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Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

published in: Proceedings of the National Academy of Sciences of the United States of America

date of publication: 2015-07-27

language: English

Cites articles 54

Date

Title

Authors

2014-09-15

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

Andreas Heger, Chris Ponting, Iain C Macaulay
2014-09-11

Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus

Chan-Wang Joaquim Lio, Andrew L Kau, Chyi-Song Hsieh
2014-04-21

Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance

Bridget Conley, Imran S Khan, Maureen A Su
2014-02-10

Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer

Tiebang Kang, B Mark Evers
2014-01-16

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

Matthieu Giraud, Nir Hacohen, David E Root
2014-08-27

AIRE acetylation and deacetylation: effect on protein stability and transactivation activity

Federica Incani, Luisella Saba, Maria Cristina Rosatelli, Irene Messana
2013-10-14

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

Francis Collins, Narisu Narisu, Brian L Black, Axel Visel, NISC Comparative Sequencing Program, Len A. Pennacchio
2013-10-10

Super-enhancers in the control of cell identity and disease

Denes Hnisz, Brian J. Abraham, Richard A. Young
2013-06-06

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

Matthew D Galbraith, Robin Dowell, William C Hahn, Joaquín M Espinosa
2013-04-01

Selective inhibition of tumor oncogenes by disruption of super-enhancers

Christopher R. Vakoc, Richard A. Young
2013-04-11

Master transcription factors and mediator establish super-enhancers at key cell identity genes
2013-03-01

Aire-dependent thymic development of tumor-associated regulatory T cells

James P. Allison
2013-01-14

Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance
2013-03-07

Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting
2013

Two faces of brd4: mitotic bookmark and transcriptional lynchpin
2013-05-01

SnapShot: Transcription regulation: pausing.
2012-10-01

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

Karen Adelman
2012-05-30

Autoimmune regulator is acetylated by transcription coactivator CBP/p300.

Jaak Vilo, Pärt Peterson, Ana Rebane, Mario Saare
2012-08-17

Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition
2012-05-02

Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection

Alessandro Sette, Marc K. Jenkins, John Sidney
2012-02-24

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)

Olivier Mirguet
2012-03-04

Fast gapped-read alignment with Bowtie 2

Steven Salzberg, Ben Langmead
2012-02-06

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes

Kalle Saksela
2012-01-23

Place your BETs: the therapeutic potential of bromodomains
2011-12-27

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

Matthieu Giraud, Richard A. Young, Jakub Abramson
2011-09-13

Bromodomains as therapeutic targets

Stefan Knapp
2010-12-23

Selective inhibition of BET bromodomains

Panagis Filippakopoulos, Sarah Picaud, Yuchuan Wang, Oleg Fedorov, Andrew L. Kung, Stefan Knapp, Tyler T Hickman, Olaf Wiest, Ildiko Felletar, Carl Philpott, Tom D Heightman
2010-04-30

c-Myc regulates transcriptional pause release

Ryan Flynn, Richard A. Young
2010-03-05

Distinct factors control histone variant H3.3 localization at specific genomic regions

Kyung-Min Noh, Aaron D Goldberg, Peter W. Lewis, Ariane Chapgier, Richard J Gibbons, Douglas Higgs, Philip D Gregory, John Greally, Deyou Zheng, Peter J Scambler, Charles David Allis, Fyodor Urnov, Shahin Rafii, Laura A Banaszynski, Duancheng Wen, Simon J Elsaesser, Xingyi Guo
2010-01-08

Aire's partners in the molecular control of immunological tolerance

Matthieu Giraud, Jakub Abramson
2009-10-13

Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution

Wulf Blankenfeldt, Matthias Geyer
2009-10-01

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

Saadi Khochbin, Jeroen Krijgsveld, Karin Sadoul, Darren J Hart, Sophie Rousseaux, Christoph W Müller

Article - wd:Q35961245

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