James A Irving - 著者 - Inventaire

James A Irving

職業: 研究者

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記事 55

Date

タイトル

著者

2021-03-04

Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes

James A Irving, Wilson L W Tan
2020-10-15

The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone

Riccardo Ronzoni, Annamaria Fra, Elena Miranda, James A Irving
2020-10-21

The structural basis for Z α1-antitrypsin polymerization in the liver

Sarah V Faull, Emma L K Elliston, Bibek Gooptu, Alistair M Jagger, Adam Redzej, Magd Badaoui, Nina Heyer-Chauhan, Sheikh T. Rashid, Gary Reynolds, David Adams, Elena V. Orlova, James A Irving, David Lomas
2020-12-11

High-resolution ex vivo NMR spectroscopy of human Z α<sub>1</sub>-antitrypsin

Christopher A Waudby, James A Irving, John Christodoulou
2019-01-11

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population

Mattia Laffranchi, Fabrizio Gangemi, James A Irving, Annamaria Fra
2018-02-01

Probing the folding pathway of a consensus serpin using single tryptophan mutants.

James A Irving, Marie-Isabel Aguilar, Stephen P Bottomley
2017-05-15

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization

Elena Miranda, James A Irving, Mattia Laffranchi, Stefania Ottaviani, Annamaria Fra
2015-03-10

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity

James A Irving, Stefan Marciniak
2015-06-19

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

Aarash Saleh, James A Irving, Bibek Gooptu
2015-10-03

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

Bibek Gooptu, James A Irving, Vincenzo Martorana, Mauro Manno, Stefan Marciniak, Elena Miranda
2015-05-01

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

James A Irving
2015-07-14

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

James A Irving, Jemma Day, Bibek Gooptu
2014-05-01

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

James A Irving
2014-11-13

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

James A Irving, Stefan Marciniak, Bibek Gooptu
2013-05-31

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

James C Whisstock, Pascal G Wilmann, Andrew J. Perry, Lakshmi Wijeyewickrema, Jacqueline A. Wilce, James A Irving, Robert N. Pike, Menachem J Gunzburg
2013-08-02

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity

Elena Speretta, James A Irving, Stefan Marciniak, Damian C Crowther
2013-06-25

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

James A Irving, Bibek Gooptu
2012-01-01

Phosphoproteins in stress-induced disease

James A Irving, Stefan Marciniak, Eleanor Healey
2011-01-01

Targeting serpins in high-throughput and structure-based drug design

Irene Nobeli, James A Irving, Konstantinos Thalassinos, Elena Miranda, Bibek Gooptu
2011-06-20

Unravelling the twists and turns of the serpinopathies

James A Irving, Stefan Marciniak, Benoit D Roussel, Sheikh T. Rashid, Damian C Crowther
2011-01-01

The serpinopathies studying serpin polymerization in vivo

James A Irving, Elena Miranda, Stefan Marciniak, Bibek Gooptu, Jeffrey Teckman, Ludovic Vallier, Edwin R Chilvers, Benoit D Roussel
2010-04-06

MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography

Cyril F Reboul, James A Irving, Ashley Buckle, James C Whisstock, Arun S Konagurthu, Arthur M. Lesk, Peter J Stuckey
2010-11-27

Characterisation of serpin polymers in vitro and in vivo

Elena Miranda, James A Irving, Stefan Marciniak, Benoit D Roussel, キャロル・V・ロビンソン, Damian C Crowther
2009-04-07

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

James C Whisstock, Kris Gevaert, Joël Vandekerckhove, Petra Van Damme, James A Irving, Philip E. Thompson, Phillip I. Bird, Ashley Buckle, Ruby H Law, Tanya A Bashtannyk-Puhalovich, Chris G Langendorf, Dion Kaiserman
2009-07-24

Structural mechanisms of inactivation in scabies mite serine protease paralogues

James C Whisstock, Christopher Langendorf, Sheena McGowan, James A Irving, Robert N. Pike, Ashley Buckle, David Kemp, Ruby H Law, Tanya A Bashtannyk-Puhalovich
2009-03-06

Conformational change in the chromatin remodelling protein MENT

Christopher Langendorf, Sheena McGowan, James A Irving, Robert N. Pike, James C Whisstock, Stephen P Bottomley
2009-02-20

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

David Piedrafita, Theresa Coetzer, Lakshmi Wijeyewickrema, Peter M. Smooker, James A Irving, Boris Turk, Robert N. Pike, Matthew Bogyo, Simone A Beckham
2008-02-16

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

Anna Akhmanova, James A Irving, James C Whisstock
2007-06-08

The N terminus of the serpin, tengpin, functions to trap the metastable native state

Jamie Rossjohn, Ashley Buckle, Ruby H Law, James A Irving, James C Whisstock, Stephen P Bottomley
2007-07-03

Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry

James A Irving, Ursula Dietrich
2007-10-08

DNA accelerates the inhibition of human cathepsin V by serpins

Sheena McGowan, James A Irving, Klaudia Brix, Boris Turk, Robert N. Pike, James C Whisstock, Stephen P Bottomley
2007-07-16

Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap

James A Irving, James C Whisstock, Stephen P Bottomley

Human - wd:Q37834674

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