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Gene therapy returns to centre stage

author

Luigi Naldini

published in: Nature

date of publication: 2015-10-01

language: English

main subject: gene therapy

Cites articles 122

Date

Title

Authors

2015-05-01

CRISPR germline engineering--the community speaks

Jacob E Corn, Jennifer Doudna, Bartha Knoppers, Michael Botchan, Rosario Isasi, Luigi Naldini, Emmanuelle Charpentier, Craig Venter, Henry Greely, Annelien Bredenoord, Jin-Soo Kim, Robin Lovell-Badge
2015-05-05

Improving the safety of cell therapy with the TK-suicide gene

Luca Vago, Iacopo Peccatori, Nicoletta Cieri, Maria Chiara Bonini, Fabio Ciceri
2015-02-01

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

Serena Scala, Andrea Calabria, Nicoletta Cieri, Caterina Cancrini, Maria Grazia Roncarolo, Eugenio Montini, Maria Chiara Bonini, Alessandro Aiuti
2015-04-03

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

Jonathan J Havel, Phillip Wong, Martin L Miller, Roberta Zappasodi, Ton Schumacher, Jedd D Wolchok, Chris Sander
2015-03-01

$1-million price tag set for Glybera gene therapy
2015-04-01

In vivo genome editing using Staphylococcus aureus Cas9

Jonathan S. Gootenberg, Xuebing Wu, Eugene Koonin, Kira Makarova, Winston X Yan, Bernd Zetsche
2015-01-28

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

Katie J. Ewer, Tommy Rampling, Georgina Bowyer, Ruth O Payne, Nick J Edwards, Emma M Bentley, Geneviève M C Labbé, Malick Gibani, Richard S Tedder, Iris De Ryck, Simon J. Draper, Stephan Becker, Myron M. Levine, Sarah Gilbert, W Ripley Ballou, Barney S. Graham, Verena Krähling, François Roman, Richard A Koup, Andrew Pollard, Adrian V. S. Hill, Nancy Sullivan, Daphne A. Stanley, Alison M. Lawrie, Teresa Lambe, Eleanor Berrie, Carly M Bliss, Richard M Schwartz, Egeruan B Imoukhuede, Ian Poulton, Stefano Colloca, Alfredo Nicosia, Claire M Tully, Kailan Sierra-Davidson, Jonathan Powlson, Loredana Siani, Antonella Folgori, Thomas Strecker
2015-05-01

Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

Georgina Bowyer, Nick J Edwards, Evelyn Gitau, Britta C Urban, Susanne H Hodgson, Kevin Marsh, Philip Bejon, Adrian V. S. Hill, Carly M Bliss, Katie J. Ewer, Alison M. Lawrie, Nicola K. Viebig, Egeruan B Imoukhuede, Domtila Kimani, Alfredo Nicosia, Jedidah Mwacharo, Caroline Ogwang, MVVC group
2015-05-04

Long-term effects of retinal gene therapy in childhood blindness
2015-01-20

Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy

Randy Chandler, Matthew C LaFave, Gaurav K. Varshney, Nuria Carrillo-Carrasco, Shawn M. Burgess
2015-02-01

Fanconi anemia gene editing by the CRISPR/Cas9 system

Jakub Tolar, Amber N McElroy, Colby Starker, Daniel F Voytas, Manfred Schmidt, J. Keith Joung, Christof von Kalle, Bruce R Blazar
2015-04-03

The future of immune checkpoint therapy

James P. Allison
2015-03-02

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

Gregory J Cost, Aaron Cooper, Andrew Wilber, Donald B. Kohn, Megan D Hoban, Zulema Romero, Michael L Kaufman, Michelle Ho, David Gray, Georgia R Lill, Philip D Gregory, Edward Rebar, David E Paschon, Andreas Reik, Pei-Qi Liu
2015-05-04

Long-term effect of gene therapy on Leber's congenital amaurosis

James W. Bainbridge, Anastasios Georgiadis, Freya M Mowat, Peter J Gardner, Nick Tyler, Marko Nardini, Simon M Petersen-Jones
2015-03-01

Adoptive cellular therapy: a race to the finish line

Ton Schumacher, Carl H. June
2015-02-01

Therapeutic genome editing: prospects and challenges

Randall J. Platt
2015-03-01

Liver-directed lentiviral gene therapy in a dog model of hemophilia B.

Alessio Cantore, Eugenio Montini, Luigi Naldini, Armando D'Angelo, Claudio Doglioni, Manfred Schmidt
2015-05-03

Improvement and decline in vision with gene therapy in childhood blindness

Samuel G. Jacobson, William W Hauswirth, Elise Héon
2015-08-24

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

Jessica Zucman-Rossi, Paulette Bioulac-Sage, Camilla Pilati, Eric Letouzé, Sandrine Imbeaud, Alexis Laurent
2015-04-03

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

Paul Berg, David Baltimore, George M. Church, Jennifer Doudna, Martin Jínek, George Q. Daley, Michael Botchan, Henry Greely, Jonathan Weissman, Jennifer M Puck, Samuel H Sternberg
2015-04-01

Adoptive cell transfer as personalized immunotherapy for human cancer

Nicholas P. Restifo, Steven Rosenberg
2015-06-01

Gene therapy outpaces haplo for SCID-X1.

Donald B. Kohn
2015-04-01

Neoantigens in cancer immunotherapy

Ton Schumacher
2015-05-05

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma

Joal D Beane, Smita S Chandran, Dmitry Guschin, Philip D Gregory, Nicholas P. Restifo, Steven Rosenberg, Zhili Zheng, Steven R. Feldman, Daniel Abate-Daga, Edward Rebar, David E Paschon, Andreas Reik
2015-04-01

Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndrome

Alain Fischer, Marina Cavazzana-Calvo, Salima Hacein-Bey-Abina, Jean-Marc Tréluyer, Capucine Picard, Laure Caccavelli, Sébastien Héritier, Emmanuelle M. Six, Fabien Touzot, Fulvio Mavilio, Adrian Thrasher
2014-05-23

Targeted gene therapy and cell reprogramming in Fanconi anemia

Paula Río, Rocío Baños, Angelo Leone Lombardo, Oscar Quintana-Bustamante, Pietro Genovese, Rodolfo Murillas, Jordi Surrallés, Philip D Gregory, Luigi Naldini
2014-12-16

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Zongli Zheng, Martin J. Aryee, J. Keith Joung
2014-01-10

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

Claire Thiriez, Xavier Drouot, Bijan Ghaleh, Philippe Le Corvoisier, Roger A. Barker, Philippe Remy, Philippe Hantraye
2014-03-06

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

Pablo Tebas, Philip D Gregory, Ronald G Collman, Carl H. June, Bruce L. Levine
2014-07-03

Going viral with cancer immunotherapy

John C Bell, David F Stojdl, Brian Dennis Lichty
2014-10-16

Chimeric antigen receptor T cells for sustained remissions in leukemia

Yolanda Mahnke, David T Teachey, Carl H. June, David L. Porter, Bruce L. Levine, Stephan A Grupp, Simon F Lacey, Noelle V. Frey, Shannon L Maude, Richard Aplenc, Nancy J Bunin, Sue Anne Chew, Vanessa Gonzalez-Covarrubias, Jan Melenhorst, Susan R Rheingold
2014-10-13

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Steven Rosenberg

Article - wd:Q38607706

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