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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

auteur·ice

Joseph Goldstein

1940 -

publié dans: Journal of Biological Chemistry

date de publication: 1999-10-01

langue: anglais

sujet principal: lignée cellulaire

Articles cités 31

Date

Titre

Auteur·ices

1999-02-01

A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter
1999-04-01

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis
1999-08-06

Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins
1998-03-01

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

Juro Sakai, Axel Nohturfft
1998-07-01

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

Joseph Goldstein
1998-10-01

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro
1998-10-01

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

Juro Sakai
1998-10-01

Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

Joseph Goldstein
1998-10-02

Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
1998-10-01

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N

Axel Nohturfft
1997-05-02

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Joseph Goldstein
1997-08-08

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

Joseph Goldstein
1997-07-01

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.
1997-05-01

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

Joseph Goldstein
1997-12-01

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
1996-11-01

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

Axel Nohturfft
1996-11-01

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines

Axel Nohturfft
1996-04-26

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

Joseph Goldstein
1996-06-28

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
1996-08-01

Intracellular trafficking of cholesterol monitored with a cyclodextrin
1995-05-01

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

Joseph Goldstein
1994-09-01

The ancient regulatory-protein family of WD-repeat proteins

Carl Schmidt
1994-05-01

Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression

Ta-Yuan Chang
1994-04-08

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Joseph Goldstein
1991-07-26

cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1,cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

David W. Russell
1989-09-01

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells

Joseph Goldstein
1983-01-01

Receptor-mediated endocytosis of low-density lipoprotein in cultured cells,19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

Joseph Goldstein
1982-10-01

Revertants of a Chinese hamster ovary cell mutant resistant to suppression by an analogue of cholesterol: isolation and partial biochemical characterization
1982-01-01

A catalogue of splice junction sequences

Stephen M. Mount
1979

Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells,Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cells

Joseph Goldstein, Henry Pownall
1951-11-01

Protein measurement with the Folin phenol reagent

Oliver Lowry, Nira Rosebrough, Lewis Farr, Rose Randall

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