George Aghajanian

1932 - 2023

country of citizenship: United States of America

educated at: Yale School of Medicine, Cornell University

occupation: neuroscientist, neuropharmacologist

award received: Scheele Award, Daniel H. Efron Research Award

George K. Aghajanian (April 14, 1932 – July 4, 2023) was an American psychiatrist who was Emeritus Foundations Fund Professor at the Yale School of Medicine, New Haven, Connecticut, in the Department of Psychiatry. He was a pioneer in the area of neuropharmacology. He also served as a member of the NARSAD Scientific Advisory Board. Source: Wikipedia (en)

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Articles 34

Date

Title

Authors

2020-07-22

Torgny Svensson, M.D., Ph.D. (1945-2020)

John H Krystal, Aleksander A. Mathé, George Aghajanian
2016-03-01

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

John H Krystal, Ronald Duman, George Aghajanian, Gerard Sanacora
2016-09-16

GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine

Brendan Hare, Ronald Duman, George Aghajanian, Rong-Jian Liu, Catharine Duman
2015-06-08

Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions

Ralph J. DiLeone, Ronald Duman, George Aghajanian, Eric S Wohleb
2015-03-11

Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses

Sophie Dutheil, Kristie T. Ota, Ronald Duman, George Aghajanian, Rong-Jian Liu
2014-01-19

Medial prefrontal D1 dopamine neurons control food intake

Karl Deisseroth, Carol A Gianessi, Maysa Sarhan, Ralph J. DiLeone
2014-04-13

REDD1 is essential for stress-induced synaptic loss and depressive behavior

Sophie Dutheil, Masaaki Iwata, Ralph J. DiLeone, David A. Lewis, Kristie T. Ota
2014-01-01

Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β.

Ronald Duman, George Aghajanian
2013-06-14

Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses

Andrea Navarria, Ronald Duman, Mounira Banasr, George Aghajanian, Rong-Jian Liu, Bhavya Voleti, Gerard Sanacora, Nanxin Li
2013-05-17

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine

Ronald Duman, George Aghajanian, Rong-Jian Liu
2012-10-01

Synaptic dysfunction in depression: potential therapeutic targets

Ronald Duman, George Aghajanian
2011-10-29

Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex

Ronald Duman, George Aghajanian, Rong-Jian Liu
2011-02-03

Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure

Ronald Duman, Mounira Banasr, George Aghajanian, Rong-Jian Liu
2011-09-02

Signaling pathways underlying the rapid antidepressant actions of ketamine

Ronald Duman, George Aghajanian, Rong-Jian Liu
2010-06-01

Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone

Ralph J. DiLeone, George Aghajanian, Rong-Jian Liu
2010-08-01

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

Masaaki Iwata, Ronald Duman, Mounira Banasr, George Aghajanian, Rong-Jian Liu, Jason M Dwyer
2009-02-25

Modeling "psychosis" in vitro by inducing disordered neuronal network activity in cortical brain slices

George Aghajanian
2008-01-08

Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy

George Aghajanian, Rong-Jian Liu
2008-01-28

Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies

Eric J. Nestler, George Aghajanian
2007-07-26

Schizophrenia, hypocretin (orexin), and the thalamocortical activating system

Evelyn K. Lambe
2006-03-01

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

Evelyn K. Lambe, Rudolf Jaenisch
2006-07-01

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice

Evelyn K. Lambe, Jean-Pierre Hornung, Shigeyoshi Itohara, William T Dauer, Stuart C Sealfon, Etienne Sibille, René Hen, George Aghajanian
2006-04-01

Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors

Eric J. Nestler, Rachael L. Neve, George Aghajanian, Rong-Jian Liu
2005-02-01

Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases

Evelyn K. Lambe, George Aghajanian, Rong-Jian Liu
2005-05-01

Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat

Evelyn K. Lambe, George Aghajanian
2005-11-02

Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors

Evelyn K. Lambe, George Aghajanian
2003-02-01

Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex

Evelyn K. Lambe, Marina Picciotto, George Aghajanian
2003-03-01

Regulation of RGS proteins by chronic morphine in rat locus coeruleus

Eric J. Nestler, George Aghajanian, Rong-Jian Liu
2003-09-01

Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice.

Evelyn K. Lambe, George Aghajanian
2003-11-24

Patricia Goldman-Rakic, 1937–2003

George Aghajanian
2002-11-01

Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions

George Aghajanian, Rong-Jian Liu
2002-05-01

Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus

George Aghajanian, Rong-Jian Liu

Human - wd:Q5536095

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