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Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

author

Benedetta Mannini

Francesco Simone Ruggeri

Roberta Cascella

1983 -

Michele Perni

Alessandra Bigi

Janet R Kumita

Nunilo Cremades

1979 -

Cristina Cecchi

Tuomas Knowles

Michele Vendruscolo

1966 -

Chris Dobson

1949 - 2019

published in: Communications Biology

date of publication: 2020-08-13

Cites articles 64

Date

Title

Authors

2020-04-13

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

Thomas C. T. Michaels, Anđela Šarić, Georg Meisl, Michele Vendruscolo, Sara Snogerup Linse, Tuomas Knowles, Chris Dobson, Alexander J Dear, Katja Bernfur, Samo Curk
2020-06-25

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

Benedetta Mannini, Rodrigo Cataldi, Janet R Kumita, Francesco Simone Ruggeri, Francesco Antonio Aprile, Michele Vendruscolo
2020-04-01

Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation

Ryo C. Yanagita, Kazuhiro Irie
2020-01-03

A Focused Chiral Mutant Library of the Amyloid β 42 Central Electrostatic Cluster as a Tool To Stabilize Aggregation Intermediates

Alejandro R Foley, Jevgenij A Raskatov
2019-01-15

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Ryan Limbocker, Francesco Simone Ruggeri, Michele Perni, Georg Meisl, Benedetta Mannini, Thomas C. T. Michaels, Minkoo Ahn, Janet R Kumita, Sara Snogerup Linse, Fabrizio Chiti, Michele Vendruscolo, Chia-Hsiung Cheng, Johnny Habchi
2019-02-27

Chirality Dependence of Amyloid β Cellular Uptake and a New Mechanistic Perspective

Ariel J Kuhn, Jevgenij A Raskatov
2019-08-01

Trapping and Characterization of Nontoxic Aβ42 Aggregation Intermediates

Alejandro R Foley, Marco Rolandi, Jevgenij A Raskatov
2018-07-29

Calcium signaling in Alzheimer's disease & therapies

King-Ho Cheung
2018-09-26

SAR by kinetics for drug discovery in protein misfolding diseases

Thomas C. T. Michaels, Sara Snogerup Linse, Tuomas Knowles, Michele Vendruscolo, Chris Dobson, Johnny Habchi, Chia-Hsiung Cheng
2018-06-28

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Michele Perni, Patrick Flagmeier, Ryan Limbocker, Francesco Antonio Aprile, Celine Galvagnion, Gabriella Heller, Georg Meisl, Janet R Kumita, Pavan Kumar Challa, Julius B. Kirkegaard, Benedetta Mannini, Cristina Cecchi, Nunilo Cremades, Tuomas Knowles, Fabrizio Chiti, Michele Vendruscolo, Chris Dobson, Serene W Chen, Roberta Cascella, Ellen A A Nollen
2018-08-10

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

Benedetta Mannini, Francesco Simone Ruggeri, Michele Perni, Tuomas Knowles, Michele Vendruscolo
2017-05-12

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

Chris Dobson
2017-12-01

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.

Roberta Cascella, Liming Ying, Giuliana Fusco, Serene W Chen, Philip Williamson, Michele Perni, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Chris Dobson, Alfonso De Simone
2017-06-21

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

Sara Snogerup Linse, Chris Dobson, Michele Vendruscolo, Pietro Sormanni, Francesco Antonio Aprile
2017-01-17

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Celine Galvagnion, Georg Meisl, Julius B. Kirkegaard, Patrick Flagmeier, Serene W Chen, Ryan Limbocker, Pietro Sormanni, Gabriella Heller, Francesco Antonio Aprile, Cristina Cecchi, Tuomas Knowles, Michele Vendruscolo, Nunilo Cremades, Chris Dobson, Roberta Cascella, Ellen A A Nollen
2017-03-03

The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues.

Thomas A. Rando
2017-07-19

Suppression of Oligomer Formation and Formation of Non-Toxic Fibrils upon Addition of Mirror-Image Aβ42 to the Natural l-Enantiomer

Xiaolin Zhang, Jevgenij A Raskatov
2016-06-01

The amyloid hypothesis of Alzheimer's disease at 25 years

John Anthony Hardy, Dennis J. Selkoe
2016-02-12

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease

Chris Dobson, Michele Vendruscolo, Priyanki Joshi, Ana R Costa, Maho Yagi-Utsumi, Sara Snogerup Linse
2016-12-23

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

Ryan Limbocker, Benedetta Mannini, Oskar Hansson, Sara Snogerup Linse, Tuomas Knowles, Michele Vendruscolo, Janet R Kumita, Chris Dobson, Johnny Habchi, Chia-Hsiung Cheng
2016-01-19

Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations

Chris Dobson, Roberta Cascella, Cristina Cecchi, Heath Ecroyd, Mark R. Wilson, Joel N Buxbaum
2016-09-13

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

Matteo Becatti, Cristina Cecchi
2016-07-25

Amyloid-β(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity

Erich Wanker
2016-06-08

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

Chris Dobson, Michele Vendruscolo
2016-06-28

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

Chris Dobson, Michele Vendruscolo, Patrick Flagmeier, Celine Galvagnion, Alexander K Buell, Emma Sparr
2016-06-30

Introduction of d-Glutamate at a Critical Residue of Aβ42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity

Jevgenij A Raskatov
2015-02-16

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

Jenny Presto, Chris Dobson, Michele Vendruscolo, Christopher J Dunning, Henrik Biverstal, Jan Johansson, Sara Snogerup Linse, Firoz Roshan Kurudenkandy, André Fisahn, Birgitta Frohm
2015-07-09

Anxious moments for the protein tyrosine phosphatase PTP1B.
2015-04-08

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

David Klenerman, Serene W Chen, Francesco Antonio Aprile, Cintia Roodveldt, Nicholas W. Wood, Tuomas Knowles, Carlos Alfonso, German Rivas, Andrey Y Abramov, José María Valpuesta, Nunilo Cremades, Chris Dobson, Erwin J De Genst
2015-02-07

Interactions between misfolded protein oligomers and membranes: A central topic in neurodegenerative diseases?

Daniel Otzen, Maria Andreasen
2015-05-14

Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions

Concetta Di Natale, Roberta Cascella, Cristina Cecchi, Marilisa Leone, Adele Di Matteo
2015-01-14

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.

Francesco Simone Ruggeri, Hilal Lashuel

Article - wd:Q98463556

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