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Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus.

författare

Andreas Hofmann

Rohan A. Davis

Robin B. Gasser

Sarah Preston

Anson V. Koehler

2000 -

Abdul Jabbar

publicerad i: Veterinary Parasitology

utgivningsår: 2017-07-11

huvudämne: naturprodukt, Stor magmask

Refererar artiklar 50

Datum

Titel

Författare

2016-02-22

Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).
2016-01-07

The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery

Rohan A. Davis
2016-01-27

Isoflavone formononetin from red propolis acts as a fungicide against Candida sp.

Eduardo Jesus Oliveira
2016-02-23

Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity
2015-05-14

Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90.
2015-12-08

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity

Hongchan An
2015-03-17

Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling
2015-03-05

Low cost whole-organism screening of compounds for anthelmintic activity

Abdul Jabbar, Anja Joachim, Pasi K. Korhonen, Andreas Hofmann, Sarah Preston, Cameron Nowell, David Piedrafita, Brendan R Ansell, Aaron R Jex, Robin B. Gasser, Jonathan B Baell
2015-09-10

Practical and low cost whole-organism motility assay: A step-by-step protocol.

Sarah Preston, Abdul Jabbar, Anja Joachim, Andreas Hofmann, Robin B. Gasser, Cameron Nowell
2015-04

The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families

Erich M Schwarz, Paul W. Sternberg
2015-12-01

A New Golden Age of Natural Products Drug Discovery
2015-05-27

Cracking the nodule worm code advances knowledge of parasite biology and biotechnology to tackle major diseases of livestock

Rahul Tyagi, Anja Joachim, Makedonka Mitreva, Shoba Ranganathan, Robin B. Gasser, Paul W. Sternberg
2015-01-01

Antibacterial activities of flavonoids: structure-activity relationship and mechanism
2014-02-01

AKT mediates actinomycin D-induced p53 expression
2014-03-20

Traditional plant-based remedies to control gastrointestinal disorders in livestock in the regions of Kamina and Kaniama (Katanga province, Democratic Republic of Congo).
2014-06-03

Synthesis and evaluation of antimalarial properties of novel 4-aminoquinoline hybrid compounds

Kathy Andrews, Gillian M Fisher
2014-12-21

The relationship between structure and in vitro antibacterial activity of selected isoflavones and their metabolites with special focus on antistaphylococcal effect of demethyltexasin

Johana Rondevaldová, Oldřich Lapčík
2014-10-15

Deguelin inhibits the migration and invasion of U-2 OS human osteosarcoma cells via the inhibition of matrix metalloproteinase-2/-9 in vitro

Jing-Gung Chung, Hsu-Feng Lu
2014-03

Genome of the human hookworm Necator americanus

Peter J. Hotez, Makedonka Mitreva, Patrick Minx, John Martin, Rahul Tyagi, Jason Mulvenna, Javier Sotillo, John M. Hawdon, Shoba Ranganathan, Robin B. Gasser, Paul W. Sternberg, Qi Wang, Bruce A Rosa, Wesley C Warren, Élida Mara Leite Rabelo
2013-09-25

Thiaplakortones A-D: antimalarial thiazine alkaloids from the Australian marine sponge Plakortis lita

Rohan A. Davis, Sandra Duffy, Vicky M. Avery, Ronald J. Quinn, Sabine Fletcher
2013-02-01

New advancement in anthelmintic drugs in veterinary medicine
2013-08-01

A Concise Enantioselective Synthesis and Cytotoxic Evaluation of the Anticancer Rotenoid Deguelin Enabled by a Tandem Knoevenagel/Conjugate Addition/Decarboxylation Sequence

Karl A Scheidt
2013

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

Matthew Berriman, Nancy Holroyd, Aude Gilabert, Gary Saunders, Martin Hunt, Isheng J Tsai, Adam J Reid, Collette Britton, James A. Cotton, Eileen Devaney, James David Wasmuth, Roz Laing, Taisei Kikuchi, Helen Beasley, Robin N Beech, Adrian J Wolstenholme
2013-06-10

Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells
2013-08-28

The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus

Erich M Schwarz, Pasi K. Korhonen, Neil D Young, Andreas Hofmann, Alex Loukas, C. Titus Brown, Abdul Jabbar, Robin B. Gasser, Aaron R Jex, Peter R. Boag, Xing-Quan Zhu, Paul W. Sternberg, Jason Pell, Bronwyn E Campbell, T. Ryan Gregory, Ross S Hall, Alinda Mondal
2013-01-21

A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer
2013-08-07

Amelioration of an undesired action of deguelin
2012-09-17

Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model
2012-12-07

Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis
2012-11-16

Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis

Karren Beattie, Rohan A. Davis, Claire Levrier, Frédéric Martin, Anthony R Carroll, Vanida Choomuenwai
2012

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat
2011-10-08

Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions

Nicolas Winssinger

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