Alexander L Breeze

учебное заведение: Имперский колледж Лондона

род занятий: исследователь

официальный сайт: www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=ABR

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Статьи 29

Дата

Заголовок

Авторы

2021-06-30

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Katarzyna Haza, Heather Martin, Christian Tiede, Anna A Tang, Thomas L Adams, Chi H Trinh, Alexander L Breeze, Thomas A Edwards, Darren C. Tomlinson
2019-02-01

The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs

Alexander L Breeze, Alexander Cameron, Nilson Zanchin, Fabio Henrique Dos Santos Rodrigues, Martin Walko
2018-02-22

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Brendan Farrell, Domenico Sanfelice, Glenn R Masson, Дмитрий Иванович Свергун, Alexander L Breeze, Tom D Bunney
2018-03-26

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074.

Domenico Sanfelice, Brendan Farrell, Alexander L Breeze
2018-05-11

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

Miquel Pons, João M C Teixeira, Simon P Skinner, Miguel Arbesú, Alexander L Breeze
2018-12-17

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

Brendan Farrell, Alexander L Breeze
2017-09-06

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs.

Harald Schwalbe, Lars T Kuhn, Alexander L Breeze
2016-03-23

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

Adam Nelson, Andrew J. Wilson, Stuart L. Warriner, Thomas A Edwards, George M. Burslem, Alexander L Breeze
2016-03-24

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

Adam Nelson, Andrew J. Wilson, Stuart L. Warriner, Thomas A Edwards, George M. Burslem, Alexander L Breeze
2016-03-16

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.

Christine Orengo, Margaret A Knowles, Andrew Potterton, Alexander L Breeze
2015-02-26

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation

Alexander L Breeze, Ross C Overman
2015-10

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies

Adam Nelson, Darren C. Tomlinson, Andrew J. Wilson, Stuart L. Warriner, Thomas A Edwards, Christian Tiede, George M. Burslem, Alexander L Breeze
2015-11-12

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

Alexander P. Golovanov, Alexander L Breeze
2015-02-18

Target-based whole-cell screening by ¹H NMR spectroscopy

Alexander L Breeze
2015-07-23

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

Jonathan J Phillips, Alexander L Breeze
2014-12-02

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4

Alexander L Breeze, Ross C Overman
2014-04-29

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction

Adam Nelson, Andrew J. Wilson, Stuart L. Warriner, Thomas A Edwards, George M. Burslem, Alexander L Breeze
2014-01-23

Real-time monitoring of New Delhi metallo-β-lactamase activity in living bacterial cells by 1H NMR spectroscopy

Alexander L Breeze
2013-12-06

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

Alexander L Breeze
2012-03-26

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

Alexander L Breeze, Alessandro T. Caputo, Jonathan Wingfield
2012-08-12

¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH

Alexander L Breeze, Alexander P. Golovanov
2011-02-16

Fragment screening to predict druggability (ligandability) and lead discovery success

Alexander L Breeze
2007-01-01

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

Niklas Blomberg, Adam B Shapiro, Alexander L Breeze, Jeremy Burrows
2005-05-01

Structure-based design of protein tyrosine phosphatase-1B inhibitors

Alexander L Breeze
1996-07-01

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase

Alexander L Breeze
1994-06-01

Secondary structure and backbone dynamics of human granulocyte colony-stimulating factor in solution

Alexander L Breeze
1991-01-01

Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics

Alexander L Breeze
1989-01-01

Interactions between discrete neuronal membrane binding sites for the putative K+-channel ligands beta-bungarotoxin, dendrotoxin and mast-cell-degranulating peptide

Alexander L Breeze
1984-01-01

Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release

Alexander L Breeze

Human - wd:Q60960201

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