Jeffery W. Kelly

1960 -

country of citizenship: United States of America

languages spoken, written or signed: English

educated at: University of North Carolina at Chapel Hill, State University of New York at Fredonia

occupation: chemist, university teacher, biochemist, scientist

award received: Gabbay Award, Vincent du Vigneaud Award, Murray Goodman Memorial Prize, Ralph F. Hirschmann Award in Peptide Chemistry, Jeremy Knowles Award

Jeffery W. Kelly (born August 23, 1960 in Medina, New York) is an American businessman and chemist who is on the faculty of the Scripps Research Institute in La Jolla, California. Source: Wikipedia (en)

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Articles 235

Date

Title

Authors

2020-08-18

Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma

Evan T Powers, Jeffery W. Kelly
2020-08-31

Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery

Suhua Li, Karl Barry Sharpless, Jeffery W. Kelly
2020-12-04

Response

Jeffery W. Kelly
2019-01-14

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Lars Plate, Jeffery W. Kelly
2019-01-07

Correction to "Mispacking of the Phe87 Side Chain Reduces the Kinetic Stability of Human Transthyretin"

Xun Sun, Jeffery W. Kelly, H. Jane Dyson, Peter Wright
2019-01-01

A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence

Bryan J Lampkin, Cecilia Monteiro, Evan T Powers, Jeffery W. Kelly, Brett VanVeller
2019-08-14

The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains

Enrico Rennella, Jeffery W. Kelly, Lewis E. Kay
2018-02-13

The unfolded protein response regulator ATF6 promotes mesodermal differentiation

Lars Plate, Evan T Powers, Heike Kroeger, Neil Grimsey, Ryan Paxman, Wei-Chieh Chiang, Peter X Shaw, Stephen H Tsang, Jeffery W. Kelly, R. Luke Wiseman, Jonathan H Lin
2018-04-19

Mechanism of Action of the Cytotoxic Asmarine Alkaloids

Ryan A. Shenvi, Jeffery W. Kelly
2018-08-07

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

Ryan Paxman, Lars Plate, Evan T Powers, R. Luke Wiseman, Jeffery W. Kelly
2018-07-10

The two shapes of the Tau protein

Jeffery W. Kelly
2018-07-18

NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations

Benjamin I Leach, Xin Zhang, Jeffery W. Kelly, H. Jane Dyson, Peter Wright
2018-12-14

Mispacking of the Phe87 Side Chain Reduces the Kinetic Stability of Human Transthyretin

Xun Sun, Marcus Jaeger, Jeffery W. Kelly, H. Jane Dyson, Peter Wright
2018-07-31

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

Lars Plate, Jeffery W. Kelly
2017-06-02

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis.

Lars Plate, Jeffery W. Kelly
2017-09-06

Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency

Jeffery W. Kelly, Chi-Huey Wong
2017-06-27

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer

Saikat Chowdhury, Joseph D Schonhoft, Lars Plate, R. Luke Wiseman, Jeffery W. Kelly
2017-05-26

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors

Ian Andrew Wilson, Jeffery W. Kelly
2017-09-01

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients

Lars Plate, Evan T Powers, Joseph D Schonhoft, Cecilia Monteiro, Yvonne S Eisele, Jeffery W. Kelly, Daniel Boland, Benjamin Cravatt, Sergio Teruya, Stephen Helmke, Mathew S Maurer, John L Berk, Yoshiki Sekijima, Marta Novais, Teresa Coelho
2017-11-01

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology.

Mathieu Lavallée-Adam, Eliezer Masliah, Jeffery W. Kelly
2017-08-30

Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation

Kwang Hun Lim, Ivan Hung, Jeffery W. Kelly, Michael C Fitzgerald
2017-11-28

Translation efficiency is maintained at elevated temperature in E. coli.

Jeffery W. Kelly
2017-07-19

Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities.

Maziar S Ardejani, Jeffery W. Kelly
2017-05-04

An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils

Fernando L. Palhano, Marcela Cristina de Moraes, Débora Foguel, Jeffery W. Kelly
2017-12-04

Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?

Gareth J Morgan, Grace A Usher, Jeffery W. Kelly
2017-12-21

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

Ian Andrew Wilson, Benjamin Cravatt, Hua Wang, Stefano Forli, Lars Plate, Karl Barry Sharpless, Jeffery W. Kelly
2017-12-05

Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis.

Jeffery W. Kelly
2016-06

Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

Violaine Planté-Bordeneuve, Richard Labaudinière, Jeffery W. Kelly, Giampaolo Merlini
2016-02-12

High-Resolution Mapping of the Folding Transition State of a WW Domain

Martin Gruebele, Jeffery W. Kelly
2016-02-06

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases

Jeffery W. Kelly
2016-05-18

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

Benjamin Cravatt, Yu Liu, Lars Plate, Evan T Powers, Karl Barry Sharpless, Jeffery W. Kelly
2016-06-01

The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate

H. Jane Dyson, Evan T Powers, Jeffery W. Kelly, Chi-Huey Wong

Human - wd:Q6175781

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