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IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.

forfatter

Jean-Laurent Casanova

1963 -

Andrea M. Cooper

Mark J. Smyth

1963 -

Michele W.L. Teng

udgivet i: Nature Medicine

dato for udgivelse: 2015-06-29

sprog: engelsk

main subject: betændelse

Cites articles 193

Date

Titel

Forfattere

2015-02-27

Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway

Yuepeng Zhou
2014-02-20

Combined anti-CD40 and anti-IL-23 monoclonal antibody therapy effectively suppresses tumor growth and metastases

Mark J. Smyth
2014-10-01

Role of IL-17 and IL-22 in autoimmunity and cancer
2014-07-09

Secukinumab in plaque psoriasis--results of two phase 3 trials.

Bárður Sigurgeirsson, Tsen-Fang Tsai
2014-12

Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

Jean-Laurent Casanova, Laurent Abel, Stephanie Boisson-Dupuis, Jacinta Bustamante
2014-07-01

A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors
2014-02-25

Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?

Maria Sole Chimenti, Emma Guttman-Yassky, James G. Krueger, Andrea Chiricozzi
2014-05-23

Targeting the IL-12/IL-23 axis: An alternative approach to removing tumor induced immune suppression

Mark J. Smyth
2014-01-17

Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis
2014-05-08

IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L

Witold Zgodzinski, Emina H. Huang, Ilona Kryczek, Grzegorz Wallner
2014-01-03

Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS).

Johanna Callhoff, Denis Poddubnyy, Kay-Geert Hermann
2014-05-12

Human genetics of tuberculosis: a long and winding road

Jean-Laurent Casanova, Laurent Abel, Erwin Schurr
2014-05-01

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

Christopher J. Nirschl, Rajni B. Sharma, Elizabeth Jaffee, Anirban Maitra, Drew M Pardoll
2014-01-24

IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway
2014-08-01

Psoriasis

Paola Di Meglio
2014-01-01

Therapeutic opportunities of the IL-22-IL-22R1 system

Wenjun Ouyang
2014-06-01

Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis

Christopher T Ritchlin, Ngozi Erondu
2014-01-01

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

Daehee Kang, Jianjun Liu, Kyung Mo Kim, Byong Duk Ye
2014-09

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
2013-06-02

Nivolumab plus ipilimumab in advanced melanoma

Mario Sznol, Jedd D Wolchok
2013-04-01

Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up

Kim A. Papp, Christopher Griffiths
2013-04-05

The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients

Paola Di Meglio, Jonathan N. Barker, John A. Todd
2013-01-29

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial.

Iain McInnes, Désirée van der Heijde, Paul Emery, John D Isaacs, Paul P Tak, Hendrik Schulze-Koops
2013-05-22

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

Matthew R. Hepworth, Carly G K Ziegler, Adriana R Mantegazza, Alison Crawford, Pandelakis A. Koni, Frederic D. Bushman, Gérard Eberl
2013-01-16

Essentials of Th17 cell commitment and plasticity

Nicholas P. Restifo
2013-10-01

Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III).

Luisa M Villar, Alfredo Rodríguez-Antigüedad, Mar Tintoré, Guillermo Izquierdo
2013-08-13

A balance of interleukin-12 and -23 in cancer

Mark J. Smyth
2013-12-25

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Andres Metspalu, Tõnu Esko, Harm-Jan Westra, Soumya Raychaudhuri, Jane Worthington, Mark Lathrop, Pilar Galan, Gosia Trynka, Solbritt Rantapää-Dahlqvist, Barbara E. Stranger, Tushar Bhangale, Corinne Miceli-Richard, Luis Rodriguez-Rodriguez, Niek de Vries, Alexandra Zhernakova, Jian Yang, Philippe Dieudé, Matthew A. Brown, Lude Franke, Leonid Padyukov, Sang-Cheol Bae, Javier Martin, Anne Barton, Lars Klareskog, Peter M Visscher, Henk-Jan Guchelaar, Peter K. Gregersen, Hisashi Yamanaka, Paul P Tak, Tom Huizinga, Elizabeth W Karlson, Xavier Mariette, Philip L De Jager, Lindsey A. Criswell, Joshua C. Denny, Michiaki Kubo, Rene E Toes, Robert M Plenge, Eli A Stahl, Marieke J H Coenen, Piet L C M van Riel, Katherine A Siminovitch, Dorothée Diogo, Katherine P Liao, Jeffrey D Greenberg, Joel M Kremer, Ward Ortmann, Towfique Raj, Chikashi Terao, Anne E Eyler, Namrata Gupta, Daniel B Mirel, Mart Afj van de Laar, S Louis Bridges, Hye-Soon Lee, Miguel Angel Gonzalez-Gay, Hyon K Choi, Yoichiro Kamatani, Larry Moreland, Yuta Kochi, Akari Suzuki, Keiko Myouzen, Tsuneyo Mimori, Fumihiko Matsuda, Atsushi Takahashi
2013-03-01

Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds

Capucine Picard, Jean-Laurent Casanova, Jacinta Bustamante, Stephanie Boisson-Dupuis, Aurélie Cobat, Rabih Halwani, Alireza Mahdaviani, Andrew Pollard
2013-01-03

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

Chris Russell, Michelle A Lowes, James G. Krueger
2013-02-01

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study

Bárður Sigurgeirsson, Carle Paul
2013-10-25

A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

Artikel - wd:Q38539817

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