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Inhibitors of the heat shock response: biology and pharmacology

author

Paul Workman

published in: FEBS Letters

date of publication: 2007-05-25

language: English

main subject: pharmacology

Cites articles 74

Date

Title

Authors

2007-04-01

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

Chrisostomos Prodromou, Xavier Barril, Laurence Pearl, Keith Jones, Florence Raynaud, Nicolas Foloppe, Anthea Hardcastle
2007-01-01

An acetylation site in the middle domain of Hsp90 regulates chaperone function

Len Neckers, Bradley T Scroggins, Kristin Beebe
2007-03-01

In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

Chrisostomos Prodromou, Laurence Pearl, Richard Marais, Florence Raynaud, Paul Workman, Wynne Aherne, Kwai-Ming J. Cheung, Kathy Boxall
2006-02-17

Heat shock proteins in cancer: chaperones of tumorigenesis
2006-12-01

Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

Paul Workman
2006-11-01

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism

Charles Erlichman
2006-05-01

Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
2006-09-28

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

Gabriela Chiosis, Kimberly Stegmaier, Todd Golub, William C Hahn
2006-02-01

Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors

Michael Y Sherman, Vladimir L. Gabai
2006-08-01

Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer

Stefania Ciafrè
2006-02-09

Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death
2006-01-01

Inhibitors of the HSP90 molecular chaperone: current status

Paul Workman
2006-01-01

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

Gabriela Chiosis
2006-04-01

Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma

Francois Ghiringhelli, Eric Solary, Guido Kroemer
2006-11-07

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.
2006-01-01

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

Gabriela Chiosis
2006-08-01

Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors

Boglarka Gyurkocza, Massimiliano Meli, Giorgio Colombo, Dario C Altieri
2006-11-17

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

Cemal Gurkan, Atanas Koulov, Jeffery W. Kelly
2006

Structure and mechanism of the Hsp90 molecular chaperone machinery
2006-12-01

Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead

Massimiliano Meli, Marzia Pennati, Maria Grazia Daidone, Nadia Zaffaroni, Giorgio Colombo
2005-08-01

Heat shock response modulators as therapeutic tools for diseases of protein conformation
2005-10-01

Sick chaperones, cellular stress, and disease

Everly Conway de Macario
2005-10

HSP90 and the chaperoning of cancer
2005-10-01

The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways

Luke Whitesell
2005-11-01

Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin
2005-09-01

Attenuation of chronic thermotolerance by KNK437, a benzylidene lactam compound, enhances thermal radiosensitization in mild temperature hyperthermia combined with low dose-rate irradiation
2005-03-01

Hsp70 chaperones: cellular functions and molecular mechanism
2005-09-19

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation
2005-10-01

Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models

Paul Workman, Udai Banerji, Ian Judson
2005-06-01

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies.

Udai Banerji, Paul Workman, Simon Pacey
2005-11-01

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition
2005-07-01

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Chrisostomos Prodromou, Laurence Pearl, Paul Workman, Kwai-Ming J. Cheung

Article - wd:Q36845355

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