Nicholas M Kanaan

opleiding gevolgd aan: Rush University Medical Center

beroep: onderzoeker

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Artikels 40

Date

Titel

Auteurs

2020-06-04

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

Nicholas M Kanaan, Benjamin Combs
2019-12-01

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

Jeanna M Wheeler, Pamela McMillan, Timothy J Strovas, Nicole F Liachko, Alexandre Amlie-Wolf, Rebecca L Kow, Patricia Szot, Linda Robinson, Chris Guthrie, Aleen Saxton, Nicholas M Kanaan, Murray Raskind, Elaine Peskind, John Q. Trojanowski, Li-San Wang, C Dirk Keene, Gerard D Schellenberg, Brian C Kraemer
2018-01-25

Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease.

Nicholas M Kanaan, Elliott J Mufson, Scott E. Counts
2018-03-17

Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization

Nicholas M Kanaan, Masamichi Ikawa
2018-03-07

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.

Kathryn L Lunetta, Tsuneya Ikezu, Ella Zeldich, Nicholas M Kanaan, Lindsay A Farrer, Carmela R Abraham
2018-05-01

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Nicholas M Kanaan, Megan F Duffy, Joseph R Patterson, Kelvin C Luk, D Luke Fischer, Nour K Majbour, Caryl E Sortwell
2018-05-29

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Kelvin C Luk, Nicholas M Kanaan, Megan F Duffy, Joseph R Patterson, D Luke Fischer, Nour K Majbour, Caryl E Sortwell
2018-03-01

Tau Kinetics in Neurons and the Human Central Nervous System

Bruce W Patterson, Brian A Gordon, Nicholas M Kanaan, Celeste M Karch, Tammie L. Benzinger, Randall J Bateman, Kwasi G. Mawuenyega, Jennifer Jockel-Balsarotti, Matthew J Crisp, Tom P Kasten, Kristopher M Kirmess, Kevin Yarasheski, Alaina Baker-Nigh
2018-05-01

Tau Kinetics in Neurons and the Human Central Nervous System

Brian A Gordon, Celeste M Karch, Bruce W Patterson, Tammie L. Benzinger, Randall J Bateman, Nicholas M Kanaan, Kwasi G. Mawuenyega, Jennifer Jockel-Balsarotti, Matthew J Crisp, Tom P Kasten, Kristopher M Kirmess, Kevin Yarasheski, Alaina Baker-Nigh
2017-07-21

Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats

Andrew Kneynsberg, Nicholas M Kanaan
2017-05-18

Aging and Parkinson's disease: Different sides of the same coin?

Nicholas M Kanaan, Jeffrey H Kordower
2017-06-21

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

Nicholas M Kanaan, William W Hauswirth, Mavis Agbandje-McKenna
2017-04-14

Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies

Nicholas M Kanaan, Benjamin Combs
2017-10-17

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

Kyle Christensen, Andrew Kneynsberg, Nicholas M Kanaan
2017-11-20

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.

Nicholas M Kanaan, Benjamin Wolozin, Antonio Ferragud, Cheng Zhang, Yorghos Tripodis, Tsuneya Ikezu, Hu Li, Jennifer Luebke
2017-07-14

Production of recombinant tau oligomers in vitro.

Nicholas M Kanaan
2016-06-15

Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures

Andrew Kneynsberg, Nicholas M Kanaan
2016-01-01

Gene Therapy Models of Alzheimer's Disease and Other Dementias

Andrew Kneynsberg, Nicholas M Kanaan
2016-03-08

Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease

Stephen D Ginsberg, Nicholas M Kanaan, Elliott J Mufson, Scott E. Counts
2016-10-10

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons

Nicholas M Kanaan, Akitsu Hotta, John Q. Trojanowski
2016-10-21

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline

Nicholas M Kanaan
2016-11-17

Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation

Nicholas M Kanaan
2016-01-01

Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study

Nicholas M Kanaan, Ann McKee, Elliott J Mufson, Sylvia E. Perez
2016-08-16

Pioglitazone prevents tau oligomerization

Tadanori Hamano, Nicholas M Kanaan, Masamichi Ikawa, Norimichi Shirafuji, Asako Ueno, Akiko Matsunaga, Osamu Yamamura, Masaru Kuriyama, Yasunari Nakamoto
2016-06-30

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport

Nicholas M Kanaan, Scott E. Counts
2016-05-31

Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies

Benjamin Combs, Nicholas M Kanaan
2016-01-20

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

Einar M Sigurdsson, Mauro Fà, Daniela Puzzo, Roberto Piacentini, M A Baltrons, Hanna Berman, Walter Gulisano, Luciano D'Adamio, Luciano D'Adamio, Claudio Grassi, Nicholas M Kanaan, Ottavio Arancio
2016-07-29

Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition

Nicholas M Kanaan
2015-06-17

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Kelvin C Luk, Nicholas M Kanaan, John Q. Trojanowski, Kathy Steece-Collier
2015-03-20

A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures

Andrew Kneynsberg, Nicholas M Kanaan
2015-05-20

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes

Nicholas M Kanaan, Kathy Steece-Collier
2014-10-13

Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain

Nicholas M Kanaan, Kathy Steece-Collier

Human - wd:Q51765020

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