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Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

author

Cyrille C Thinnes

Christopher T Lohans

Martine I. Abboud

T-L Yeh

Anthony Tumber

Matthew Cockman

Udo Oppermann

Christoph Loenarz

Christopher J. Schofield

1960 -

published in: Chemistry—A European Journal

date of publication: 2019-01-08

language: English

Cites articles 39

Date

Title

Authors

2018-03-09

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

Rasheduzzaman Chowdhury, Richard J. Hopkinson, Akane Kawamura, Christopher J. Schofield, Martine I. Abboud, Tom E McAllister, Ivanhoe K. H. Leung, Christian Jorgensen, Carmen Domene, Jasmin Mecinovic, Tim Claridge, Rebecca L Hancock, Kerstin Lippl
2018-06-18

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

Martine I. Abboud, Simon Davis, Wei Ge, Justin L.P. Benesch, Benedikt M. Kessler, Peter J. Ratcliffe, Julie Adam, Matthew Cockman, Roman Fischer, Rasheduzzaman Chowdhury, Mathew L Coleman, Sarah E Wilkins, Christopher J. Schofield, Maximiliano Javier Katz, Suzana Markolovic, Qinqin Zhuang, Robert K Leśniak, Weston B Struwe, Rebecca Konietzny, Pablo Wappner
2018-07-23

Collagen Prolyl 4-Hydroxylase as a Therapeutic Target.

Ronald T. Raines
2017-09-11

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.

Akane Kawamura, Peter J. Ratcliffe, Rasheduzzaman Chowdhury, Christopher J. Schofield, T-L Yeh, Martine I. Abboud, Cyrille C Thinnes, Onur Atasoylu, Christopher T Lohans, Ivanhoe K. H. Leung, Ian J Clifton, Emily Flashman, Xin Lu, Chris Pugh, Timothy D W Claridge, Anthony Tumber, James P Holt-Martyn, Kerstin Lippl
2016-01-11

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development

Christopher J. Schofield, Peter J. Ratcliffe, Mun Chiang Chan, James P Holt-Martyn
2016-04-19

Targeting Protein-Protein Interactions in the HIF System

Christopher J. Schofield, Rebecca L Hancock, Sarah E Wilkins, Martine I. Abboud
2016-08-26

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Rasheduzzaman Chowdhury, Christopher J. Schofield, Ivanhoe K. H. Leung, Martine I. Abboud, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Chris Pugh, Peter J. Ratcliffe, Timothy D W Claridge
2015-02-26

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases

Christopher J. Schofield, Wei Shen Aik, Christoph Loenarz, Cyrille C Thinnes, Michael A McDonough, Armin Thalhammer
2015-04-01

Pharmacological inhibition of FTO

Christopher J. Schofield, Wei Shen Aik, Holger B. Kramer, Cheryl Scudamore, Roger Cox
2015-06-09

Anaemia in kidney disease: harnessing hypoxia responses for therapy

Volker H. Haase
2015-07-06

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

Rasheduzzaman Chowdhury, Christopher J. Schofield, Ivanhoe K. H. Leung, Anna M Rydzik, Akane Kawamura, Chris Pugh, Peter J. Ratcliffe, Timothy D W Claridge, Anthony Tumber, Mun Chiang Chan, Marina Demetriades, James P Holt-Martyn, Tammie Bishop
2015-07-01

The promise and peril of chemical probes

Cheryl Arrowsmith, Jonathan B Baell, Paul E Brennan, Peter J. Brown, Aled Edwards, Kilian Huber, Stefan Knapp, John P. Overington, Michael A Walters, Robert N Young, Nathanael Gray, Adrian J Carter, Jayme L Dahlin, Susanne Müller, Stuart Schreiber, Leticia Toledo-Sherman, Timothy M Willson
2015-10-01

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

Kuo-Feng Hsu, Louise J. Walport, Sarah E Wilkins, Chris Pugh, Peter J. Ratcliffe, Paul E Brennan, Akane Kawamura, Christopher J. Schofield, Susanne Müller
2015-11-04

Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells

Ronald T. Raines
2014-01-30

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

Benedikt M. Kessler, Peter J. Ratcliffe, Christopher J. Schofield, Sarah E Wilkins, Luke A. Yates, Richard J. Hopkinson, Roman Fischer, Matthew Cockman, Johannes Schödel, James S. McCullagh, Robert J Gilbert, Elena Alkalaeva, Mathew L Coleman, Tianshu Feng, David C Trudgian, Martin Münzel
2014-02-18

