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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

author

Judy Hirst

published in: Biochemical Journal

date of publication: 2014-09-01

language: English

main subject: metformin, mitochondrion, phosphorylation

Cites articles 72

Date

Title

Authors

2014-05-21

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Michael J. Jurczak, Gerald I. Shulman, Varman T Samuel, Gary W Cline, Xian-Man Zhang, Sanjay Bhanot, João Paulo Camporez, Anila K Madiraju, Richard G. Kibbey, Yasmeen Rahimi
2014-05-13

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Eric Dufour, Samuel E Weinberg, Lucas B Sullivan, Gökhan M Mutlu
2014-03-16

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Richard Possemato, Franziska K Lorbeer, Timothy C Wang, Walter W Chen, Clary B Clish, David M. Sabatini, Kıvanç Birsoy
2014-01-07

Metformin--mode of action and clinical implications for diabetes and cancer

Márta Korbonits
2013-11-01

Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

Judy Hirst
2013-07-22

A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase

Judy Hirst
2013-01-01

Metformin impairs glucose consumption and survival in Calu-1 cells by direct inhibition of hexokinase-II

Cecilia Marini, Silvia Ravera, Michela Massollo, Adriana Amaro, Mario Passalacqua, Ulrich Pfeffer, Renzo Cordera, Davide Maggi
2013-05-26

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

Linda Partridge, Edward T Chouchani, Richard C Hartley, Michael P. Murphy, Paul S. Brookes, Thomas Krieg, Kathryn Lilley
2013-03-01

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

Filipe Cabreiro, Catherine Au, David Weinkove, Eugene Schuster, Nicholas D.E. Greene, David Gems
2013-03-18

Mitochondrial complex I.

Judy Hirst
2013-02-28

Crystal structure of the entire respiratory complex I

John M Berrisford, Leonid Sazanov
2013-02-14

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Marc Foretz, Benoit Viollet, Morris J. Birnbaum
2013-03-01

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

Michael P. Murphy, Anna Dominiczak, Christian Delles, Andrea Degasperi, Ian P Salt
2013-11-01

Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties
2013-01-10

Partitioning of superoxide and hydrogen peroxide production by mitochondrial respiratory complex I

Vera Grivennikova
2012-12-05

Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria
2012-12-01

Metformin and the risk of cancer: time-related biases in observational studies
2012-09

Investigating metformin for cancer prevention and treatment: the end of the beginning
2012-08-01

The deactive form of respiratory complex I from mammalian mitochondria is a Na+/H+ antiporter

Judy Hirst
2012-07-01

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

Begoña Martin-Castillo
2012-04-23

Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil

Yongyuth Yuthavong, Sumalee Kamchonwongpaisan
2012-01-18

Metformin reduces endogenous reactive oxygen species and associated DNA damage

Xavier Deschênes-Simard, Benoit Viollet
2011-10-02

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
2011-09-16

Elucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels
2011-03-18

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

Sean M Davidson, Mihaela M Mocanu
2011-01-01

Role of solvation effects in protein denaturation: from thermodynamics to single molecules and back

Jeremy England
2011-01-07

Metformin activates AMP kinase through inhibition of AMP deaminase
2011-05-13

Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.

Wiek H van Gilst
2011-03-10

Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer

Judy Hirst
2011-06-12

A ternary mechanism for NADH oxidation by positively charged electron acceptors, catalyzed at the flavin site in respiratory complex I

Martin S King, Judy Hirst
2010-06-01

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
2009-12-01

Pharmacogenetics of antimalarial drugs: effect on metabolism and transport

Peter Gottfried Kremsner, José Pedro Gil

Article - wd:Q42848863

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