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Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545.

author

Gianluigi Zaza

Valentina Masola

1982 -

Maurizio Onisto

published in: Oncotarget

date of publication: 2017-05-01

language: English

main subject: acute kidney injury

Cites articles 63

Date

Title

Authors

2017-02-06

Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease

Ton J Rabelink, Gangqi Wang, Johan Van Der Vlag
2016-10-06

Heparanase: From basic research to therapeutic applications in cancer and inflammation
2016-11-14

Heparanase is required for activation and function of macrophages

Ami Aronheim
2016-07-28

Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury

Valentina Masola, Gianluigi Zaza, Maurizio Onisto, Gisella Vischini
2016-04-08

Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases
2016-03-29

Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx

Ton J Rabelink, Pierre-Louis Tharaux
2016-02-09

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

Ton J Rabelink, Johan Van Der Vlag
2015-11-09

Recent data concerning heparanase: focus on fibrosis, inflammation and cancer

Valentina Masola, Gianluigi Zaza, Maurizio Onisto
2015-06-04

Impact of heparanase on renal fibrosis

Valentina Masola, Gianluigi Zaza, Maurizio Onisto
2015-03-01

Endothelin and tubulointerstitial renal disease

Berthold Hocher
2014-09-23

Signaling mechanisms of the epithelial-mesenchymal transition
2014-09-18

Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition
2014-07-09

Role of heparanase-driven inflammatory cascade in pathogenesis of diabetic nephropathy

Johan Van Der Vlag
2014-06-15

Heparanase is a key player in renal fibrosis by regulating TGF-β expression and activity

Valentina Masola, Gianluigi Zaza, Maurizio Onisto
2013-11-11

Heparanase mediates renal dysfunction during early sepsis in mice

Eric P Schmidt
2013-08-02

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues
2013-03-13

Versatile role of heparanase in inflammation
2013-06-24

Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation
2013-10-01

The road from AKI to CKD: the role of endothelin
2012

PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model
2012-11-15

Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression

Gabriel Nussbaum
2012-09-13

Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function

Mona Boaz
2012-01-11

Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation

Marcel Spaargaren, Rogier M. Reijmers
2011-11-21

Heparanase is essential for the development of diabetic nephropathy in mice

Johan Van Der Vlag
2011-11-01

Cellular pathophysiology of ischemic acute kidney injury
2011-08-03

Significance of heparanase in cancer and inflammation
2011-02-22

Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels
2011-02-01

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

Maree Smith
2011-01-20

Acute kidney injury: lessons from experimental models
2011-12-20

Urinary heparanase activity in patients with Type 1 and Type 2 diabetes

Johan Van Der Vlag
2010-01-05

The role of heparanase in diseases of the glomeruli

Marian Klinger
2010-01-01

Experimental ischemia-reperfusion: biases and myths-the proximal vs. distal hypoxic tubular injury debate revisited.

Article - wd:Q41855773

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