Paweł Zajdel

1974 -

country of citizenship: Poland

native language: Polish

languages spoken, written or signed: Polish

educated at: University of Montpellier

occupation: researcher, pharmaceutical chemist

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Articles 75

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Title

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2021-06-23

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties

Anna Dziubina, Agata Siwek, Xavier Bantreil, Paweł Zajdel, Magdalena Kotańska, Krzysztof Marciniec, Beata Duszyńska
2021-03-11

2-Phenyl-1 H -pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT 6 Receptor Inverse Agonists with Cognition-Enhancing Activity

Séverine Chaumont-Dubel, Maria Walczak, Xavier Bantreil, Gniewomir Latacz, Agnieszka Nikiforuk, Paweł Zajdel, Piotr Popik, Martyna Krawczyk, Rafał Kurczab
2021-10

Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide

Elżbieta Pękala, Paweł Zajdel, Karolina Słoczyńska
2021-01-13

Imidazopyridine-Based 5-HT 6 Receptor Neutral Antagonists: Impact of N 1 -Benzyl and N 1 -Phenylsulfonyl Fragments on Different Receptor Conformational States

Wojciech Pietruś, Elżbieta Pękala, Paweł Zajdel, Piotr Popik, Martyna Krawczyk, Rafał Kurczab
2021-01-01

Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

Luca Vanella, Paweł Zajdel, Rosario Pignatello
2021-09-23

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT and 5-HT Receptor Antagonist with Antipsychotic and Procognitive Properties

Ryszard Bugno, Agnieszka Nikiforuk, Paweł Zajdel, Piotr Popik
2020-04-24

Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Carine Bécamel, Katarzyna Grychowska, Paweł Zajdel, Joël Bockaert
2020-06-05

mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Paweł Zajdel, Andrzej Bojarski, Séverine Chaumont-Dubel
2020-07-24

Sustainable synthesis of a potent and selective 5-HT7 receptor antagonist using a mechanochemical approach

Paweł Zajdel, Xavier Bantreil, Frédéric Lamaty
2020-08-22

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties

Katarzyna Grychowska, Paulina Koczurkiewicz, Grzegorz Satała, Elżbieta Pękala, Rafał Kurczab, Kamil Piska, Martyna Krawczyk, Maria Walczak, Piotr Popik, Paweł Zajdel, Abdul Raheem Keeri, Andrzej Bojarski
2020-09-19

New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases

Grażyna Chłoń-Rzepa, Adam Bucki, Maciej Pawłowski, Monika Zadrożna, Krzysztof Pociecha, Elżbieta Wyska, Paweł Zajdel, Artur Świerczek
2019-11-07

Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties

Piotr Popik, Grzegorz Satała, Rafał Kurczab, Paweł Zajdel, Ryszard Bugno, Jakub Staroń, Adam Hogendorf, Tomasz Lenda, Andrzej Bojarski, Martyna Krawczyk, Jerzy Pieczykolan, Agata Hogendorf
2019-04-02

Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1H-Pyrrolo[3,2-c]quinolines with Neuroprotective and Procognitive Activity

Séverine Chaumont-Dubel, Rafał Kurczab, Wojciech Pietruś, Szymon Buda, Xavier Bantreil, Frédéric Lamaty, Elżbieta Pękala, Andrzej Bojarski, Piotr Popik, Paweł Zajdel, Katarzyna Grychowska, Paulina Koczurkiewicz, Grzegorz Satała, Kamil Piska, Martyna Krawczyk, Philippe Marin, Marcin Drop
2019-07-31

Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Paweł Zajdel
2019-06-05

2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design

Piotr Popik, Wojciech Pietruś, Grzegorz Satała, Rafał Kurczab, Paweł Zajdel, Ryszard Bugno, Adam Hogendorf, Adam Hogendorf, Tomasz Lenda, Agnieszka Nikiforuk, Justyna Kalinowska-Tłuścik, Jakub Staroń, Andrzej Bojarski, Martyna Krawczyk, Jerzy Pieczykolan
2018-01-03

Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.

Grzegorz Satała, Krzysztof Kamiński, Malgorzata Holuj, Tomasz Lenda, Marek Bednarski, Władysława Daniel, Agnieszka Nikiforuk, Irena Nalepa, Justyna Kuśmierczyk, Andrzej Bojarski, Piotr Popik, Paweł Zajdel, Piotr Chmielarz, Krzysztof Marciniec
2018-05-11

Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT1A, 5-HT7, and D2 receptor ligands

Krzysztof Marciniec, Rafał Kurczab, Grzegorz Satała, Andrzej Bojarski, Paweł Zajdel, Ewa Bębenek, Elwira Chrobak, Maria Książek, Joachim Kusz
2018-10-09

Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats

Magdalena Jastrzębska-Więsek, Lucyna Antkiewicz-Michaluk, Agnieszka Wąsik, Anna Wesołowska, Marcin Kolaczkowski, Paweł Zajdel, Jerzy Michaluk
2018-08-29

