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Pharmacogenomics of GPCR Drug Targets.

author

David E. Gloriam

Mohan Madan Babu

published in: Cell

date of publication: 2017-12-08

language: English

main subject: G protein-coupled receptor, pharmacogenomics

Cites articles 68

Date

Title

Authors

2018-01-01

GPCRdb in 2018: adding GPCR structure models and ligands

David E. Gloriam, Christian Munk, Tsonko M Tsonkov, Stefan Mordalski, Kasper Skytte Harpsøe, Alexander S Hauser, Andrzej Bojarski
2017-10-06

Genetic variants affecting equivalent protein family positions reflect human diversity

J. Silvio Gutkind, Rob B Russell
2017-06-22

Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs
2017-05-24

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

Georgios Skiniotis, Brian Kobilka, Yan Zhang, Tong Sun Kobilka
2017-04-24

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Thomas Coudrat, Denise Wootten, Georgios Skiniotis, Brian Kobilka, Yan Zhang, David M Thal, Arthur Christopoulos, Alisa Glukhova
2017-02-23

Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling

Michel Bouvier, Olivier Lichtarge
2017-01-11

The role of interfacial lipids in stabilizing membrane protein oligomers

Kallol Gupta, Joseph A C Donlan, Weston B Struwe, David Drew, Phillip J. Stansfeld, Carol V. Robinson
2017-11-27

Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments.

Lili Milani, Volker M. Lauschke, Magnus Ingelman-Sundberg
2017-10-27

Trends in GPCR drug discovery: new agents, targets and indications

David E. Gloriam, Alexander S Hauser
2017-07-01

How Ligands Illuminate GPCR Molecular Pharmacology

Raymond C Stevens
2017-05-10

Selectivity determinants of GPCR-G-protein binding.

David E. Gloriam, Tilman Flock, Alexander S Hauser
2016-12-10

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

Harry Jubb, David B Ascher, Tom Blundell, Bernardo Ochoa-Montaño, Alicia P Higueruelo
2016-12-02

A comprehensive map of molecular drug targets

Anna Gaulton, John P. Overington, Rita Santos, Anne Hersey, Tudor I Oprea, Cristian G. Bologa
2016-10-05

denovo-db: a compendium of human de novo variants

Tychele N Turner, John Huddleston, Anna-Lisa Doebley, Deborah A Nickerson, Evan E. Eichler
2016-11-29

Open Targets: a platform for therapeutic target identification and validation

Henning Hermjakob, Claire O'Donovan, Gary Saunders, Jessica Vamathevan, Ewan Birney, Jeffrey C Barrett, Ian Dunham, Denise Carvalho Silva, Jennifer A Cham, Nikiforos Karamanis, Eliseo Papa, Miguel Pignatelli, Francis Rowland, Tony Burdett, Antonio Fabregat, Anna Gaulton, Cristina Y Gonzalez, Anne Hersey, Steven Jupe, Maria C Keays, María Paula Magariños, James Malone, Johanna McEntyre, Alfonso Munoz-Pomer Fuentes, Irene Papatheodorou, Helen Parkinson, Barbara Palka, Robert Petryszak, Naruemon Pratanwanich, Sirarat Sarntivijai, Konstantinos Sidiropoulos, Oliver Stegle, Amy Y Tang, Olga Vrousgou, Xavier Watkins, Maria-Jesus Martin
2016-10-25

Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function

Stefan Gahbauer, Rainer A Böckmann
2016-09-16

A Pluridimensional View of Biased Agonism

Claudio M Costa-Neto, Michel Bouvier
2016-08-17

Analysis of protein-coding genetic variation in 60,706 humans

Michael Boehnke, Sekar Kathiresan, Jaakko Tuomilehto, Markku Laakso, Karol Estrada, Aarno Palotie, Taru Tukiainen, Danish Saleheen, Gad Getz, Roberto Elosua, Adam Kiezun, Joanne Berghout, Pradeep Natarajan, James Ware, Hong-Hee Won, Douglas M. Ruderfer, Hugh Christian Watkins, Kaitlin E Samocha, Dongmei Yu, Eric Minikel, Christina M. Hultman, Mark Joseph Daly, Stacey Gabriel, Steven A McCarroll, Dermot McGovern, Patrick F. Sullivan, James G. Wilson, Pamela Sklar, John Danesh, Lorena Orozco, Benjamin M. Neale, Valentin Ruano Rubio, Eric Banks, Laura D. Gauthier, Namrata Gupta, Grace Tiao, Jeremiah M Scharf, Diego Ardissino, David Altshuler, Gina M Peloso, Konrad J. Karczewski, Timothy R Fennell, Anne H O'Donnell-Luria, David N. Cooper, Daniel P Howrigan, Mark McCarthy, Shaun M Purcell, Daniel G. MacArthur, Mark DePristo, Monkol Lek, Jason Flannick, Jack A Kosmicki, Menachem Fromer, Mitja Kurki, Ami Levy Moonshine, Khalid Shakir, Christine Stevens, Ruth McPherson, Ryan Poplin
2016-08-17

Patterns of genic intolerance of rare copy number variation in 59,898 human exomes

Mark Joseph Daly, Kaitlin E Samocha, Douglas M. Ruderfer
2016-08-15

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

Xavier Deupí, Franziska M Heydenreich, Tilman Flock, Michel Bouvier, Dmitry B Veprintsev, Gebhard Schertler
2016-07-28

Integrating structural and mutagenesis data to elucidate GPCR ligand binding

Christian Munk, Kasper Skytte Harpsøe, David E. Gloriam
2016-07-01

GPCRdb: the G protein-coupled receptor database - an introduction

Gert Vriend, Kasper Skytte Harpsøe, Vignir Isberg, Stefan Mordalski, Peter Kolb, Christian Munk, Andrzej Bojarski
2016-01-25

Genes with monoallelic expression contribute disproportionately to genetic diversity in humans

Sung Chun, Tobias L. Lenz
2016-10-25

Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson's disease

Vivian Altmann, Sidia M. Callegari-Jacques, Carlos Roberto Mello Rieder
2015-12-01

Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors
2015-11-17

dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins
2015-10-15

Pharmacogenomics in the clinic

Mary V Relling
2015-10-12

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Christopher Southan, Joanna L. Sharman, Elena Faccenda, Adam J Pawson, Steve Alexander, Anthony P Davenport, Michael Spedding, Jamie A. Davies
2015-10-01

A global reference for human genetic variation

Adam Auton, Shane McCarthy, Richard M. Durbin, 1000 Genomes Project
2015-08-12

Comparison of predicted and actual consequences of missense mutations

Anselm Enders, Chris Goodnow, Dan Andrews
2015-01-01

Monitoring G Protein Activation in Cells with BRET.
2015-07-30

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Vsevolod Katritch, Vadim Cherezov, Marc Messerschmidt, Sébastien Boutet, Uwe Weierstall, Anton Barty, Kay Diederichs, Karsten Melcher, Jörg Standfuss, Parker De Waal, Arne Möller, Martin Caffrey, Oleksandr Yefanov, Henry N. Chapman, Raymond C Stevens, Regina J Lee, Dianfan Li, Yuhui Dong, Bridget Carragher, Wayne L. Hubbell, Kuntal Pal, Minjia Tan, Shibom Basu, Nadia A. Zatsepin, Raimund Fromme, Chelsie E. Conrad, Vsevolod V. Gurevich, Thomas A White, Shatabdi Roy-Chowdhury, Christopher Kupitz, Cornelius Gati, Yanyong Kang, Andrii Ishchenko, Gye Won Han, Kelly M Suino-Powell, Dingjie Wang, Ingo Grotjohann, Meitian Wang, Petra Fromme, Haiguang Liu, Stella Lisova, Nicole Howe, Qingping Xu, Jiang Hualiang, Chenghai Zhang

Article - wd:Q47284414

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