Michel Chrétien

1936 -

Michel Chrétien (born March 26, 1936) is a Canadian medical researcher specializing in neuroendocrinology research at the Institut de recherches cliniques de Montréal, or Clinical Research Institute of Montreal, (IRCM). He is a younger brother of former Canadian prime minister, Jean Chrétien. Source: Wikipedia (en)

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Articles 325

Date

Title

Authors

2021-02-01

Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface-expression of LDLR and CD36 and NLRP3 inflammasome

Simon Bissonnette, Michel Chrétien, Jennifer L Estall, May Faraj
2020-02-03

The enigma of soluble LDLR: could inflammation be the key?

Majambu Mbikay, Michel Chrétien, Janice Mayne
2020-09-16

Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children

Majambu Mbikay, Issa Diarra, Michel Chrétien, Olesya Fedoryak
2020-10-11

White Adipose Tissue Surface Expression of LDLR and CD36 is Associated with Risk Factors for Type 2 Diabetes in Adults with Obesity

Simon Bissonnette, Hubert Vidal, Michel Chrétien, May Faraj
2020-11-19

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

Wadih Arap, Michel Chrétien, Nabil Seidah
2018-09-01

Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function

Michel Chrétien, Daniel Figeys
2018-04-23

Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas

Majambu Mbikay, Michel Chrétien, Olesya Fedoryak, Janice Mayne, Francine Sirois, Angela Raymond
2018-02-15

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children.

Mahamadou A. Thera, Ogobara K. Doumbo, Christopher V Plowe, Drissa Coulibaly, Kirsten E Lyke, Issa Diarra, Michel Chrétien
2018-01-15

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.

Nabil Seidah, Michel Chrétien, Majambu Mbikay
2017-09-01

The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response

Monica Taljaard, Michel Chrétien
2017-12-01

Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection

Xiangguo Qiu, Michel Chrétien
2016-05

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)

Michel Chrétien
2016-06-13

Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection

Jonathan Audet, Xiangguo Qiu, Michel Chrétien
2016-12-10

Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol

Michel Chrétien
2015-07-02

The apoB-to-PCSK9 ratio: A new index for metabolic risk in humans

Michel Chrétien
2015-05-18

β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells

Michel Chrétien, Daniel Figeys
2015-04-07

Relationship between testosterone, estradiol and circulating PCSK9: Cross-sectional and interventional studies in humans

Monica Taljaard, Claire Gavin, Michel Chrétien, Majambu Mbikay
2014-09-02

Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

Michel Chrétien
2014-03-01

PCSK9: a key modulator of cardiovascular health

Nabil Seidah, Michel Chrétien
2014-03-27

Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6

Michel Chrétien
2013-06-17

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions

Nabil Seidah, Michel Chrétien, Majambu Mbikay
2013-05-10

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

Jean Davignon, Michel Chrétien
2013-07-08

Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions

Michel Chrétien
2013-10-23

How the prohormone theory solved two important controversies in hormonal and neural Peptide biosynthesis

Michel Chrétien
2012-11-08

My road to Damascus: how I converted to the prohormone theory and the proprotein convertases

Michel Chrétien
2012-08-08

Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation

Nabil Seidah, Michel Chrétien
2012-02-04

Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample

Majambu Mbikay, Michel Chrétien, Francine Sirois, Nadine Kaefer, Kabwe Nkongolo
2011-09-24

Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity

Majambu Mbikay, Michel Chrétien, Ajoy Basak, Francine Sirois, Kabwe Nkongolo
2011-10-01

Mechanisms required to ensure research integrity

Michel Chrétien
2011-08-03

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

Nabil Seidah, Majambu Mbikay, Jean Davignon, Michel Chrétien, Janice Mayne, Thilina Dewpura, Angela Raymond, Teik Chye Ooi
2011-01-01

The prohormone theory and the proprotein convertases: it is all about serendipity

Michel Chrétien
2011-03-10

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells

Annik Prat, Nabil Seidah, Michel Chrétien

Human - wd:Q3309276

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