Linda A Fothergill-Gilmore

occupation: researcher

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Articles 15

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2018-05-31

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

Malcolm Walkinshaw, Meng Yuan, Iain W McNae, Paul A.M. Michels, Linda A Fothergill-Gilmore, Martin A Wear
2014-03-01

Pyruvate kinases have an intrinsic and conserved decarboxylase activity

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore, Wenhe Zhong
2014-09-24

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore, Wenhe Zhong
2013-08-17

`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore, Wenhe Zhong
2013-10-30

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

Malcolm Walkinshaw, Iain W McNae, Anton Simeonov, Linda A Fothergill-Gilmore, Douglas S Auld
2012-11-01

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore, Douglas S Auld, Martin A Wear
2011-09-09

The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site

Malcolm Walkinshaw, Iain W McNae, Linda A Fothergill-Gilmore, Douglas S Auld, Wenhe Zhong
2011-10-13

Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore
2010-02-01

Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore, Véronique Hannaert
2010-03-01

An improved strategy for the crystallization ofLeishmania mexicanapyruvate kinase

Malcolm Walkinshaw, Iain W McNae, Linda A Fothergill-Gilmore
2009-09-23

Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore
2008-12-03

The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases

Iain W McNae, Paul A.M. Michels, Malcolm Walkinshaw, Linda A Fothergill-Gilmore, José Martínez-Oyanedel, Jeffrey W Keillor
2008-03-21

Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis

Lindsay Tulloch, Nicholas J. Turner, Malcolm Walkinshaw, Iain W McNae, Linda A Fothergill-Gilmore, Véronique Hannaert
2007-03-02

The first crystal structure of phosphofructokinase from a eukaryote: Trypanosoma brucei

Malcolm Walkinshaw, Iain W McNae, Linda A Fothergill-Gilmore, José Martínez-Oyanedel, Jeffrey W Keillor
2003-06-27

Expression, purification, crystallization and preliminary crystallographic analysis of Leishmania mexicana phosphoglycerate mutase

Malcolm Walkinshaw, Iain W McNae, Linda A Fothergill-Gilmore

Human - wd:Q88633095

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