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Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder

författare

Héléna Gaspar

1988 -

Christopher Huebel

Christel M Middeldorp

Eske M Derks

1975 -

Gerome Breen

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC)

Zachary F Gerring

publicerad i: Translational Psychiatry

utgivningsår: 2019-03-15

språk: engelska

huvudämne: depression, hypotes

Refererar artiklar 47

Datum

Titel

Författare

2019-07-01

Drug Targetor: a web interface to investigate the human druggome for over 500 phenotypes

Héléna Gaspar, Christopher Huebel, Gerome Breen
2018-04-26

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.,Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Naomi R. Wray, Jakob Grove, Hamdi Mbarek, Eco de Geus, Patrick F Sullivan, André Uitterlinden, Glyn Lewis, Na Cai, Paola Giusti-Rodríguez, Margarita Rivera, Alexander Viktorin, Rick Jansen, Eske M Derks, Lili Milani, Daniel J. Smith, Thomas F. Hansen, Henriette N Buttenschøn, Rudolf Uher, Danielle Posthuma, Michael C O'Donovan, Cathryn Lewis, Sven Cichon, Gerome Breen, Ian Deary, Katherine E. Tansey, David A Hinds, Dale R Nyholt, Bradley T Webb, Julia Kraft, Stefan Kloiber, Jian Yang, Baptiste Couvy-Duchesne, Sara Mostafavi, Penelope A. Lind, Esben Agerbo, Andrew M. McIntosh, Jonathan Mill, Andres Metspalu, Tõnu Esko, Ian B Hickie, Isaac Kohane, Enrico Domenici, Christel M Middeldorp, Gregory E. Crawford, Franziska Degenhardt, Engilbert Sigurdsson, Valentina Escott-Price, Thomas Werge, Merete Nordentoft, Peter M Visscher, Hreinn Stefansson, Marcella Rietschel, Gonneke Willemsen, Dorret I. Boomsma, Kenneth Kendler, Grant W. Montgomery, Jonathan Marchini, Kári Stefánsson, Myrna M. Weissman, Jouke-Jan Hottenga, Andrew C. Heath, Zoltán Kutalik, Bertram Müller-Myhsok, Evelin Mihailov, Brenda Penninx, Henning Tiemeier, Jordan W Smoller, Preben Bo Mortensen, Alexander Teumer, Peter McGuffin, Fulai Jin, Erik Pettersson, Per Qvist, Tracy M Air, Wouter J Peyrot, Nese Direk, Donald J. MacIntyre, Jesper Krogh, Eilis Hannon, Maciej Trzaskowski, Scott D Gordon, Jane H Christensen, Enrique Castelao, Divya Mehta, Jonas Bybjerg-Grauholm, Toni-Kim Clarke, Lucía Colodro-Conde, Michel G. Nivard, Stephan Ripke, Nancy Pedersen, Martin Preisig, Anders Børglum, Patrik K E Magnusson, Julien Bryois, Volker Arolt, Conor Dolan, Abdel Abdellaoui, Yuri Milaneschi, Pippa A Thomson, Per Hoffmann, Thorgeir E. Thorgeirsson, Stephanie H Witt, Nick Martin, Markus M Nöthen, Thomas G. Schulze, Bernhard Baune, Douglas F Levinson, Shaun M Purcell, James B Potash, Hans J Grabe, Roy H Perlis, Johannes H Smit, Enda M Byrne, Mark J Adams, Till F.M. Andlauer, Tim B. Bigdeli, Andreas J Forstner, Fernando S Goes, David M Hougaard, Patrick Mcgrath, Muredach P. Reilly, Steven P Hamilton, Ashley R Winslow, Brien P. Riley, Stacy Steinberg, Nick Craddock, Susanne Lucae, Elisabeth Binder, Stefan Herms, Stanley I Shyn, Jens Treutlein, Manuel Mattheisen, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T F Beekman, Erin Dunn, Thalia C Eley, Hilary K Finucane, Lynsey S Hall, Christine Søholm Hansen, Georg Homuth, Marcus Ising, Eric Jorgenson, Warren W. Kretzschmar, Dean F. MacKinnon, Francis Mondimore, Niamh Mullins, Matthias Nauck, Hogni Oskarsson, Jodie N Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E Peterson, Giorgio Pistis, Saira Saeed Mirza, Robert A Schoevers, Eva C. Schulte, Grant Sinnamon, Fabian Streit, Jana Strohmaier, Matthew Traylor, Vassily Vladimirovich Trubetskoy, Daniel Umbricht, Sandra Van der Auwera, Albert M van Hemert, Shantel Marie Weinsheimer, Klaus Berger, Udo Dannlowski, J Raymond DePaulo, Katharina Domschke, Caroline Hayward, Pamela A F Madden, Ole Mors, Sara A Paciga, David J. Porteous, Catherine Schaefer, Henry Völzke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Hassan S Dashti, Wesley K Thompson
2018-05-08

