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Pharmacological chaperones stabilize retromer to limit APP processing

author

Gregory Petsko

1948 -

Dagmar Ringe

1942 -

published in: Nature Chemical Biology

date of publication: 2014-04-20

main subject: molecular chaperones

Cites articles 36

Date

Title

Authors

2014-02-01

Retromer: a master conductor of endosome sorting

Christopher G Burd, Peter J Cullen
2013-02-01

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

Brian D McCabe, Karen S. Marder, Lorraine Clark
2012-10-15

The retromer complex - endosomal protein recycling and beyond
2012-07-11

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Kári Stefánsson, Augustine Kong, Hreinn Stefansson, Unnur Þorsteinsdóttir, Aarno Palotie, Patrick Sulem, Tushar Bhangale, Gyda Bjornsdottir, Daníel F. Guðbjartsson, Erik G Jönsson, Ole A. Andreassen, Stacy Steinberg, Jon Snaedal, Johanna Huttenlocher, Thorlakur Jonsson
2012-06-05

Identification of Alzheimer disease-associated variants in genes that regulate retromer function

Peter Henry St George-Hyslop, Lindsay A. Farrer
2012-04-06

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport
2012-01-01

Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing

Olav M. Andersen, Camilla Gustafsen, Peder Madsen, Thomas E Willnow
2011-12-22

Sorting nexins provide diversity for retromer-dependent trafficking events
2011

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins

Eugene Valkov, Rajesh Ghai, Sandeep Chhabra, Brett M. Collins
2011-01

Assembly and solution structure of the core retromer protein complex

Brett M. Collins, Rohan D. Teasdale
2010-10-11

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

Sandra I. Vieira, Sandra Rebelo, Jens Wiltfang
2010-09-01

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex

Rudolph E. Tanzi
2009-12-28

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition

Paul Mathews, Stephen D Ginsberg
2009-10-13

What are pharmacological chaperones and why are they interesting?

Gregory Petsko, Dagmar Ringe
2009-02-19

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Marc Tessier-Lavigne
2008-05-20

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

Karen Duff, Ottavio Arancio, Barry Ganetzky
2008-03

Structure of Vps26B and mapping of its interaction with the retromer protein complex

Brett M. Collins, Rohan D. Teasdale
2007-10-25

Functional architecture of the retromer cargo-recognition complex
2007-02

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Ekaterina Rogaeva, Peter Henry St George-Hyslop, Gerold Schmitt-Ulms, Olav M. Andersen, Rivka Inzelberg, Thomas E Willnow, Clinton Baldwin, Joseph H. Lee, Kathryn L. Lunetta, Sandro Sorbi, Lindsay A. Farrer, Dennis W. Dickson, Robert C. Green, Richard Mayeux, Toshitaka Kawarai, Ronald C. Petersen, L. Adrienne Cupples, Neill R Graff-Radford, Amalia Bruni, Innocenzo Rainero, Lorenzo Pinessi, Yosuke Wakutani, Christopher Bohm, Taiichi Katayama, Nobuto Shibata, Ranjan Duara, Fanggeng Zou, Robert P Friedland, You-Qiang Song, Steven G. Younkin
2007-02

Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

Gregory Petsko, Dagmar Ringe, Raquel L Lieberman
2007-02-17

Identification of hot spots within druggable binding regions by computational solvent mapping of proteins.
2006-10-01

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis
2006-09-01

LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease

Thomas J Montine
2006-05-28

The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain

Juan S. Bonifacino
2006-11-02

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

Paul S. Aisen
2005-12-01

Model-guided microarray implicates the retromer complex in Alzheimer's disease
2005-09-07

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Tilman Breiderhoff, Olav M. Andersen, Michael Gotthardt, Thomas E Willnow, Anders Nykjaer, Roberto Cappai, Colin L. Masters, Bradley Hyman
2005-06-19

Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

Brett M. Collins
2005-02

Recycle your receptors with retromer
2005-02-08

Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites.
2004-08

The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor
2004-04

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

Cecilia Arighi, Juan S. Bonifacino

Article - wd:Q33824953

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