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[Structure of the Smoothened receptor].

author

Lucile Hoch

Didier Rognan

1962 -

published in: médecine/sciences

date of publication: 2013-10-18

language: French

Cites articles 29

Date

Title

Authors

2013-05-16

Structure of the human smoothened receptor bound to an antitumour agent

Vsevolod Katritch, Vadim Cherezov, Huixian Wu, Xi-Ping Huang, Raymond C Stevens, Bryan L. Roth, Fai Yiu Siu, Gye Won Han
2013-01-08

Hedgehog pathway inhibitors: a patent review (2009--present).
2013-05-03

Structural Basis for Molecular Recognition at Serotonin Receptors

Vsevolod Katritch, Daniel Wacker, Vadim Cherezov, Karsten Melcher, Huixian Wu, Fang Bai, Raymond C Stevens, Jiang Hualiang, John D McCorvy, Bryan L. Roth, Gye Won Han, Eyal Vardy, Chenghai Zhang
2013-05-03

Structural Features for Functional Selectivity at Serotonin Receptors

Vsevolod Katritch, Daniel Wacker, Vadim Cherezov, Raymond C Stevens, John D McCorvy, Bryan L. Roth, Fai Yiu Siu, Gye Won Han, Eyal Vardy
2013-02-01

Decoding the phosphorylation code in Hedgehog signal transduction
2013-03-26

Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction
2013-02-28

Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened

Fabrizio Manetti, Lucile Hoch, Elisabeth Traiffort, Nicolas Girard
2012-03-09

Hedgehog pathway as a drug target: Smoothened inhibitors in development
2012-10-12

[Subtypes of medulloblastomas: distinct cellular origins].

Franck Bourdeaut
2012-08-19

Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors

Maikel P Peppelenbosch
2012-10-01

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

Patrice D. Cani, Fritz Aberger, Josef M Penninger, Gerhard Wiche, Lilli Winter, Claude Knauf, Robert S. Lee-Young, Sean Mcgee
2012-08-01

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.

Jérôme Avouac, Georg Schett
2012-01-08

Oxysterols are allosteric activators of the oncoprotein Smoothened

Douglas F Covey
2011-11-30

Shh signal and its functional roles in normal and diseased brain

Elisabeth Traiffort
2011-12-09

Hedgehog trafficking, cilia and brain functions

Julien Ferent, Elisabeth Traiffort
2011-05-26

The Hedgehog's tale: developing strategies for targeting cancer

Tom Curran
2011-03

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist
2010-09-01

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma

John Monahan
2010-12-01

International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors

Gunnar Schulte
2010-02-23

Stability study of the human G-protein coupled receptor, Smoothened

Olivier Joubert
2010-12-01

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

Stephen E. Gould, Zora Modrusan
2010-04-13

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

Tannishtha Reya
2009-05-13

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

Suzie J Scales
2009-10-23

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Stephen E. Gould
2009-11-15

Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
2007-10-24

Hedgehog regulates smoothened activity by inducing a conformational switch

Chao Tong
2006-03-10

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
2006-08-22

Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
2004-11-01

[New insights into the pharmacology of the extracellular calcium sensing receptor].

Article - wd:Q54713457

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