Edith Sim

Edith Sim is a British researcher who is an emeritus professor at Kingston University and the University of Oxford. She was awarded the 2012 British Pharmacological Society John Vane Medal and a lifetime achievement award in 2015 from the Arylamine N-acetyltransferases Workshop Group. Source: Wikipedia (en)

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Articles 173

Date

Title

Authors

2018-06-27

Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues.

Ali J Ryan, Brigitte Crouau-Roy, Edith Sim
2017-03-22

Recent progress in N-acetyltransferase research: 7th international workshop on N-acetyltransferases (NAT): workshop report

Edith Sim, Klaus Golka
2017-06-13

Drug metabolism and antibiotic resistance in micro-organisms.

Edith Sim
2017-05-09

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach

Timothy D. McHugh, Areej Abuhammad, Alessio Ciulli, Ali J Ryan, Dimitrios Evangelopoulos, William Jacobs, Edith Sim
2016-11-18

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

Frances Platt, David G Russell, Antony Giuseppe Galione, Edith Sim, Lianne C Davis
2015-08-06

Homologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family

Anthony Elbie Glenn, Edith Sim, Eleni P Karagianni
2015-11-30

Identification of novel members of the bacterial azoreductase family in Pseudomonas aeruginosa

Ali J Ryan, Edith Sim
2014-12-01

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis

Dimitrios Evangelopoulos, Annemieke Ten Bokum, Sharon Kendall, Edith Sim
2014-10-10

Exploration of Piperidinols as Potential Antitubercular Agents,Exploration of piperidinols as potential antitubercular agents

Edith Sim
2014-06-01

Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery

Areej Abuhammad, Ali J Ryan, Edith Sim
2014

Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes

Elise Kaplan, Ali J Ryan, Jean-Christophe Nebel, Gail Preston, Edith Sim
2014

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2

Edith Sim
2014-11-29

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

Akane Kawamura, Elizabeth Morris, Edith Sim
2014-03-28

Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.

Ali J Ryan, Sam Thompson, Alan M Jones, Edith Sim
2013-02-22

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase

Areej Abuhammad, Edith Sim
2013-11-06

Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of Mycobacterium tuberculosis in macrophage.

Hung-Yuan Cheng, Ali J Ryan, Edith Sim
2013-10-02

The structure of mycobacterium marinum arylamine n-acetyltransferase

Edith Sim
2013-08-25

Structure of arylamineN-acetyltransferase fromM. tuberculosis: triumph over adversity

Edith Sim
2013-08

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity

Areej Abuhammad, Elspeth Garman, Michael A McDonough, Edith Sim
2013

A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1

Sam Thompson, Edith Sim
2012-12-28

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages

Akane Kawamura, Areej Abuhammad, Elizabeth Fullam, Elspeth Garman, Edith Sim
2012-02-14

Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker

Håkan Olsson, Ingrid Hedenfalk, Edith Sim
2012-01-01

Arylamine N-acetyltransferases--from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention

Edith Sim
2011-10-31

Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis

Dimitrios Evangelopoulos, Nicholas H. Keep, Edith Sim
2011

Activation of nitrofurazone by azoreductases: multiple activities in one enzyme

Elise Kaplan, Ali J Ryan, Edith Sim
2011-02-01

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening

Akane Kawamura, Edith Sim
2011-07-13

Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents

Edith Sim
2010-12-24

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

Areej Abuhammad, Edith Sim
2010-08-28

Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases

Ali J Ryan, Edith Sim
2010-03-01

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker

Edith Sim
2010-02-06

Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases

Edith Sim
2010-01-01

Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide

Ali J Ryan, Areej Abuhammad, Edith Sim

Human - wd:Q87441182

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