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Nanoscale structure of amyloid-β plaques in Alzheimer's disease

author

Jordi Pegueroles

Raúl Núñez-Llaves

Olivia Belbin

Tara L Spires-Jones

2000 -

Ellen Gelpi

Alberto Lleó

published in: Scientific Reports

date of publication: 2019-03-26

language: English

main subject: Alzheimer's disease

Cites articles 63

Date

Title

Authors

2018-11-08

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease

Shaomin Li, Lei Liu, Dennis J. Selkoe
2017-03-21

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

Bradley Hyman, Rebecca Betensky, Eloise Hudry, Shuko Takeda, Tadafumi Hashimoto, Michal Arbel-Ornath, Kishore V Kuchibhotla, Brian J Bacskai
2017-01-01

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

Huixin Xu, Dennis J. Selkoe
2017-06-21

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

Robin S B Williams, Pavlos Alifragis
2017-11-15

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer's disease patients

Ralph Michael, Rafael I. Barraquer
2017-04-17

STED imaging performance estimation by means of Fourier transform analysis

David Merino, David Artigas, Pablo Loza-Alvarez
2017-01-04

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

Robert Tycko
2017-09-18

In vivo mouse and live cell STED microscopy of neuronal actin plasticity using far-red emitting fluorescent proteins

Carola Gregor, Katrin I Willig
2017-12-01

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Olivia Belbin, Jordi Pegueroles, Christopher M Henstridge, Laia Muñoz, Raúl Núñez-Llaves, Colin Smith, Tara L Spires-Jones, Matthew Frosch, Bradley Hyman, Allyson D Roe, Abigail G Herrmann
2017-06-12

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model

Flávia C. Gomes, Isadora Matias, Helen M Melo, Gisele S Seixas da Silva, Soniza V Alves-Leon, Jorge M de Souza, Sérgio Teixeira Ferreira, Fernanda De Felice
2017-06-09

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies

Olivia Belbin
2017-03-29

Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station

Jeffrey Clark, Madeline G Rollins, William L. Klein
2016-05-30

Non-Fibrillar Oligomeric Amyloid-β within Synapses

Tara L Spires-Jones, Melissa Vaught, Bradley Hyman, Christopher M Henstridge, Robert M Koffie, Susanne Wegmann, Abigail G Herrmann, Dominic M Walsh, Roy J. Soberman
2016-04-01

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
2016-09-12

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments
2016-01-01

Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases

Eric Hayden, Tina Bilousova, Wayne W Poon, Harry V Vinters, Carol A Miller, Gregory J. Cole, Karen H Gylys, Edmond Teng
2016-02-22

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

Sathish Kumar, Oliver Wirths, Philipp Koch, Nasrollah Rezaei-Ghaleh, Dietmar R. Thal, Oliver Brüstle, Kathrin Stüber, Patrick Wunderlich, Jochen Walter
2016-07-12

A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls.

William L. Klein
2016-02-02

Amyloid β-Protein Assembly and Alzheimer's Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

Thanh D Do, Xueyun Zheng
2016-05-13

Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons

Bart De Strooper, Dries Braeken
2016-09-15

Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue

Bradley Hyman, Matthew Frosch
2015-01-22

Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis

William L. Klein
2015-08-12

Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a.
2015-07-16

Structural, morphological, and functional diversity of amyloid oligomers

Vladimir Uversky
2015-10-08

Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease

Diana L Castillo-Carranza
2015-07-03

High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification

Jeffrey Brender, Neil Marsh, Ayyalusamy Ramamoorthy
2013-07-03

Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology

Thor D Stein, Hwan-Ching Tai, Marta Marquié, Beatriz Gomez Perez-Nievas, ALBERTO SERRANO-POZO, William E. Klunk, Ronald C. Petersen, Bradley Hyman, Val J. Lowe
2013-01-01

FIB/SEM technology and Alzheimer's disease: three-dimensional analysis of human cortical synapses

Lidia Blazquez-Llorca, Angel Merchan-Perez, Jose Rodriguez, Javier DeFelipe
2013-02-01

Two-photon excitation STED microscopy in two colors in acute brain slices

Giovanni Marsicano
2013-12-01

Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies

Olivia Belbin, Jordi Clarimón
2013-06-20

Studying synapses in human brain with array tomography and electron microscopy

ALBERTO SERRANO-POZO, Tara L Spires-Jones, Thomas H. Gillingwater, Mark E. Bastin, Bradley Hyman, Matthew Frosch, Amy M Pooler, Robert M Koffie, Katherine J Kopeikina
2013-01-01

Molecular mechanisms of amyloid oligomers toxicity

Article - wd:Q64018598

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