David Gadsby

1947 - 2019

educated at: University College London, Trinity College

award received: Fellow of the Royal Society, Fellow of the American Association for the Advancement of Science

David Christopher Gadsby FRS (26 March 1947 – 3 March 2019) was a British physiologist, and Patrick A. Gerschel Family Professor Emeritus at The Rockefeller University. He was best known for his studies on the mechanisms by which ions move across cell membranes. He earned a BSc in 1969 and MSc in 1973, from Trinity College, Cambridge, and Ph.D. in 1978 from University College London. He studied with Paul F. Cranefield. He won the Kenneth S. Cole Award of the Biophysical Society in 1995. He was elected Fellow of the Royal Society in 2005. Source: Wikipedia (en)

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Articles 54

Date

Title

Authors

2019-01-01

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL

László Csanády, Paola Vergani, David Gadsby
2017-05-04

Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump

Natascia Vedovato, Thomas Holm, Kamran Khodakhah, Karin Lykke-Hartmann, David Gadsby
2017-03-01

Molecular Structure of the Human CFTR Ion Channel

László Csanády, David Gadsby
2015-04-01

Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels

David Gadsby
2014-04-01

Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps

Natascia Vedovato, David Gadsby
2012-02-14

The dynamic relationships between the three events that release individual Na⁺ ions from the Na⁺/K⁺-ATPase

David Gadsby
2012-01

Energetics of the Reactions Controlling the Deeply Occluded State of the Na+/K+ Pump

David Gadsby
2011-12-05

Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid

Daniel Basilio, David Gadsby
2011-01-01

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation.

László Csanády, Paola Vergani, David Gadsby
2010-06-14

The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions

Natascia Vedovato, David Gadsby
2009-12-04

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations

László Csanády, Paola Vergani, David Gadsby
2009-01-01

Review. Peering into an ATPase ion pump with single-channel recordings

Nicolás Reyes, David Gadsby
2009-04-02

Ion channels versus ion pumps: the principal difference, in principle

David Gadsby
2009-11-10

Visualizing the mapped ion pathway through the Na,K-ATPase pump

David Gadsby
2009-01-01

Introduction. The blurred boundary between channels and transporters

Frances Ashcroft, David Gadsby
2008-10-08

The ion pathway through the opened Na(+),K(+)-ATPase pump

David Gadsby
2007-06-11

Sodium flux ratio in Na/K pump-channels opened by palytoxin

David Gadsby
2007-12-01

Structural biology: ion pumps made crystal clear

David Gadsby
2006-03-23

The ABC protein turned chloride channel whose failure causes cystic fibrosis

László Csanády, Paola Vergani, David Gadsby
2006-08-07

Ouabain affinity determining residues lie close to the Na/K pump ion pathway

David Gadsby
2006-10-16

Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle

László Csanády, Angus C. Nairn, David Gadsby
2006-10-12

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

Angus C. Nairn, Paola Vergani, David Gadsby
2006-09-01

Ion permeation through the Na+,K+-ATPase

Nicolás Reyes, David Gadsby
2005-01-18

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

László Csanády, Angus C. Nairn, David Gadsby
2005-02-01

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

Paola Vergani, Angus C. Nairn, David Gadsby
2004-12-13

Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain

László Csanády, Angus C. Nairn, David Gadsby
2004-03-15

Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands

David Gadsby
2004-02-01

Ion transport: spot the difference.

David Gadsby
2003-04-01

Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na/K pumps

David Gadsby
2003-01-01

On the mechanism of MgATP-dependent gating of CFTR Cl- channels

Paola Vergani, Angus C. Nairn, David Gadsby
2003-09-01

Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating

Paola Vergani, Angus C. Nairn, David Gadsby
2003-07-01

Paul F. Cranefield, M.D., Ph.D. April 28, 1925 to May 31, 2003.

David Gadsby

Human - wd:Q5233969

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