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CTLA-4: a moving target in immunotherapy.

author

David M Sansom

Behzad Rowshanravan

Neil Halliday

published in: Blood

date of publication: 2017-11-08

language: English

main subject: immunotherapy

Cites articles 135

Date

Title

Authors

2017-02-03

Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations

Alan Kennedy, Neil Halliday, Waseem Qasim, Sophie Hambleton, Siobhan O Burns, David M Sansom, Olaf Neth, Austen Worth
2017-05-08

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

Udupi A Ramagopal, Steven C. Almo, Jeffrey B Bonanno
2016-01

Abatacept alleviates severe autoimmune symptoms in a patient carrying a de novo variant in CTLA-4

Hye-Eun Kim, Murim Choi, Jin Soo Moon, Gyeong Hoon Kang
2016-01-04

Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns

Deepali Malhotra, Thamotharampillai Dileepan, Brian T. Fife, Harry T. Orr, Marc K. Jenkins
2016-01-01

The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency

Markus G. Seidel, Nima Rezaei, Annette Schmitt-Graeff, Tomohiro Morio, Siobhan O Burns, Carsten Speckmann, Sophie Jung, Bodo Grimbacher
2016-02-02

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

Curtis Huttenhower, Asia Gobourne, Jedd D Wolchok, Eric G. Pamer
2016-04-11

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

Kajsa Wing, Shimon Sakaguchi
2016-04-28

Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice
2016-05-04

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

Alexander Eggermont, Caroline Robert, Jean-Charles Soria, Emilie Lanoy, Olivier Lambotte
2016-05-18

The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account
2016-05-01

CD28 Costimulation: From Mechanism to Therapy

Arthur Weiss
2016-10-03

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

James P. Allison
2016-11-01

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

Justin M. Balko, Elizabeth J. Phillips, Yaomin Xu, Christine E. Seidman, Dan Roden
2016-10-10

Efficient Culture of Human Naive and Memory B Cells for Use as APCs

Akiko Watanabe, Chen-Hao Yeh, Garnett Kelsoe
2016-12-28

Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire
2015-01-09

Confusing signals: recent progress in CTLA-4 biology

Lucy Walker, David M Sansom
2015-01-28

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells

Lucy Walker, David M Sansom
2015-02-10

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation

Gaurav Chopra
2015-02-10

The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells

Gustavo J. Martinez, Renata M S Pereira, Francesco Marangoni, Vigo Heissmeyer, K M Ansel, Anjana Rao, Shane Crotty
2015-03-26

Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: an open-label, single-arm, phase 2 study

Aldo Morra, Michele Maio, Luana Calabro', Riccardo Danielli, Diana Giannarelli
2015-03-17

Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor

Evangelia Petsalaki, Ruijun Tian, Anne-Claude Gingras, Arthur Weiss
2015-04-03

The future of immune checkpoint therapy

James P. Allison
2015-06-25

Pembrolizumab versus Ipilimumab in Advanced Melanoma

Caroline Robert, Adil Daud, Christian U Blank
2015-05-01

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes

Ning Jiang, Brian A Kidd, Sabina Müller, Michael E Birnbaum, Evan W Newell, Salvatore Valitutti, Stephen Quake
2015-05-31

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

Jean-Jacques Grob, Piotr Rutkowski, Pier Francesco Ferrucci, Michele Maio, Grant McArthur, Georgina V. Long, John Wagstaff, Lars Bastholt, Dirk Schadendorf, Paolo Antonio Ascierto, Mario Sznol, Jedd D Wolchok, F Stephen Hodi, James Larkin, Reinhard Dummer
2015-07-01

AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

Bernice Lo
2015-08-14

1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept

David M Sansom
2015-09-14

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Scott B Lovitch, Arlene Sharpe, Vijay Kuchroo, Gordon J. Freeman
2015-10-05

Integrated molecular analysis of adult T cell leukemia/lymphoma.

Masao Matsuoka, Teppei Shimamura, Ryohei Ishii, Tetsuichi Yoshizato, Kenichi Yoshida, Kotaro Shide, Kensei Tobinai, Akifumi Takaori-Kondo, Kengo Takeuchi, Satoru Miyano, Yuichi Shiraishi, Aiko Sato-Otsubo, Genta Nagae, Yasunobu Nagata, Kenichi Chiba, Hiroyuki Aburatani, Masashi Sanada, Seishi Ogawa, Tatsuhiro Shibata, Yasushi Totoki, Natsuko Hama, Hiromi Nakamura, Guangyong Ma, Jun-ichirou Yasunaga, Akira Kitanaka
2015-11-05

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Didier Raoult, Laurence Zitvogel, Nathalie Chaput, Sylvie Rusakiewicz, Guido Kroemer, Marie Vétizou, Romain Daillère, Nicolas Jacquelot, Paul-Louis Woerther, Vichnou Poirier-Colame, Caroline Flament, Alexander Eggermont, Takahiro Yamazaki, David P Enot, Caroline Robert, Sascha Cording, Gérard Eberl, Ivo G Boneca, Patricia Lepage, Mathias Chamaillard, Jérôme Nigou, Paule Opolon, Florent Ginhoux, Andreas Schlitzer, Maria P Roberti, Connie P Duong, Silvia C. Formenti, Jonathan Pitts Crick, Nadine Waldschmitt, Bertrand Routy, Antoine Roux, Sonia Becharef, Encouse Golden, Marion Bérard, Elisabeth Chachaty
2015-11-10

CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

Francois Legoux, Jong-Baeck Lim, Stanislav Dikiy, Tim Sparwasser, Sing Sing Way
2015-12-31

Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.

Qiang Gong

Article - wd:Q47424017

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