Douglas M Fowler

opleiding gevolgd aan: Scripps Research Institute, Northwestern-universiteit

beroep: onderzoeker

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Artikels 18

Date

Titel

Auteurs

2023-07-03

An Atlas of Variant Effects to understand the genome at nucleotide resolution

Douglas M Fowler, Alan F Rubin
2021-12-08

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

Willow Coyote-Maestas, A Suma, Kenneth A Matreyek, Douglas M Fowler, Vincenzo Carnevale, Chad L Myers, Daniel Schmidt
2020-01-01

An improved platform for functional assessment of large protein libraries in mammalian cells

Kenneth A Matreyek, Douglas M Fowler
2020-05-04

A premalignant cell-based model for functionalization and classification of PTEN variants

Jesse T Chao, Warren M Meyers, Fabian Meili, Kenneth A Matreyek, Douglas M Fowler, Christopher J R Loewen
2020-05-11

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

Melissa A Chiasson, Frederick P Roth, Debora Marks, Douglas M Fowler, Marta Verby
2020-06-01

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

John C Rose, Nicholas A Popp, Christopher D Richardson, Cindy T Wei, Jacob E Corn, Dustin J Maly, Douglas M Fowler
2020-06-01

High-throughput, microscope-based sorting to dissect cellular heterogeneity

Heather Z Huang, Douglas M Fowler, Cole Trapnell
2020-06-08

Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

Douglas M Fowler, Nobuhiko Tokuriki
2020-09-01

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

Melissa A Chiasson, Debora Marks, Douglas M Fowler, Marta Verby
2019-02-21

An open-source platform to distribute and interpret data from multiplexed assays of variant effect

Lea M Starita, Alan F Rubin, Douglas M Fowler, Jochen Weile, Frederick P Roth, Jay Shendure, Anthony T Papenfuss
2019-11-05

Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning

Vanessa E. Gray, Douglas M Fowler
2019-05-30

Applying Multiplex Assays to Understand Variation in Pharmacogenes

Melissa A Chiasson, Maitreya J Dunham, Douglas M Fowler
2019-07-01

Mutagenesis-based protein structure determination

Melissa A Chiasson, Douglas M Fowler
2018-05-21

Multiplex assessment of protein variant abundance by massively parallel sequencing

Kenneth A Matreyek, Beth Martin, Melissa A Chiasson, Vanessa E. Gray, Martin Kircher, Ronald J Hause, William E Evans, Douglas M Fowler, Jay Shendure
2017-07-27

Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions

Vanessa E. Gray, Ronald J Hause, Douglas M Fowler
2017-07-24

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics

John C Rose, Dustin J Maly, Douglas M Fowler
2017-09-22

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase

Barbara Taskinen, Douglas M Fowler
2016-09-25

Enrich2: a statistical framework for analyzing deep mutational scanning data

Alan F Rubin, Anthony T Papenfuss, Terry Speed, Douglas M Fowler

Human - wd:Q64633514

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