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Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins

published in: International journal of Alzheimer's disease

date of publication: 2010-12-20

main subject: membrane raft

Cites articles 122

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MEGF10 functions as a receptor for the uptake of amyloid-β.
2010-08-04

Statins for the treatment of dementia

Bernadette McGuinness
2010-07-29

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking

Rodrigo A Fuentealba, Jin-Moo Lee, Mary J LaDu
2010-07-27

Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property

Jorge Parodi, Carlos Opazo
2010-02-01

Inflammation in neurodegenerative diseases
2010-03-10

Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease
2010-05-17

Endocytic pathways mediating oligomeric Abeta42 neurotoxicity

Mary J LaDu
2010-05-06

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines
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Alzheimer's disease: strategies for disease modification
2010-08-01

Lipid membranes and beta-amyloid: a harmful connection
2010-04-22

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Leslie Crews, Eliezer Masliah
2010-11-01

An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42
2010-03-26

Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution
2010-03-18

Membrane rafts in Alzheimer's disease beta-amyloid production
2010-03-10

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

Roberta Cascella, Giovanna Cenini, Daniela Uberti, Matteo Becatti, Cristina Cecchi, Maurizio Memo, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Mariagioia Zampagni, Elisa Evangelisti, Gianfranco Liguri, Anna Pensalfini
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Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
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Co-segregation of AMPA receptors with G(M1) ganglioside in synaptosomal membrane subfractions

Andy A Cole
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beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts
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Transgenic mouse models of Alzheimer's disease
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Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption

Xiaohua Douglas Zhang
2009-11-24

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction
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Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake
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The role of apolipoprotein E in Alzheimer's disease

David M. Holtzman
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Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

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Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

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Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors
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The interaction of beta-amyloid protein with cellular membranes stimulates its own production
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HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin
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Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

David M. Holtzman
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Article - wd:Q41487372

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