Francesco Iorio

occupation: bioinformatician

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Articles 56

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Title

Authors

2022-10-26

Phenotypic plasticity and genetic control in colorectal cancer evolution

Jacob Househam, Timon Heide, George D Cresswell, Maximilian Mossner, Ann-Marie Baker, Eszter Lakatos, Benjamin Werner, Francesco Iorio, Marnix Jansen, Giulio Caravagna, Chris Barnes, John Bridgewater, Manuel Rodriguez-Justo, Luca Magnani, Andrea Sottoriva, Trevor A Graham
2021-11-17

CoRe: a robustly benchmarked R package for identifying core-fitness genes in genome-wide pooled CRISPR-Cas9 screens

Francesco Iorio
2021-01-21

Minimal genome-wide human CRISPR-Cas9 library

Emanuel Gonçalves, Francesco Iorio, Mathew J Garnett
2021-09-15

Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma

Matteo C Da Vià, Marta Lionetti, Paolo Corradini, Ola Landgren, Francesco Iorio, Martina Manzoni, Francesco Maura, Niccolo Bolli
2021-03-12

Integrated cross-study datasets of genetic dependencies in cancer

Clare Pacini, Joshua M Dempster, Emanuel Gonçalves, James M McFarland, Mathew J Garnett, Aviad Tsherniak, Francesco Iorio
2020-07-01

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Charlotte Tolley, Francesco Iorio, Mathew J Garnett
2020-08-07

Analysis of CRISPR-Cas9 screens identify genetic dependencies in melanoma

Eirini Christodoulou, Francesco Iorio, David J Adams
2020-07-02

Identification of Intrinsic Drug Resistance and Its Biomarkers in High-Throughput Pharmacogenomic and CRISPR Screens

Francesco Iorio
2019-02-05

Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

Emanuel Gonçalves, Oliver Stegle, Francesco Iorio
2019-03

JACKS: joint analysis of CRISPR/Cas9 knockout screens

Felicity Allen, Leopold Parts, Francesco Iorio
2019-05-16

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

Elisabeth Chen, Luz Garcia-Alonso, Fiona M Behan, Emanuel Gonçalves, Ultan McDermott, Francesco Iorio, Fengtang Yang, Julio Saez-Rodriguez
2019-12-20

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

Joshua M Dempster, Clare Pacini, Fiona M Behan, John M Krill-Burger, Hanna Najgebauer, Emanuel Gonçalves, John G Doench, Francisca Vazquez, Jesse S Boehm, Todd Golub, William C Hahn, David E Root, Aviad Tsherniak, Francesco Iorio
2019-04-10

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens

Francesco Iorio, Emanuel Gonçalves, Giorgia Migliardi, Francesco Sassi, Marika Pinnelli, Piers Wilkinson, Livio Trusolino, Julio Saez-Rodriguez, Andrea Bertotti
2018-04-01

GDSCTools for Mining Pharmacogenomic Interactions in Cancer.

Francesco Iorio, Julio Saez-Rodriguez
2018-01-18

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.

Magali Michaut, Steven P. Williams, Francesco Iorio, Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Elizabeth K Sage, Ultan McDermott, Sam M Janes
2018-04-30

Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich.

Francesco Iorio, Ultan McDermott, Julio Saez-Rodriguez
2018-08-23

The germline genetic component of drug sensitivity in cancer cell lines

Johannes Stephan, Francesco Iorio, Julio Saez-Rodriguez, Ultan McDermott, Oliver Stegle
2018-08-13

Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting

Francesco Iorio, Emanuel Gonçalves, Elisabeth Chen, Rachel Pooley, Piers Wilkinson, Julio Saez-Rodriguez
2018-03-03

CELLector: Genomics Guided Selection of Cancer in vitro Models

Hanna Najgebauer, Francesco Iorio, Julio Saez-Rodriguez
2018-10-12

Drug repurposing: progress, challenges and recommendations

Philippe Sanseau, Francesco Iorio, Andrew J Doig, David Cavalla
2017-02-08

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

Steven P. Williams, Julio Saez-Rodriguez, Ultan McDermott, Carla Daniela Robles-Espinoza, Francesco Iorio, Inigo Martincorena
2017-12-11

Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer

Francesco Iorio, Nuno A. Fonseca, Ian Dunham, Julio Saez-Rodriguez, Luz Garcia-Alonso, Gareth Peat, Simon S. McDade
2017-10-23

Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition.

Francesco Iorio, Ultan McDermott, Sjaak Neefjes
2017-09-28

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

Antonia Pritchard, Anneliese O Speak, Francesco Iorio, Anton J. Enright, Ultan McDermott, Jyoti Choudhary, Julia A Newton Bishop, Theodoros I Roumeliotis, Daniel Peeper
2016-12-19

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition

Núria López-Bigas, Francesca Mateo, Miren Maicas, Francesco Iorio, Ignacio Blanco, José Lozano, Nuria Bonifaci, Margaretha A. Skowron, Julián Cerón, Joan Brunet, Joan Valls, Ana Velasco, Jose V Sanchez-Mut, Montse Sanchez-Cespedes, Jorge Gómez-Miragaya, Miguel Quintela-Fandino, Oriol Casanovas, Mariona Graupera, Javier Hernandez-Losa, Santiago Ramon y Cajal, Luz Garcia-Alonso, Julio Saez-Rodriguez, Manel Esteller, Eva Gonzalez-Suarez, Gema Moreno-Bueno, Roger Gomis, Lubomir Bodnar
2016-10-01

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, Paolo Gallipoli, Ultan McDermott, Julio Saez-Rodriguez, Brian Huntly, Francesco Iorio, Cristina Pina, George S Vassiliou, Sarah Teichmann
2016-12-20

Efficient randomization of biological networks while preserving functional characterization of individual nodes

Francesco Iorio, Marti Bernardo-Faura, Julio Saez-Rodriguez
2016-02-08

Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells

Jalid Sehouli, Probir Chakravarty, Francesco Iorio, Julio Saez-Rodriguez, Fran Balkwill, Hagen Kulbe, Carla S Milagre, Gemma L A Everitt
2016-07-07

A Landscape of Pharmacogenomic Interactions in Cancer

Núria López-Bigas, Francesco Iorio, Michael Schubert, Emanuel Gonçalves, Howard Lightfoot, Holger Heyn, Sebastian Moran, Sergi Sayols, Manel Esteller, Julio Saez-Rodriguez, Ultan McDermott, Nathanael Gray, Daniel Haber, Patricia Greninger
2016-11-23

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy

Francesco Iorio, Gunnar W Klau, Ultan McDermott, Ilya Shmulevich
2016-09-08

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

Annalisa Mupo, Alena Pance, Yunfei Yang, Francesco Iorio, Konstantinos Tzelepis, David Kent, Niccolo Bolli, George S Vassiliou
2016-05-16

Multilevel models improve precision and speed of IC50 estimates

Howard Lightfoot, Francesco Iorio, Lorenzo Bombardelli

Human - wd:Q42877461

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