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

Christopher J. Schofield, Rachelle S Singleton, Fabio Formenti, Roman Fischer, Julie Adam, Patrick J Pollard, Alexander Wolf, Christoph Loenarz, Emily Flashman, Mathew L Coleman, Benedikt M. Kessler, Pablo Wappner, Peter J. Ratcliffe, Matthew Cockman, Phebee Liu-Yi, Rok Sekirnik, Armin Thalhammer
2014-02-18

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

Christopher J. Schofield, Christoph Loenarz, Michael A McDonough, Matthew Cockman, Benedikt M. Kessler, Peter J. Ratcliffe, Alexander Wolf, Rok Sekirnik, Armin Thalhammer, Mukram Mohamed Mackeen
2014-02-18

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth

Christopher J. Schofield, Peter J. Ratcliffe, Christoph Loenarz, Diego Galagovsky, Matthew Cockman, Pablo Wappner, Phebee Liu-Yi, Rok Sekirnik, Armin Thalhammer, Maximiliano Javier Katz
2014-04-18

Therapeutics based on stop codon readthrough
2014-05-11

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Tobias Krojer, Rasheduzzaman Chowdhury, Christopher J. Schofield, Nigel Brissett, Nadia J Kershaw, João R C Muniz, Frank von Delft, Michael A McDonough
2014-05-21

Targeting histone lysine demethylases - progress, challenges, and the future

Christopher J. Schofield, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Akane Kawamura
2013-07-19

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

Akane Kawamura, Rasheduzzaman Chowdhury, Christopher J. Schofield, Nathan R Rose, Michael A McDonough, Peter J. Ratcliffe, Ya-Min Tian, Christopher J A Pugh, Ana Conejo-García, Kar Kheng Yeoh, Anthony Tumber, Mun Chiang Chan, Marina Demetriades
2012-10-28

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

Benedikt M. Kessler, Gail Preston, Christopher J. Schofield, Alexander Wolf, Matthew Cockman, Christoph Loenarz, Refaat B. Hamed, Rasheduzzaman Chowdhury, Carol V. Robinson, James S. McCullagh, Peter J. Ratcliffe, Mathew L Coleman, Phebee Liu-Yi, Rok Sekirnik, Armin Thalhammer, Tianshu Feng, Timothy D W Claridge, Lingzhi Gong, David C Trudgian, Mukram Mohamed Mackeen
2011-01-16

Functional specialization of ribosomes?
2011-02-18

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

Benedikt M. Kessler, Christopher J. Schofield, Mariola J. Edelmann, Holger B. Kramer, Peter J. Ratcliffe, Ya-Min Tian, Christopher J A Pugh, Kar Kheng Yeoh, Carsten Willam
2011-03-10

Inhibition of 2-oxoglutarate dependent oxygenases

Christopher J. Schofield, Nathan R Rose, Michael A McDonough, Oliver King, Akane Kawamura
2011-05

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Akane Kawamura, Rasheduzzaman Chowdhury, Christopher J. Schofield, Eleanor A L Bagg, Oliver King, Nathan R Rose, Michael A McDonough, Peter J. Ratcliffe, Ya-Min Tian, Ian J Clifton, Rob Klose, Timothy D W Claridge, Kar Kheng Yeoh, Lars Hillringhaus, Ivanhoe K. H. Leung, Esther C Y Woon
2011-04-01

Posttranslational Modifications of Ribosomal Proteins in Escherichia coli
2010-04

Prolyl 4-hydroxylase

Ronald T. Raines
2010-12

Structural studies on human 2-oxoglutarate dependent oxygenases

Rasheduzzaman Chowdhury, Christopher J. Schofield, Christoph Loenarz, Michael A McDonough, Ian J Clifton
2009-07-01

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

Rasheduzzaman Chowdhury, Christopher J. Schofield, Michael A McDonough, Jasmin Mecinovic, Christoph Loenarz, Emily Flashman, Carmen Domene, Kirsty S Hewitson
2009-09-12

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing

Mathew L Coleman, Chris Pugh

Article - wd:Q64231002

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