Florian Nigsch

pendidikan: Universitas Cambridge

pekerjaan: peneliti

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Artikel 38

Date

Judul

Pengarang

2021-09-29

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

Florian Nigsch
2019-10-14

IRF2 is a master regulator of human keratinocyte stem cell fate

Nicolas Mercado, Gabi Schutzius, Christian Kolter, David Estoppey, Sebastian Bergling, Guglielmo Roma, Florian Nigsch, Adrian Salathe, Remi Terranova, Dominic Hoepfner, Alexandra Aebi, Mathias Frederiksen, Charles Y Lin, Susan Kirkland, John S Reece-Hoyes
2019-05-09

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Florian Nigsch, John S Reece-Hoyes, Guglielmo Roma
2019-07-17

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

Florian Nigsch, Caroline Gubser Keller, Guglielmo Roma
2019-11-08

Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model

Florian Nigsch, Guglielmo Roma
2018-12-27

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

Annemarie Voorberg-van der Wel, Florian Nigsch, Walter Carbone, Devendra Kumar Gupta, Erika L Flannery, Jetsumon Sattabongkot, Thierry Tidiane Diagana, Clemens Kocken, Guglielmo Roma
2017-08-24

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

Barna D Fodor, Florian Nigsch, Ieuan Clay, John S Reece-Hoyes, Dirk Schübeler
2017-12-21

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.

Walter Carbone, Florian Nigsch, John S Reece-Hoyes, Guglielmo Roma
2017-12-07

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

Annemarie Voorberg-van der Wel, Guglielmo Roma, Devendra Kumar Gupta, Florian Nigsch, Walter Carbone, Pablo Bifani, Clemens Kocken, Thierry Tidiane Diagana
2017-01-06

Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology

Walter Carbone, Florian Nigsch, Guglielmo Roma
2016-02-16

Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis In-house HTS Data

Andreas Bender, Florian Nigsch, Adriaan P IJzerman
2016-08-03

Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening

Andreas Bender, Florian Nigsch, Adriaan P IJzerman
2016-07-09

Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery

Florian Nigsch
2016-10-01

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Florian Nigsch, Markus H Heim, Diego Calabrese, Walter Carbone, Stuart J Forbes, Guglielmo Roma
2016-04-18

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

Luke Boulter, Florian Nigsch, Markus H Heim, Lara Planas-Paz, Diego Calabrese, Michael T. Dill, Walter Carbone, Raffaella Zamponi, Stuart J Forbes, Guglielmo Roma
2016-11-14

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

Florian Nigsch, Beat C Bornhauser, Jean-Pierre Bourquin
2014

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Annika Hohendahl, Yann Abraham, Florian Nigsch
2014-02-11

Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer

Junxia Min, Florian Nigsch, Janna Hutz
2012-05-31

Rethinking molecular similarity: comparing compounds on the basis of biological activity

Florian Nigsch, Eugen Lounkine, Peter S Kutchukian, Jeremy L. Jenkins
2012-05-10

Determination of minimal transcriptional signatures of compounds for target prediction

Florian Nigsch, Jeremy L. Jenkins, Janna Hutz
2012-01-26

Predicting the mechanism of phospholipidosis

Florian Nigsch, Robert C Glen, Hamse Y Mussa
2012-11-29

The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens

Florian Nigsch, Jeremy L. Jenkins
2011-06

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

Peter Ertl, Antony John Williams, Johann Gasteiger, Andreas Bender, Valery Tkachenko, Maria Grishina, Matthias Rupp, João Aires de Sousa, Vladimir Potemkin, Roberto Todeschini, Igor V. Tetko, Igor I. Baskin, Florian Nigsch, Gilles Marcou, Luc Patiny, Sergii Novotarskyi
2011-04-01

Recent trends and observations in the design of high-quality screening collections

Florian Nigsch, Jeremy L. Jenkins, Ansgar Schuffenhauer
2011-11-04

Computational methods for early predictive safety assessment from biological and chemical data

Florian Nigsch, Philippe Marc, Jeremy L. Jenkins
2011-12-07

Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships

Florian Nigsch, Jeremy L. Jenkins
2010-12-15

Classifying large chemical data sets: using a regularized potential function method

Robert C Glen, Florian Nigsch, Hamse Y Mussa
2010-11-01

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

Jeremy L. Jenkins, Florian Nigsch
2009-01-01

Computational toxicology: an overview of the sources of data and of modelling methods

Florian Nigsch, John Blayney Owen Mitchell
2008-02-18

A novel hybrid ultrafast shape descriptor method for use in virtual screening

Florian Nigsch, John Blayney Owen Mitchell
2008-05-16

Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases

Florian Nigsch
2008-10-29

Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction

Noel O'Boyle, David S Palmer, Florian Nigsch, John Blayney Owen Mitchell

Human - wd:Q42098378

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