Brinton Seashore-Ludlow

occupation: researcher

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Articles 29

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Title

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2020-07-06

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

Thomas P Howard, Elaine M Oberlick, Matthew G Rees, Taylor E Arnoff, Minh-Tam Nguyen Pham, Andrew L Hong, Guillaume Kugener, Hsien-Chao Chou, Yiannis Drosos, Brinton Seashore-Ludlow, Andrew O Giacomelli, Hong Tiv, Cory M Johannessen, William C Hahn, Charles W Roberts, Stuart Schreiber
2019-01-01

Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines

Brinton Seashore-Ludlow
2019-10-30

Perspective on CETSA Literature: Toward More Quantitative Data Interpretation

Brinton Seashore-Ludlow, Thomas Lundbäck
2019-03-22

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

Tiina Öhman, Erika Gucciardo, Brinton Seashore-Ludlow, Markku Varjosalo, Kaisa Lehti
2018-02-12

In Situ Target Engagement Studies in Adherent Cells.

Hanna Axelsson, Magdalena Otrocka, Michaela Vallin, Thomas Lundbäck, Brinton Seashore-Ludlow
2018-03-05

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors

Jens Nielsen, Brinton Seashore-Ludlow, Johan Boström, Jonathan L Robinson, Oscar Krijgsman, Daniel Peeper, Mikael Altun, Mathias Uhlén, Gianluca Maddalo
2018-03-23

Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth

Magdalena Otrocka, Brinton Seashore-Ludlow, Matthew Kirkham
2018-11-29

Using High Content Imaging to Quantify Target Engagement in Adherent Cells

Brinton Seashore-Ludlow
2018-11-19

Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay

Brinton Seashore-Ludlow, Hanna Axelsson, Thomas Lundbäck
2017-08-14

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells

Stuart Schreiber, Brinton Seashore-Ludlow, Baishan Jiang, Daniel B Graham, Nathanael Gray, Ramnik J Xavier, Isabel Latorre
2017-07-12

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Pär Matsson, Brinton Seashore-Ludlow, Andrea Treyer, André Mateus, Thomas Lundbäck
2017-07-05

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Jill P. Mesirov, Brinton Seashore-Ludlow, John K Eaton, Vasanthi S Viswanathan, Srinivas R Viswanathan, Elisabeth M Roider, Zarko Boskovic, Kenichi Shimada, Dong Gao, Pablo Tamayo, William C Hahn, Jesse S Boehm, John G Doench, Daniel Haber, Brian M. Wolpin, Stuart Schreiber, Andrew J Aguirre, Jeffrey A Engelman, Paul A Clemons, Alykhan F Shamji
2017-12-15

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.

Andrew Leach, Jing Tang, Zia-Ur-Rehman Tanoli, Balaguru Ravikumar, Peddinti V. Gopalacharyulu, Elina Parri, Abhishekh Gupta, Anna-Lena Gustavsson, Brinton Seashore-Ludlow, Anne Hersey, John P. Overington, Gretchen Repasky, Krister Wennerberg, Tero Aittokallio
2017-10-21

A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth

Magdalena Otrocka, Brinton Seashore-Ludlow, Andras Simon, Matthew Kirkham
2016-07-13

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis

Selma Maric, Brinton Seashore-Ludlow, Anna-Lena Gustavsson, Thomas Lundbäck, Robert Schnell
2016-11-08

Validation and development of MTH1 inhibitors for treatment of cancer

Helge Gad, Rozbeh Jafari, Brinton Seashore-Ludlow, Alexey Chernobrovkin, Ann-Sofie Jemth, Torkild Visnes, Berglind O Einarsdottir, Olov A Wallner, Patrick Herr, Sean G Rudd, Anne M Filppula, Te-Chang Lee, Vassilis Gorgoulis, Janne Lehtiö, Roman Zubarev
2016-07-11

Early Perspective

Brinton Seashore-Ludlow, Thomas Lundbäck
2016-03-24

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

Ernest Fraenkel, Jill P. Mesirov, Brinton Seashore-Ludlow, Charles G Eberhart, Pablo Tamayo, Stuart Schreiber, Vasanthi S Viswanathan, Scott L Pomeroy, Tenley C. Archer, Paul A Clemons, Alykhan F Shamji
2015-12-14

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

Stuart Schreiber, Brinton Seashore-Ludlow, Benjamin Alexander, Philip Montgomery, Clary B Clish, Joshua A Bittker, Daniel Haber
2015-10-19

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

Brinton Seashore-Ludlow, Joshua A Bittker, Stuart Schreiber
2015-04-20

Discovery of a Small-Molecule Probe for V-ATPase Function

Szu-Yu Kuo, Brinton Seashore-Ludlow, Isabel Latorre, Ramnik J Xavier, Stuart Schreiber
2014-08-01

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality

Emma Shanks, Brinton Seashore-Ludlow, Eyal Gottlieb, Eytan Ruppin
2014-08-07

NAMPT is the cellular target of STF-31-like small-molecule probes

Brinton Seashore-Ludlow, Stuart Schreiber
2012-04-24

Enantioselective synthesis of anti-β-hydroxy-α-amido esters by asymmetric transfer hydrogenation in emulsions

Brinton Seashore-Ludlow
2012-07-17

Domino carbopalladation-cross-coupling for the synthesis of 3,3-disubstituted oxindoles

Brinton Seashore-Ludlow
2012-12-10

Asymmetric transfer hydrogenation coupled with dynamic kinetic resolution in water: synthesis of anti-β-hydroxy-α-amino acid derivatives

Brinton Seashore-Ludlow
2010-03-01

A general enantioselective route to the chamigrene natural product family

Brinton Seashore-Ludlow, Brian Stoltz, Robert H. Grubbs
2010-09-01

Domino carbopalladation-carbonylation: generating quaternary stereocenters while controlling beta-hydride elimination

Brinton Seashore-Ludlow
2010-10-21

Enantioselective synthesis of anti-β-hydroxy-α-amido esters via transfer hydrogenation

Brinton Seashore-Ludlow

Human - wd:Q47564206

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