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Effects of interleukin-6 receptor blockade on allergen-induced airway responses in mild asthmatics.

автор

Joana A Revez

Manuel A Ferreira

John W Upham

опубликовано в: Clinical & translational immunology

дата публикации: 2019-06-14

главная тема: бронхиальная астма

Cites articles 95

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Заголовок

Авторы

2018-09-01

Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study

Scott M Damrauer, Tianxi Cai, Christopher J O'Donnell, Peter Wilson
2018-01-16

Sputum cytology during late-phase responses to inhalation challenge with different allergens.

Joana A Revez, John W Upham
2018-04-18

Eleven loci with new reproducible genetic associations with allergic disease risk.

David A Hinds, Robert Karlsson, Catarina Almqvist, Боомсма, Доррет Ирен, Lavinia Paternoster, Franz Rüschendorf, 23andMe Research Team
2017-09-07

Frontline Science: Proliferation of Ly6C(+) monocytes during urinary tract infections is regulated by IL-6 trans-signaling

Hans-Willi Mittrücker, Stefan Rose-John
2017-05-03

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Ari Waisman, Sebastian Theurich, Jens C Brüning
2017-08-08

Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway

Vinciane Saint-Criq, Jean-Michel Sallenave, Aleksander Edelman, Isabelle Sermet-Gaudelus
2017-02-17

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma

Dirk S Paul, Edwin R Chilvers, Ellie Paige, Augusto A Litonjua, John Danesh, Edwin K Silverman
2017-12-15

Lessons from ten years of genome-wide association studies of asthma.

Joana A Revez
2017-10-30

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

Hansjörg Baurecht, Kimberley Burrows, Lars G Fritsche, David L. Duffy, Stephan Weidinger, David A Hinds, Franz Rüschendorf, Edward Mountjoy, Jonas B Nielsen, Jie Zheng, Robert Karlsson, Yi Lu, Rick Jansen, Jonathan Beesley, Jenny van Dongen, Kristian Hveem, Arnulf Langhammer, Patrik K E Magnusson, Боомсма, Доррет Ирен, Konstantin Strauch, Jouke-Jan Hottenga, Lavinia Paternoster, Ronald B. Melles, Andre Franke, 23andMe Research Team, So-Young Lee
2016-10-03

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation

Christoph Garbers, Stefan Rose-John, Juliane Lokau
2016-11-28

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

Juan Hidalgo, Sylvia Heink, Christoph Garbers, Lilian Aly, Stefan Rose-John, Ari Waisman
2016-11-21

Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair

Ateequr Rehman, Stefan Rose-John
2016-08-17

Analysis of protein-coding genetic variation in 60,706 humans

Michael Boehnke, Sekar Kathiresan, Jaakko Tuomilehto, Markku Laakso, Karol Estrada, Aarno Palotie, Taru Tukiainen, Danish Saleheen, Gad Getz, Roberto Elosua, Adam Kiezun, Joanne Berghout, Pradeep Natarajan, James Ware, Hong-Hee Won, Douglas M. Ruderfer, Hugh Christian Watkins, Kaitlin E Samocha, Dongmei Yu, Eric Minikel, Christina M. Hultman, Mark Joseph Daly, Стейси Гэбриел, Steven A McCarroll, Dermot McGovern, Patrick F. Sullivan, James G. Wilson, Pamela Sklar, John Danesh, Lorena Orozco, Benjamin M. Neale, Valentin Ruano Rubio, Eric Banks, Laura D. Gauthier, Namrata Gupta, Grace Tiao, Jeremiah M Scharf, Diego Ardissino, David Altshuler, Gina M Peloso, Konrad J. Karczewski, Timothy R Fennell, Anne H O'Donnell-Luria, David N. Cooper, Daniel P Howrigan, Mark McCarthy, Shaun M Purcell, Daniel G. MacArthur, Mark DePristo, Monkol Lek, Jason Flannick, Jack A Kosmicki, Menachem Fromer, Mitja Kurki, Ami Levy Moonshine, Khalid Shakir, Christine Stevens, Ruth McPherson, Ryan Poplin
2016-05-06

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

Joachim Grötzinger, Stefan Düsterhöft, Juliane Lokau, Stefan Rose-John
2016-03-17

The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in Chinese patients with asthma.
2016-08-18

Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma

Pinja Ilmarinen
2016-08-15

Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway
2016-10-31

IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod)

Adan Jirmo, Jelena Škuljec, Gesine Hansen
2015-04-28

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

Stefan Rose-John, Antje Blumenthal, Mark J. Smyth, Geoffrey R Hill, Simon Phipps, Md Ashik Ullah, Joana A Revez, Zhixuan Loh, Manuel A Ferreira
2015-05-01

