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Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

লেখক

David G Mutch

Luciano Cascione

Matthias Peter

Levi A Garraway

Holger Moch

এতে প্রকাশিত: Nature Medicine

তারিখে প্রকাশিত: 2017-08-14

ভাষা: ইংরেজি ভাষা

Cites articles 45

তারিখ

শিরোনাম

লেখকগণ

2017-03-01

SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling

Christopher E. Barbieri, Dong Gao, Mark Rubin, Arul Chinnaiyan, Andrea Sboner, Verena Sailer, Michael Augello
2016-05-24

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer

Qing Zhong, Tiannan Guo, Levi A Garraway, Ruedi Aebersold, Myles Brown
2016-01-06

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

Daniel G. Stover, Housheng Hansen He, Myles Brown, রিচার্ড এ ইয়াং, Clifford A. Meyer, Kornelia Polyak, Eric Winer
2016-06-05

Targeting BET bromodomain proteins in solid tumors
2016-06-27

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis

Amaro Taylor-Weiner, Gad Getz, Camilla Krakstad, Frederik Holst, Mara Rosenberg, Jone Trovik, Rameen Beroukhim, Eran Hodis, Andrew D Cherniack, Helga Salvesen, Olav Karsten Vintermyr
2016-02-29

Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

Jay Shendure, Nikolaus Schultz, Robert L Vessella
2016-07-20

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer

Jonathan Chernoff
2016-01-01

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

Jüri Reimand, Dana Pe'er, Gary D. Bader
2016-07-18

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms

Joseph Schlessinger
2016-03-31

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

Kurt M Reichermeier, Florian Stengel, Raymond J. Deshaies, Alexander Leitner, Ruedi Aebersold, Martin Winkler
2015-09-03

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

Andrea Lunardi, Zhen Li, Pier Paolo Pandolfi
2015-09-02

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.

Jun Yan
2015-01-01

Targeting BET bromodomains for cancer treatment

Amaury E Fernández-Montalván
2015-02-18

Functions of BET proteins in erythroid gene expression

Aaron Stonestrom, Stephan Kadauke, Amy E Campbell, Ross Hardison
2015-07-03

Beating the odds: BETs in disease

Panagis Filippakopoulos
2015-01-26

The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs

Paola Bonetti, Luciano Cascione, Emanuele Zucca, Francesco Bertoni, Chiara Tarantelli, Ivo Kwee, Elena Bernasconi, Anastasios Stathis, Georg Stüssi, Maurilio Ponzoni, Afua Adjeiwaa Mensah, Michela Boi, Monica Testoni, Esteban Cvitkovic
2015-11-01

The Molecular Taxonomy of Primary Prostate Cancer
2015-05-21

Integrative clinical genomics of advanced prostate cancer

Carrie Sougnez, Olivier Elemento, Susana Miranda, Heidi Dvinge, Jeremy C Durack, রবার্ট কে ব্র্যাডলি, Dana E Rathkopf, Francesca Demichelis, মাইকেল জে. মরিস, Gerhardt Attard, ডেভিড সি স্মিথ, Kathleen A. Cooney, Mark Rubin, Philip W. Kantoff, Massimo Loda, Nikolaus Schultz, Mary-Ellen Taplin, Levi A Garraway, Kenneth J. Pienta, Arul Chinnaiyan, Johann Sebastian de Bono, Andrea Sboner, Himisha Beltran, Juan Miguel Mosquera, Scott A Tomlins, Xuhong Cao, Victor Reuter, Martin R. Delany, Eliezer Van Allen, Robert J Lonigro, Donald Bruce Montgomery, Wassim Abida, Lakshmi P Kunju, Felix Y Feng, Jianjiong Gao, Lawrence D True, Zafeiris Zafeiriou, David M Nanus, Scott T Tagawa, Jake Vinson, Pankaj Vats, Maha Hussain, Christine Brennan, Stephen B Solomon, Anuradha Gopalan, Rosina T Lis, Michaela Bowden, Stephen P Balk, Glenn Gaviola, Manaswi Gupta, Elahe A Mostaghel, Heather H Cheng, Hyojeong Mulcahy, Stephen R Plymate, Roberta Ferraldeschi, Penny Flohr, Nina Tunariu, Joaquin Mateo, Raquel Perez-Lopez, Marc Schiffman, Alexandros Sigaras, Kenneth Eng, Elisabeth I Heath
2014-01-01

Translating genomics for precision cancer medicine
2014-01-01

SPOP mutations in prostate cancer across demographically diverse patient cohorts

Mark Rubin, Igor Dolgalev, Katja Fall, Francesca Demichelis, Christopher E. Barbieri, Andrea Sboner, Mirjam Blattner, Ashutosh Tewari, Juan Miguel Mosquera, Ove Andrén, Holger Moch
2014-09-19

Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes

Samuel V Angiuoli, Siân Jones, Victor Velculescu, Luis Alberto Diaz Jr, Laura D Wood, Mark Sausen, Lisa Kann, Christine L McCord, Manish R Shukla
2014-10-02

Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

Gilbert G Privé, Mark Rubin, Levi A Garraway, Holger Moch
2014-10-01

Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer

Shrijal S Shah, Sue Anne Chew
2014-06-05

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

Christopher R. Vakoc
2014-04-23

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Irfan Asangani, Zhaohui Steve Qin
2013-05-02

Integrated genomic characterization of endometrial carcinoma

Elaine Mardis, Cyriac Kandoth, Nikolaus Schultz, Andrew D Cherniack, গর্ডন বি মিলস
2013-04-04

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

Christopher E. Barbieri, Francesca Demichelis, Mark Rubin, Bert W. O'Malley, Mirjam Blattner, Pengbo Zhou
2013-09-19

Large-scale identification of ubiquitination sites by mass spectrometry
2013-04-24

The estrogen-regulated anterior gradient 2 (AGR2) protein in breast cancer: a potential drug target and biomarker
2013-06-09

Integrated proteomic analysis of post-translational modifications by serial enrichment

Karl R. Clauser, D R Mani
2012-06

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

এরিক ল্যান্ডার, Candace Guiducci, Kristian Cibulskis, Gad Getz, Daniel Auclair, Wendy Winckler, Gordon Saksena, Nicolas Stransky, Douglas Voet, Kristin Ardlie, Elizabeth Nickerson, Jean-Philippe Theurillat, Petar Stojanov, Gunther Boysen, Eliezer Van Allen, Christopher E. Barbieri, Francesca Demichelis, Mark Rubin, Philip W. Kantoff, Matthew Meyerson, Stacey Gabriel, Levi A Garraway, Todd Golub, Andrey Sivachenko, Sung-Suk Chae, Sylvan C Baca, Mirjam Blattner, Robert Onofrio, Naoki Kitabayashi, Terry Vuong, Scott L Carter, Wasay M Hussain, Ashutosh Tewari, Juan Miguel Mosquera, Colm Morrissey, Holger Moch, Michelle Redman-MacLaren, Alex H Ramos
2012-10-28

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

Matthieu Le Gallo, Nigel J O'Neil, James C Mullikin

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