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

Hae Kyung Im, Alvaro N Barbeira, Heather E Wheeler, Heather E Wheeler, Todd L. Edwards, , Eric S Torstenson, Nancy J Cox
2018-12-20

Translating GWAS findings into therapies for depression and anxiety disorders: gene-set analyses reveal enrichment of psychiatric drug classes and implications for drug repositioning

Hon-Cheong So, Kai Zhao
2017-09-29

Drug enrichment and discovery from schizophrenia genome-wide association results: an analysis and visualisation approach

Héléna Gaspar, Gerome Breen
2017-08-14

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry

Hon-Cheong So
2017-06-06

A simple mathematical approach to the analysis of polypharmacology and polyspecificity data

Gerry M. Maggiora, Vijay Gokhale
2017-03-01

The druggable genome and support for target identification and validation in drug development

Anna Gaulton, John Overington, Chris Finan, Jorgen Engmann, Anneli Karlsson, Rita Santos, Aroon Hingorani
2017-07-01

Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse
2017-02-08

Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis

Christian Gluud, Janus C Jakobsen, Katja Leth-Møller, Anne Timm
2017-05-01

Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses Reveals Enrichment Of Psychiatric Drug Classes

Hon-Cheong So
2017-08-09

Effects of Antidepressants on Sleep

Adam Wichniak, Aleksandra Wierzbicka-Wichniak
2017-08-31

Association of Hormonal Contraception with depression in the postpartum period.

Timothy A Roberts
2017-04-01

Ketamine for Depression, 1: Clinical Summary of Issues Related to Efficacy, Adverse Effects, and Mechanism of Action
2017-10-16

Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography.

Siegfried Kasper, Marie Spies, Neydher Berroterán-Infante, Georg S Kranz, Verena Pichler, Dietmar Winkler, Markus Mitterhauser, Marcus Hacker
2017-07-13

Mechanisms of action and clinical efficacy of NMDA receptor modulators in mood disorders

Mehdi Ghasemi
2017-11-08

Antipsychotic augmentation for major depressive disorder: A review of clinical practice guidelines.
2017-07

PubChem BioAssay: A Decade's Development toward Open High-Throughput Screening Data Sharing

Stephen H. Bryant, Tiejun Cheng
2016-06-14

Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia

Simone de Jong, Lewis R Vidler, David Collier, Gerome Breen
2016-11-29

Pharos: Collating protein information to shed light on the druggable genome

Søren Brunak, John Overington, Dac-Trung Nguyen, Anna Gaulton, Anne Hersey, Lars Juhl Jensen, Avi Ma'ayan, Saurabh Mehta, Andrew D Rouillard, Ajit Jadhav, Larry Sklar, Stephan C Schürer, Noel Southall, Tudor I Oprea, Cristian G. Bologa, Jayme Holmes, Subramani Mani, Oleg Ursu
2016-06-24

Antidepressants and Suicidality
2016-11-01

Association of Hormonal Contraception With Depression

Lars Vedel Kessing, Øjvind Lidegaard
2015-10-01

A global reference for human genetic variation

Adam Auton, Shane McCarthy, Richard M. Durbin, 1000 Genomes Project
2015-04-17

MAGMA: generalized gene-set analysis of GWAS data

Tom Heskes, Danielle Posthuma
2015-10-01

The Genotype-Tissue Expression (GTEx) Project
2015-11-03

DGIdb 2.0: mining clinically relevant drug-gene interactions

Alex H Wagner, Benjamin J Ainscough, Zachary L Skidmore, Katie M Campbell, Kilannin Krysiak, Obi Griffith, Elaine Mardis, Joshua F. McMichael, Adam C. Coffman
2015-05-19

DSigDB: drug signatures database for gene set analysis

Aik Choon Tan, Jaewoo Kang
2015-01-01

Vortioxetine (brintellix): a new serotonergic antidepressant
2014-01

Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals

Daphne Koller, Myrna M. Weissman, Sara Mostafavi
2014-11-26

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

Ada Hamosh
2013-02-01

Adjunctive pregabalin in partial responders with major depressive disorder and residual anxiety
2012-01

ChEMBL: a large-scale bioactivity database for drug discovery

Anna Gaulton, John Overington, Anne Hersey, Mark Davies, Louisa Bellis, Bissan Al-Lazikani, David Michalovich, Patrícia Bento

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