IL-6 as a keystone cytokine in health and disease

Simon Jones
2015-09-10

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

Stefan Rose-John
2015-04-12

Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma

Alba Llop-Guevara, Manel Jordana, Susanna Goncharova
2015-10-19

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

John P Kemp, Niels Grarup, Christian Gieger, Marjo-Riitta Järvelin, David M. Evans, Sven Cichon, André Uitterlinden, Regina Fölster-Holst, Medea Imboden, Eskil Kreiner-Møller, Klaus Bønnelykke, Alexessander Couto Alves, Mads Melbye, Juha Pekkanen, Ashish Kumar, Hansjörg Baurecht, Susanne Lau, Sylvain Sébert, Lavinia Paternoster, Mariona Bustamante, Sheila Barton, David A Hinds, Christel M Middeldorp, Alan D. Irvine, Stephan Weidinger, Caroline L. Relton, Craig E. Pennell, Jacob Pontoppidan Thyssen, Adnan Custovic, Keith Godfrey, John W. Holloway, Hans Bisgaard, Allan Linneberg, Markus M Nöthen, George Davey Smith, Jie Zheng, Frank Geller, Joachim Heinrich, Carol A Wang, Wenche Nystad, Bjarke Feenstra, Боомсма, Доррет Ирен, Debbie Jarvis, Liesbeth Duijts, Erik Melén, Cilla Söderhäll, Fernando Rivadeneira, Albert Hofman, Jordi Sunyer, Momoko Horikoshi, Annette Peters, Jouke-Jan Hottenga, Carole Ober, Dirkje Postma, Wendy L McArdle, Min Ae Lee-Kirsch, David P Strachan, Vincent W Jaddoe, Herman den Dekker, Hakon Hakonarson, Franz Rüschendorf, Johannes Waage, Спектор, Тимоти, Andre Franke, Michiaki Kubo, Ник Мартин, Gerard H. Koppelman, Wolf Lieb, Pirro G Hysi, Nicole Probst-Hensch, Marie Standl, Janina S Ried, Veronique Bataille, Cristina Venturini, Maria M Groen-Blokhuis, María Pino-Yanes, Scott T Weiss, Elisabeth Thiering, Albert M Levin, Supinda Bunyavanich, Rachel E Myers, Joyce Lok-Tung Wai, Carla M T Tiesler, Ronny Myhre, L Keoki Williams, Atsushi Takahashi, Bo Jacobsson, Manuel A Ferreira, Patrick M Sleiman, Guy B Marks, Melanie C Matheson, Georg Homuth, Elisabeth Mangold, Ingo Marenholz, Jorge Esparza-Gordillo, Anja Bauerfeind, Anja Matanovic, Norbert Hübner, Xue-Jun Zhang, Johan C de Jongste, Esteban Burchard, Celeste Eng
2014-08-29

Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis

Harry Karmouty-Quintana, Ernestina Melicoff, Kemly Philip, Michael R. Blackburn, Mesias Pedroza, Tingting Weng, Raquel R Bunge, Brian A. Bruckner, Matthias Loebe, Harish Seethamraju, Fayong Luo, Anuh T George
2014-05-19

T cell-intrinsic role of IL-6 signaling in primary and memory responses

Jens C Brüning, Меджитов, Руслан, Heung Kyu Lee
2014-05-03

The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels

Jouke-Jan Hottenga, Gonneke Willemsen, Jenny van Dongen, Manuel A Ferreira, Rick Jansen, Hamdi Mbarek, Боомсма, Доррет Ирен, Eco de Geus
2014-05-27

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

Christoph Garbers, Stefan Rose-John, Juliane Lokau, Mari A Nowell, Simon Jones
2014-02-20

A common 16p11.2 inversion underlies the joint susceptibility to asthma and obesity

Ivon Cuscó, Marta Puig, Андрес Метспалу, Juan R. González, Mariona Bustamante, Rachel Nadif, Lili Milani, Florence Demenais, Tõnu Esko, Manolis Kogevinas, Debbie Jarvis, Jordi Sunyer, Emmanuelle Bouzigon, Mikel Esnaola
2013-08-15

A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk

Peter M. Visscher, Joana A Revez, Joseph E. Powell, David L. Duffy, Eco de Geus, David A Hinds, Ник Мартин, Grant W. Montgomery, Manuel A Ferreira, Brenda Penninx, Боомсма, Доррет Ирен
2013-04-04

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases

Suna Onengut-Gumuscu, Antony J Cutler, Adam S. Butterworth, Deborah Smyth, Anders Malarstig, John A. Todd, John Danesh, Joanna Howson, Stephen S Rich, Daniel B Rainbow, Marcin L Pekalski, Pamela N Clarke
2013-04-05

Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling

Christoph Garbers, Joachim Grötzinger
2013-04-09

A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis

Lavinia Paternoster, Markus M Nöthen, Gonçalo Abecasis, Stephan Weidinger, Andrzej Ciechanowicz, Franz Rüschendorf, Michael Kabesch, Andre Franke

Статья - wd:Q64891223

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