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

author

William G. Kaelin

1957 -

published in: Genes & Development

date of publication: 2013-04-01

Cites articles 181

Date

Title

Authors

2013-04-04

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

Virginie Penard-Lacronique, Cyril Quivoron, Stéphane de Botton
2013-04-04

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells

Nicolaos Palaskas, Sevin Turcan, Christian Grommes, Carl Campos, Cameron Brennan, Thomas Graeber, Ingo K Mellinghoff
2013-04-01

Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas

Tarik Tihan, Daniel Gorovets, Chao Lu, Arie Perry, Craig B. Thompson
2013-02-07

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

William G. Kaelin, David E Root, Glenn S Cowley
2013-02-21

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.

Arne H Smits, Rolf Boelens, Hugo van Ingen, Thomas Carell, Michiel Vermeulen, Christina Bauer, Markus Müller, Jörn Walter
2012-09-17

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo
2012-12-21

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization

Patrick S. Ward, Justin R. Cross, Omar Abdel-Wahab
2012-12-01

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system

Marian Mellén, Pinar Ayata, Skirmantas Kriaucionis, Nathaniel Heintz
2012-12-01

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Carlos Sebastian, Melissa Gymrek, Joanne Edwards, Ralph Weissleder, Paul G Shiels, David B. Lombard, Aviv Regev, Alon Goren, Bradley Bernstein
2012-11-30

Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas

Zachary J Reitman, Christopher G Duncan, , Roger E McLendon
2012-10-31

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation

Richard G Everson, Linda Liau, Timothy F. Cloughesy, Albert Lai, Julia M Selfridge, Mira Zurayk, Heidi Phillips
2012-10-12

HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation
2012-09-27

Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma

Shugaku Takeda, Ying-Bei Chen, Jonathan A. Coleman, Omar Abdel-Wahab, Robert Motzer
2012-10

Mitochondria and cancer
2012-09-06

The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma

Paul J Farrell
2012-08-27

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

Anjana Rao
2012-09-01

Aiding and abetting roles of NOX oxidases in cellular transformation

Yves Gorin
2012-08-20

IDH mutations in acute myeloid leukemia
2012

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase

Wolf Reik, Michael J Booth, Dario Beraldi, Miguel R Branco, Shankar Balasubramanian
2012-05-01

Nutritional regulation of insulin secretion: implications for diabetes
2012-08-08

FTO levels affect RNA modification and the transcriptome

Ludger Klein-Hitpass
2012-07-20

Role of key regulators of the cell cycle in maintenance of hematopoietic stem cells
2012-07-18

Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia
2012-08-01

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Anne Brüstle, Guido Reifenberger, Andrew Wakeham, Tak W Mak, Joshua Munger
2012-12

Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis

Liang Huang, Zhen Shang
2012-05-01

Links between metabolism and cancer
2012-03-22

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation
2012-04-20

TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group

Claus-Henning Köhne, Konstanze Döhner, Hartmut Döhner, Ulrich Germing
2012-06-01

HIF-prolyl hydroxylases and cardiovascular diseases

Nilanjana Maulik
2012-02-01

Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia

Hagop Kantarjian
2012-03-06

Progress in understanding 2-hydroxyglutaric acidurias
2012-03-27

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells

Article - wd:Q36832167

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