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Protein aggregates in Huntington's disease.

author

Montserrat Arrasate

published in: Experimental Neurology

date of publication: 2011-12-19

language: English

main subject: Huntington's disease

Cites articles 136

Date

Title

Authors

2011-01-05

A compact beta model of huntingtin toxicity

L. Mario Amzel, Yujin E Kim, J Alfonso Leyva, Jason M. Miller, Christopher A Ross
2011-05-29

Kinase inhibitors modulate huntingtin cell localization and toxicity

Tamara Maiuri
2010-09-10

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

Jason M. Miller, Montserrat Arrasate, Andrey S. Tsvetkov
2010-08-01

Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis

Eliezer Masliah
2010-05-21

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

Gilles Bonvento, Emmanuel Brouillet, Nicole Déglon, Robert J Ferrante, Philippe Hantraye, Martine Guillermier, Mathilde Faideau, Gwennaëlle Auregan
2010-05-05

Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool

Andrew F. Hill, Danny M. Hatters
2010-04-29

Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences

Feng Ding, Nikolay V. Dokholyan
2010-04-27

Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.

Solomon Halbert Snyder
2010-04-01

Conformation sensors that distinguish monomeric proteins from oligomers in live cells
2010-04-11

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

Ana María Cuervo, Esperanza Arias, Esther Wong, Marta Martinez-vicente, Dave Soldier
2010-03-01

Protein palmitoylation in neuronal development and synaptic plasticity
2010-01-01

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

Rochelle Hines, Mahmoud A. Pouladi, Lynn A Raymond, Michael R. Hayden
2010-03-05

The evolutionarily conserved interaction between LC3 and p62 selectively mediates autophagy-dependent degradation of mutant huntingtin
2010-03-01

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation

Nico P. Dantuma, José J. Lucas, Miguel Diaz-Hernandez, Felix Hernandez
2010-09-01

Selective autophagy: ubiquitin-mediated recognition and beyond

Claudine Kraft, Matthias Peter
2009-12-01

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice
2009-12-21

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Michael R. Hayden, Marta Martinez-vicente, Montserrat Arrasate, Gillian Bates, Ana María Cuervo, Donald C. Lo, Linda S. Kaltenbach
2009-11-15

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

Michael R. Hayden, Marcus Kaul, Stuart A. Lipton
2009-08-26

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity
2009-07-30

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

Bogdan I Florea, Jia-Yi Li, Nico P. Dantuma, José J. Lucas, Sam Brundin
2009-07-01

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

Erik D. Roberson, Susan Lindquist, Eliezer Masliah
2009-06-05

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

Solomon Halbert Snyder
2009-06-02

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment
2009-05-01

A role for ubiquitin in selective autophagy

Vladimir Kirkin, David G McEwan, Ivana Novak, Ivan Đikić
2009-04-10

Mouse models of Huntington's disease and methodological considerations for therapeutic trials

Robert J Ferrante
2009-03-05

Huntingtin as an essential integrator of intracellular vesicular trafficking
2009-11-15

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

Judith Frydman
2009-04-01

Acetylation targets mutant huntingtin to autophagosomes for degradation
2009-03-01

In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease
2009-03-08

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

James F. Conway, Angela Gronenborn
2008-12-10

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease

Andrey S. Tsvetkov
2008-12-01

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

Xuejun Wang

Article - wd:Q37540988

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