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α1A/α1D-Adrenergic Receptor Antagonist with Potential Uroselective Profile

Magdalena Kotańska, Agata Siwek, Marek Bednarski, Elżbieta Pękala, Jacek Sapa, Paulina Koczurkiewicz, Małgorzata Zygmunt, Paweł Zajdel, Joanna Knutelska, Leszek Nowiński, Aleksandra Rak-Raszewska, Vittorio Canale
2018-09-21

Amino Acid Hot Spots of Halogen Bonding: A Combined Theoretical and Experimental Case Study of the 5-HT7 Receptor

Rafał Kurczab, Andrzej Bojarski, Grzegorz Satała, Paweł Zajdel
2018-05-23

Pyrroloquinoline scaffold-based 5-HT6R ligands: Synthesis, quantum chemical and molecular dynamic studies, and influence of nitrogen atom position in the scaffold on affinity

Rafał Kurczab, Grzegorz Satała, Andrzej Bojarski, Katarzyna Grychowska, Paweł Zajdel, Jerzy Pieczykolan
2018-02-22

Biotransformation of 4-fluoro-N-(1-{2-[(propan-2-yl)phenoxy]ethyl}-8-azabicyclo[3.2.1]octan-3-yl)-benzenesulfonamide, a novel potent 5-HT7 receptor antagonist with antidepressant-like and anxiolytic properties: In vitro and in silico approach

Karolina Słoczyńska, Katarzyna Wójcik-Pszczoła, Paweł Żmudzki, Elżbieta Pękala, Paweł Zajdel
2017-12-16

Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties

Séverine Chaumont-Dubel, Grzegorz Satała, Elżbieta Pękala, Andrzej Bojarski, Piotr Popik, Paulina Koczurkiewicz, Paweł Zajdel
2017-05-04

The impact of the halogen bonding on D2 and 5-HT1A/5-HT7 receptor activity of azinesulfonamides of 4-[(2-ethyl)piperidinyl-1-yl]phenylpiperazines with antipsychotic and antidepressant properties

Rafał Kurczab, Grzegorz Satała, Magdalena Jastrzębska-Więsek, Anna Wesołowska, Andrzej Bojarski, Maciej Pawłowski, Paweł Zajdel, Krzysztof Marciniec, Anna Partyka, Vittorio Canale
2017-03-29

Novel 5-HT7R antagonists, arylsulfonamide derivatives of (aryloxy)propyl piperidines: Add-on effect to the antidepressant activity of SSRI and DRI, and pro-cognitive profile.

Rafał Kurczab, Martyna Krawczyk, Grzegorz Satała, Magdalena Jastrzębska-Więsek, Anna Wesołowska, Andrzej Bojarski, Piotr Popik, Paweł Zajdel, Anna Partyka, Vittorio Canale
2017

Continuous flow ring-closing metathesis, an environmentally-friendly route to 2,5-dihydro-1H-pyrrole-3-carboxylates

Xavier Bantreil, Frédéric Lamaty, Jean Martinez, Maciej Pawłowski, Katarzyna Grychowska, Evelina Colacino, Paweł Zajdel, Gilles Subra, Marcin Drop
2016-09

Preliminary Safety Assessment of New Azinesulfonamide Analogs of Aripiprazole using Prokaryotic Models

Karolina Słoczyńska, Elżbieta Pękala, Paweł Zajdel, Krzysztof Marciniec
2016-06-07

An Algorithm to Identify Target-Selective Ligands - A Case Study of 5-HT7/5-HT1A Receptor Selectivity

Rafał Kurczab, Andrzej Bojarski, Paweł Zajdel
2016-04-07

N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties

Grzegorz Satała, Magdalena Jastrzębska-Więsek, Anna Wesołowska, Władysława Daniel, Andrzej Bojarski, Piotr Popik, Paweł Zajdel, Krzysztof Marciniec, Anna Partyka, Vittorio Canale
2016-10-10

Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity

Séverine Chaumont-Dubel, Séverine Morisset, Paweł Zajdel
2016-04-21

Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease

Jean Martinez, Anna Partyka, Xavier Bantreil, Grzegorz Satała, Anna Wesołowska, Frédéric Lamaty, Piotr Popik, Andrzej Bojarski, Maciej Pawłowski, Katarzyna Grychowska, Evelina Colacino, Paweł Zajdel, Philippe Marin, Gilles Subra
2016-09-10

Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity

Paweł Żmudzki, Magdalena Kotańska, Marek Bednarski, Jacek Sapa, Małgorzata Zygmunt, Paweł Zajdel, Krzysztof Marciniec, Agata Siwek, Joanna Knutelska, Leszek Nowiński, Aleksandra Rak-Raszewska, Vittorio Canale

Human - wd:Q92525389

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